Instant adhesive tissue patch and preparation method thereof

Abstract

The invention relates to an instant adhesive tissue patch and a preparation method thereof, and belongs to the technical field of medical materials. The instant adhesive tissue patch comprises a meshsubstrate, the mesh substrate is coated with a fibrinogen complex layer and a prothrombin layer, and the fibrinogen complex layer and the prothrombin layer are frozen at an ultralow temperature. The instant adhesive tissue patch can be rapidly attached to tissue without suture lines or drawing pins, so that nerve injury caused by fixation can be avoided and operation time is greatly saved; the patch is directly placed at an operation defect part in use, and thrombin and fibrinogen are crosslinked in a body fluid wet environment to quickly form fibrin glue for fixing the patch to the tissue; and the effects of rapid hemostasis and wound healing can be achieved at the same time.

Description

technical field [0001] The invention relates to the technical field of medical materials, more specifically, the invention relates to an instant adhesive tissue patch and a preparation method thereof. Background technique [0002] Tension-free repair using a mesh mesh is widely accepted in soft tissue defect repair. During the tissue healing process after the mesh mesh is implanted, the extracellular matrix produced by the granulation tissue penetrates and grows into the mesh structure of the mesh, thereby strengthening the tissue at the surgical site and serving the purpose of hernia repair. [0003] In the prior art, the commonly used clinical hernia repair patch is usually made of polypropylene material, which has many advantages such as low density, corrosion resistance, and moderate inflammatory stimulation, but also has disadvantages: if it cannot be used with The viscera are in direct contact with each other, which is easy to adhere and erode the abdominal wall organ...

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Problems solved by technology

[0003] In the prior art, the commonly used clinical hernia repair patch is usually made of polypropylene material, which has many advantages such as low density, corrosion resistance, and moderate inflammatory stimulation, but also has disadvantages: if it cannot be used with Viscera are in direct contact, easy to adhere, and erode the abdominal wall organs; the material is not soft enough, which may cause a greater inflammatory reaction, etc.

The commonly used method of mesh mesh fixation is to fix the mesh to the tissue with absorbable or non-absorbable surgical sutures or "puck pins", but either way may cause tissue or Patients with postoperative chronic pain due to nerve damage

[0004] In addition, it has been reported in the literature that folding and displacement of the mesh mesh due to poor fixation after implantation, resulting in hard and sharp edges, caused patients with a strong sense of foreign body and discomfort after surgery, and even intestinal fistula, Severe complications such as bladder fistula

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