Method for synthesizing 2-amino-5-nitrothiazole

Abstract

The invention discloses a method for synthesizing 2-amino-5-nitrothiazole, which comprises the following steps: (1) in an inert atmosphere, adding diethylamine, acetyl chloride and triethyl orthoacetate into a reaction container, uniformly mixing, stirring to react for 12-24 hours, and distilling and purifying the reaction product to obtain N, N-dimethylformamide dimethyl acetal, (2) in an inert atmosphere, mixing N, N-dimethylformamide dimethyl acetal with nitromethane, heating the mixture to 80-100 DEG C for reflux reaction, carrying out reduced pressure distillation on the reaction productto remove the solvent, and purifying to obtain N, N-dimethyl nitroethylene, and (3) in an inert atmosphere, putting N, N-dimethyl nitroethylene into a reaction container, sequentially adding ethanol,liquid bromine and thiourea, reacting at room temperature, after the reaction is finished, filtering a reactant, washing with ice ethanol, drying to obtain a white solid, adding water, and filtering to obtain the 2-amino-5-nitrothiazole. According to the method for synthesizing 2-amino-5-nitrothiazole, the raw materials are easy to obtain, the cost is low, and the yield can reach 60%.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a method for synthesizing 2-amino-5-nitrothiazole. Background technique [0002] 2-Amino-5-nitrothiazole is an important synthetic intermediate, which is widely used in the fields of dye and pharmaceutical synthesis. At present, in the synthesis process of 2-amino-5-nitrothiazole, the intermediate 2-aminothiazole is usually first synthesized from raw materials, and then the target product is obtained by nitration. Among them, the starting materials for the synthesis of 2-aminothiazole mainly include chloroacetaldehyde, chloral, vinyl acetate or vinyl ether. Nitrification steps can be roughly divided into two categories, one is the mixed acid direct nitration method; the other is the nitramine rearrangement method. But above-mentioned method yield is all not high, and used raw material is not easy to obtain, and raw material cost is higher. Contents of the invention ...

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Problems solved by technology

[0003] The technical problem to be solved in the present invention is to provide a new method for synthesizing 2-amino-5-nitrothiazole, so as to solve the problem that the raw materials for synthesizing 2-amino-5-nitrothiazole in the prior art are not easy to obtain, the cost is high, and the yield is high. low problem

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