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Ozone nanobubble mouthwash and preparation method

A nano-bubble and mouthwash technology, which is applied in the field of mouthwash, can solve the problems of no permeability, limited oral disease effect, inability to kill periodontal disease pathogenic bacteria, etc., and achieve strong sterilization and strong cleaning effects

Active Publication Date: 2020-07-31
深圳市陆讯纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] In addition, the above two types of mouthwashes for treatment and health care and ozone mouthwashes are not permeable and cannot penetrate into the oral tissue. They can only kill the pathogenic bacteria on the surface of the oral tissue, but cannot kill the pathogenic bacteria in the oral tissue. Can not kill the pathogenic bacteria of periodontal disease in the dental plaque, that is, the pathogenic bacteria of periodontal disease in the biofilm on the tooth surface, so the above-mentioned mouthwash has limited effect on the prevention and treatment of oral diseases

Method used

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  • Ozone nanobubble mouthwash and preparation method

Examples

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preparation example Construction

[0073] The preparation method of the ozone nano-bubble mouthwash, the bubble retaining agent is added into water to dissolve, and the ozone microbubbles below 60 μm are generated in the obtained aqueous solution; under the action of the bubble retaining agent, the ozone microbubbles shrink to form in the aqueous solution Ozone nano-bubbles do not exist in this aqueous solution.

[0074] It is also possible to add the surfactant and water-soluble polymer to the seawater, concentrated seawater, underground salt water, salt lake water, and salt well water to dissolve, and generate ozone microbubbles below 60 μm in the resulting aqueous solution, and the ozone microbubbles in this aqueous solution In, shrink to form ozone nano bubbles and stay in this aqueous solution.

[0075] Ozone Nanobubble Mouthwash is diluted 1 to 10 times with water before use.

[0076] The present invention preferably uses sea salt above food grade, polyvinylpyrrolidone and alkyl polyglucoside as the air bu...

Embodiment 1

[0080] use the machine

[0081] Pressurized dissolved air micro-bubble generator (manufactured by Jiangsu Yixing Duoyuan Environmental Protection Technology Co., Ltd.), the flow rate of the aqueous solution is 2m 3 / h.

[0082] Ozone gas generator (manufactured by Yifeng Hongyuan Environmental Protection Technology Co., Ltd., Chengdu, Sichuan, model HY-YW-060), the amount of ozone gas generated is 60g / h. Use medical oxygen as the gas source for the ozone gas generator.

[0083] aqueous solution

[0084] Put sea salt, alkyl polyglucoside, and polyvinylpyrrolidone into water respectively as shown in Table 1 and stir to dissolve, the conductivity of the aqueous solution after dissolving is 122.5ms / cm, and the pH is adjusted to 5.0 (using Taiwan AZ Instrument Corp. IP67 multifunctional waterproof handheld pH / conductivity / salinity / dissolved oxygen measuring instrument).

[0085] Table 1 Aqueous solution composition

[0086] Aqueous solution composition Usage amount ...

Embodiment 2～8

[0101] The manufacturing methods of Examples 2-8 are the same as those of Example 1, except that the materials added in the aqueous solution are different, and the percentages are different. See Table 2 for details.

[0102] Table 2 is the additive material and percentage content thereof for the manufacture of ozone nanobubble mouthwash of Examples 1-8, as well as the manufacturing time and the nanobubble measurement data when it is made.

[0103] Table 2

[0104]

[0105] Table 3 is the ozone concentration when the ozone nano-bubble mouthwash of embodiment 1~8 is made and the ozone concentration of each storage time period, and all data are to use intelligent portable ozone detector (manufactured by Jiangsu Hangzhou Qiwei Instrument Co., Ltd., model Y-615) measured data.

[0106] Table 3 Ozone concentration unit: mg / L Storage conditions: sealed in a glass bottle, stored at room temperature and protected from light

[0107]

[0108]

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Abstract

The invention provides a preparation method for ozone nanobubble mouthwash capable of maintaining ozone concentration for a long time at room temperature. By using a microbubble generator, ozone nanobubbles are made in an aqueous solution in which a bubble retention agent is dissolved; the ozone nanobubbles of which the number exceeds 129x108 / 100mL and the particle sizes are less than 500nm are generated, and the bubbles can stay in the aqueous solution stably for a long time. The ozone concentration of the ozone nanobubble mouthwash is within a range of 18.5-43mg / L, and after the ozone nanobubble mouthwash is hermetically stored in a dark place for three months at room temperature, the ozone concentration of the ozone nanobubble mouthwash can still maintain 60% or more of the ozone concentration when the ozone nanobubble mouthwash is prepared. The ozone nanobubble mouthwash can be applied to the field of preventing and treating oral diseases, eliminating ozostomia, whitening teeth andthe like.

Description

technical field [0001] The invention relates to an ozone nano-bubble mouthwash and a preparation method thereof, belonging to the technical field of mouthwash. Background technique [0002] Periodontal disease is a chronic inflammatory disease caused by periodontal pathogens. The incidence rate of periodontal disease is particularly high among middle-aged and elderly people, and the prevalence rate of periodontal disease among those aged 55-64 is as high as 82.5%. Periodontal disease is also the leading cause of tooth loss after the age of 40. In recent years, there have been many periodontal diseases and systemic diseases (circulatory disease, diabetes, aspiration pneumonia, arteriosclerosis, osteoporosis, chronic arthritis, aspiration pneumonia, non-alcoholic fatty liver, intestinal flora imbalance, etc.) According to related reports, people have recognized the importance of preventing and treating periodontal disease and maintaining oral health. [0003] Mouthwash is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/96A61K8/81A61K8/60A61K8/22A61K8/20A61P1/02A61P11/02A61P31/02A61Q11/00
CPCA61K8/965A61K8/22A61K8/20A61K8/604A61K8/8129A61K8/8176A61Q11/00A61P1/02A61P11/02A61P31/02
Inventor 钱新玲陆荣生区大锴
Owner 深圳市陆讯纳米科技有限公司
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