Method for catalytically preparing chromene pyrimido indazolone derivative serving as drug intermediate

Abstract

The invention belongs to the field of organic synthesis, and discloses a method for catalytically preparing a drug intermediate chromene pyrimido indazolone derivative, which comprises the following steps: adding an ethanol water solution into a reaction container, adding aromatic aldehyde, 1H-indazole-3-amine and 4-hydroxycoumarin, stirring at room temperature, uniformly mixing, and finally adding an acidic ionic liquid catalyst; heating until the solvent flows back, keeping the temperature until the raw material point disappears, and stopping stirring after the reaction is finished; coolingthe reaction solution to room temperature, grinding the precipitated solid, performing standing, and carrying out suction filtration to obtain filter residues; washing the filter residue with ethanol,and carrying out vacuum drying to obtain a product; and adding reaction raw materials into the filtrate after suction filtration to carry out the next round of reaction. According to the method, thenew acidic ionic liquid catalyst is utilized, and the ethanol aqueous solution is used as a reaction solvent, so that the catalytic reaction efficiency can be effectively improved, the adding amount of the catalyst is reduced, the ethanol aqueous solution can effectively play a role of a recrystallization solvent, and the purification process is simplified.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a method for preparing pharmaceutical intermediate chromenopyrimidindazolone derivatives by catalyzing an acidic ionic liquid. Background technique [0002] Indazolone and its derivatives are nitrogen-containing heterocyclic compounds, which exist in various natural compounds or pharmaceutical compounds, and are a class of compounds with important pharmacological activities, such as anti-cancer, anti-inflammatory, anti-HIV and anti- Obesity and other activities have been widely used in the research and preparation of anti-tumor drugs. Compounds containing pyrimidine ring structures also have extensive research value in the fields of anti-AIDS, diabetes, thrombosis, and sterilization. In addition, compounds containing chromene structures have a wide range of biological activities and photochromic effects, and can be applied in the field of molecular recognition. Ther...

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Problems solved by technology

[0006] Aiming at the shortcomings of the large amount of catalyst used and the complicated purification process in the process of preparing the drug intermediate chromenopyrimidindazolone derivatives by catalytic means in the prior art, the present invention uses a new acidic ionic liquid catalyst to prepare the drug intermediate At the same time, using the ethanol aqueous solution as the reaction solvent can not only effectively improve the catalytic reaction efficiency, reduce the dosage of the catalyst, but also make the ethanol aqueous solution effectively play the role of the recrystallization solvent, simplify the purification process, and greatly save the reaction time. cost

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