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Degradable medical material and preparation method thereof

A raw material, silicone rubber technology, applied in the field of degradable medical materials and their preparation, can solve the problems of cracking and brittleness, and achieve the effect of expanding the application field, reducing the shrinkage rate, and having excellent rigidity and toughness.

Active Publication Date: 2020-08-04
HEFEI GENIUS NEW MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high crystallinity of PHA materials, they are prone to brittleness and cracking in actual use, which limits the application of PHA materials in the pharmaceutical industry

Method used

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  • Degradable medical material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 85 parts of poly-β-hydroxybutyric acid, 10 parts of silicone rubber, and 0.5 parts of heat stabilizer into the vacuum mixer, mix evenly for 1 minute, then add 5 parts of surface-modified chitin whiskers to it, and continue mixing 1min, and finally add 0.2 parts of silicone rubber vulcanizing agent to it and knead for 5min, then the tablet can be opened, or the degradable medical material can be obtained by granulating through die drawing. The processing temperature of the internal mixer is 200° C., the pressure of the upper ram is 0.65 MPa, and the screw speed of the internal mixer is 30 r / min.

Embodiment 2

[0030] Add 77 parts of β-hydroxybutyric acid and β-hydroxyvaleric acid copolymer, 15 parts of silicone rubber, and 0.5 parts of heat stabilizer into the vacuum mixer, mix well for 2 minutes, and then add surface-modified chitin whiskers 8 parts, continue to knead for 2 minutes, and finally add 0.3 parts of silicone rubber vulcanizing agent to it and knead for 7 minutes to open the tablet, or granulate through the die to obtain the degradable medical material. The processing temperature of the internal mixer is 195° C., the pressure of the upper ram is 0.65 MPa, and the screw speed of the internal mixer is 40 r / min.

Embodiment 3

[0032] Add 70 parts of polyhydroxybutyrate, 20 parts of silicone rubber, and 0.5 parts of heat stabilizer into the vacuum mixer, mix uniformly for 3 minutes, then add 10 parts of surface-modified chitin whiskers, and continue mixing for 3 minutes. Finally, 0.4 parts of silicone rubber vulcanizing agent is added to it and kneaded for 10 minutes, and then the tablet can be opened, or the degradable medical material can be obtained by granulating through die drawing. The processing temperature of the internal mixer is 190° C., the pressure of the upper ram is 0.65 MPa, and the screw speed of the internal mixer is 50 r / min.

[0033] The performance of the degradable medical material prepared by the above-mentioned examples 1-3 is shown in Table 1 below:

[0034] Table 1

[0035] Test item / unit standard test Example 1 Example 2 Example 3 Density / g / cm 3

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Abstract

The invention discloses a degradable medical material and a preparation method thereof. The degradable medical material is prepared from the following raw materials in parts by mass: a PHA material, silicone rubber, surface modified chitin whiskers, a silicone rubber vulcanizing agent and a heat stabilizer through step-by-step mixing. According to the invention, the degradable PHA material is usedas a base material, the silicone rubber with good biocompatibility is uniformly mixed into the base material by a dynamic vulcanization technology to be used as a toughening agent, and the degradablesurface treatment chitin whiskers are used as a filling reinforcing agent, so that the degradable composite material with excellent rigidity and toughness is obtained.

Description

technical field [0001] The invention relates to the field of general plastics, in particular to a degradable medical material and a preparation method thereof. Background technique [0002] Biomedical materials are materials used to diagnose, treat, repair or replace damaged tissues and organs or enhance their functions. It is the basis for the study of artificial organs and medical devices, and has become an important branch of contemporary materials science. Especially with the vigorous development and major breakthroughs of biotechnology, biomedical materials have become a hot spot for scientists from all over the world to research and develop. Biomedical materials are divided into inert biomedical materials, active biomedical materials, and biodegradable and absorbable biomedical materials according to the biochemical reaction level of the materials in the physiological environment. Medical polymer materials are the earliest, most widely used and most used materials in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L83/07C08L5/08C08K5/14
CPCC08L67/04C08L2205/03C08L2205/16C08L2201/06C08L83/04C08L5/08C08K5/14
Inventor 杨桂生赵鑫朱敏
Owner HEFEI GENIUS NEW MATERIALS
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