Medicine for treating and preventing diabetic nephropathy

A technology for diabetic nephropathy and a drug, applied in the field of diabetic nephropathy, can solve the problems such as the undiscovered combination of tagagliflozin and DPP24 inhibitor in the treatment of diabetic nephropathy, and achieve the effect of improving compliance, good curative effect and improving cloxoprotein

Active Publication Date: 2020-08-07
GUANGZHOU LIXIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, no patent literature has been found on the combination of tepagliflozin and DPP24 inhibitors in the treatment of diabetic nephropathy

Method used

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  • Medicine for treating and preventing diabetic nephropathy
  • Medicine for treating and preventing diabetic nephropathy
  • Medicine for treating and preventing diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, compound medicine tablet of the present invention

[0025] Recipe: (1000 tablets)

[0026] Tegliflozin 10g

[0027] Vildagliptin 10g

[0028] Microcrystalline Cellulose 16.2g

[0029] β-cyclodextrin 19.4g

[0030] L-fucose 24.4g

[0031] 5% povidone 95% ethanol solution appropriate amount

[0032] Magnesium Stearate 1.0%

[0033] Preparation method: take the prescribed amount of tepagliflozin and vildagliptin and mix them uniformly according to the method of equal increase, set aside, weigh the prescribed amount of microcrystalline cellulose, β-cyclodextrin and L-fucose, and mix with the raw materials The drug is fully mixed, passed through a 80-mesh sieve, and an appropriate amount of 5% povidone 95% ethanol solution is added to make a soft material, granulated with a 25-mesh sieve, dried at 50°C for 6 hours, and granulated with a 25-mesh granule, and the water content of the granules is controlled to be 2- 3%, the dried granules are mixed evenly w...

Embodiment 2

[0034] Embodiment 2, compound medicine tablet of the present invention

[0035] Recipe: (1000 tablets)

[0036] Tegliflozin 50g

[0037] Saxagliptin 20g

[0038] Microcrystalline Cellulose 85.4g

[0039] β-cyclodextrin 110.9g

[0040] L-fucose 153.7g

[0041] 5% povidone 95% ethanol solution appropriate amount

[0042] Magnesium Stearate 1.0%

[0043] The preparation method was the same as in Example 1, and each tablet of the prepared compound drug contained 50 mg of tipagliflozin and 20 mg of saxagliptin.

Embodiment 3

[0044] Embodiment 3, compound medicine tablet of the present invention

[0045] Recipe: (1000 tablets)

[0046] Tegliflozin 75g

[0047] Vildagliptin 30g

[0048] Microcrystalline Cellulose 133.3g

[0049] β-cyclodextrin 200g

[0050] L-fucose 266.7g

[0051] 5% povidone 95% ethanol solution appropriate amount

[0052] Magnesium Stearate 1.0%

[0053] The preparation method was the same as in Example 1, and each tablet of the prepared compound drug contained 75 mg of tipagliflozin and 30 mg of vildagliptin.

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PUM

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Abstract

The invention relates to the technical field of diabetic nephropathy, in particular to a medicine for treating and preventing diabetic nephropathy, which comprises 10 to 100 mg of tianagliflozin and 10 to 50 mg of DPP24 inhibitor. The medicine prepared by the invention can remarkably reduce the content or expression quantity of blood urea nitrogen, blood creatinine, 24h urine protein, urine protein quantification and transforming growth factor-beta1, remarkably improves the expression quantity of the klotho protein, has a better effect of treating and preventing diabetic nephropathy, can be stored for a long time, and has small toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of diabetic nephropathy, in particular to a medicine for treating and preventing diabetic nephropathy. Background technique [0002] Diabetes and its chronic complications have seriously affected human health and quality of life. In recent years, the number of people with diabetes has been on the rise. The incidence of diabetes in all age groups in the world was about 2.8% in 2000 and is expected to be 4.4% by 2030. Diabetic nephropathy is one of the most important comorbidities in diabetic patients. The incidence rate in my country is also on the rise, and it has become the second cause of end-stage renal disease, second only to various glomerulonephritis. Due to its complex metabolic disorders, once it develops into end-stage renal disease, it is often more difficult to treat than other kidney diseases. Therefore, timely prevention and treatment is of great significance for delaying diabetic nephropathy. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/351A61K45/06A61P13/12A61P3/10A61K9/48A61K9/20
CPCA61K9/2054A61K9/4866A61K31/351A61K45/06A61P3/10A61P13/12
Inventor 高悦译赵桂龙陈成斌蒋莉娟刘恩桂王灿顶韩锋赖文燕黄夏梦
Owner GUANGZHOU LIXIN PHARM CO LTD
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