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Application of human pyrroline-5-carboxylate reductase in preparation of drugs for treating skin wounds

A skin wound and reductase technology, which is applied in the direction of oxidoreductase, skin diseases, drug combination, etc., can solve the problem of skin wound healing that has not yet been healed, and achieve the goal of lightening the degree of inflammation and infiltration of wound margin tissue, promoting healing, and accelerating the healing rate Effect

Pending Publication Date: 2020-08-14
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the direct use of P5CR in skin wound healing

Method used

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  • Application of human pyrroline-5-carboxylate reductase in preparation of drugs for treating skin wounds
  • Application of human pyrroline-5-carboxylate reductase in preparation of drugs for treating skin wounds
  • Application of human pyrroline-5-carboxylate reductase in preparation of drugs for treating skin wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0039] (1) Treatment of skin wounds with P5CR, normal saline, and bFGF

[0040] (1) One group of rats was topically applied P5CR (100 μL / time) on one side of the wound, and locally applied normal saline (100 μL / time) on the other side of the wound.

[0041] (2) Another group of rats was treated with topical bFGF (100 μL / time) on one side of the wound and bFGF (100 μL / time) on the other side of the wound, and the wounds were randomly selected for administration.

[0042] (3) Rats in the two groups were externally applied medicine once a day after trauma, for a total of 14 days.

[0043] (3) Observe the growth of epidermal granulation tissue on the wound surface and the growth and healing of epithelial tissue every day, and take pictures and record the construction of rat wound models and skin wound healing in the P5CR treatment group and normal saline treatment group and the P5CR treatment group The wound model construction and skin wound healing of the rats treated with bFGF ...

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Abstract

The invention discloses an application of human pyrroline-5-carboxylate reductase in preparation of drugs for treating skin wounds. A rat skin wound model is established, and treatment is performed byadopting the human pyrroline-5-carboxylate reductase (P5CR) to confirm that the healing rate of rats in a P5CR treatment group is accelerated and the inflammatory infiltration degree of wound edge tissues is relatively light. The expression peak of the transforming growth factor-[beta]1 (TGF-beta1) appears earlier, which indicates that the P5CR plays a role in the skin tissue wound healing and repairing processes of the rats, so that the human P5CR can be used for preparing the drugs for treating the skin wounds.

Description

technical field [0001] The invention relates to the application of a medicine, in particular to the application of human pyrroline-5-carboxylate reductase as a medicine for treating skin wounds. Background technique [0002] Wound healing is a conservative evolutionary process between species, which includes spatial and temporal staggering, and consists of three overlapping stages: inflammation, proliferation, and remodeling [SeifertAW, 2012; 7(4):e32875 , RichardsonR, 2013 Jun; 133(6):1655-65]. The inflammatory phase is characterized by platelet aggregation, coagulation, and leukocyte migration; the proliferative phase is characterized by re-epithelialization, angiogenesis, fibroplasia, and wound contraction; and finally, the remodeling phase occurs within a month of injury during which time is accompanied by Production of collagen and matrix proteins, the dermis responds to injury and then reverts to its pre-injury phenotype [Kirsner RS, 1993 Oct; 11(4):629-40]. [0003]...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61P17/02A01K67/02
CPCA61K38/44A61P17/02A01K67/02C12Y105/01002A01K2227/105A01K2267/03
Inventor 孟照辉胡伟叶雨佳万雯李瑞
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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