Application of deferoxamine mesylate for injection in treating senile bone loss and bone marrow stem cell aging
A technology of deferoxamine mesylate and bone marrow stem cells, which is applied in the field of medicine, can solve the problems of the decrease in the number and activity of autologous BMSC cells, achieve the effect of low toxicity and ensure safety
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[0036] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
[0037] 1. The therapeutic effect of deferoxamine mesylate (DFO) for injection on osteoporosis in aged rats was clarified
[0038] Using a 12-month-old rat model, the therapeutic effects of different doses of deferoxamine mesylate for injection (trade name: Desferin) on osteoporosis in aged rats were investigated. Experimental groups: 12-month-old high-dose group (60 mg / kg, n=7), low-dose group (20 mg / kg, n=6), normal saline group (n=6), 2-month-old normal control group (n= 6). The intraperitoneal in...
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