White tea extract as well as preparation method, administration method and application thereof in resisting depression

A white tea extract, white tea technology, applied in application, drug combination, drug delivery and other directions, can solve the problems of large toxic and side effects, fast enzyme inhibition, etc., and achieve the effects of repairing olfactory damage, improving damage, and improving sucrose preference.

Inactive Publication Date: 2020-08-21
EAST CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] ①Monoamine oxidase inhibitors: rapid enzyme inhibitory effect, rapid recovery of enzyme activity after drug withdrawal, relatively large toxic and side effects
[0031] However, there are no reports about white tea extracts improving the behavioral symptoms of depression and repairing the accompanying olfactory impairment.

Method used

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  • White tea extract as well as preparation method, administration method and application thereof in resisting depression
  • White tea extract as well as preparation method, administration method and application thereof in resisting depression
  • White tea extract as well as preparation method, administration method and application thereof in resisting depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The preparation of embodiment 1 white tea extract

[0079] 10g of raw white tea (manufacturer: Fujian Qinghua Tea Co., Ltd.; product name: Chuancheng old tree white tea; quality grade: special grade; net content: 210g) was ground and pulverized with a mortar, according to the ratio of 1:50 (w / w) Leaf / extraction medium ratio, mixed with 500g distilled water, using a rotary evaporator, steamed under vacuum at 85°C for 10min, quickly filtered to get the supernatant, and then transferred to a constant temperature water bath to cool down to 30°C to obtain white tea extract, which can be placed in -20°C refrigerator for storage.

Embodiment 2

[0080] The model construction of embodiment 2 chronic unpredictable stress (CUMS) mice

[0081] Fifty 6-week-old male C57BL / 6J mice, weighing 20-40g, were randomly divided into five groups, 10 in each group: control group (WT), chronic stress group (CU), fluoxetine group (CF), high concentration white tea group (HT) and low concentration white tea group (LT). Except the control group, the other groups received CUMS treatment. The Chronic Unpredictable Mild Stress Protocol (CUMS) consists of a variety of mild stressors: (1) 24-hour food deprivation treatment; (2) 24-hour water deprivation treatment; (3) 24-hour 45° cage tilt treatment; (4) treatment with light / dark cycle inversion; (5) treatment with dirty mouse cage for 24 hours; (6) treatment with forced swimming at 4°C for 5 minutes; (7) treatment with tail pinching for 1 minute. To make stressors and types unpredictable, stressors were arranged in a random fashion, with the potential to occur at any time during the three-...

Embodiment 3

[0082] Embodiment 3 carries out drug treatment to CUMS model mice

[0083] After the three-week CUMS mice were modeled, the high-concentration white tea group and the low-concentration white tea group were given white tea extract at a dose of 40 mg / kg and 20 mg / kg for one week by nasal feeding respectively, while fluoxetine Fluoxetine group was intraperitoneally injected with 20 mg / kg of fluoxetine for one week, while the chronic stress group was not administered. During nasal feeding, the mice were controlled in the hand, and administered in a supine position. Take the dropper and drop the drug solution to the front of the nostril of the mouse, let it inhale the drug solution freely, if there is a part that has not been inhaled, then add the same amount dropwise to keep the same dose for each mouse.

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Abstract

The invention belongs to the technical field of Chinese herbal medicine component extraction, and discloses a method for preparing a white tea water extract by taking white tea as a raw material. According to the invention, a nasal feeding method is also used for feeding the white tea extract to a subject, depressive symptoms, including pleasant sensation loss behaviors and easy despiring behaviors, can be effectively relieved; the white tea extract can also be used for repairing olfactory impairment or deficiency symptoms accompanied by depression. The invention provides a new thought for development of drugs / health care products / foods for treating depression and accompanied olfaction deficiency.

Description

technical field [0001] The invention belongs to the technical fields of extraction and separation of medicinal components and the application of food and medicine, and relates to an extract of active ingredients of white tea and a preparation method thereof, and the effect of white tea water extract on effectively alleviating depression and repairing the damage of the sense of smell accompanied by depression in the application. Background technique [0002] White tea is a rare tea with a long history. In the past, most white tea was exported, but it has gradually entered the domestic public's field of vision in recent years. With the development of science and technology, the research on the health benefits of white tea at home and abroad has become more in-depth. The crossover and penetration of knowledge in various fields has made breakthroughs in the research on white tea, and followed a strict experimental research model. [0003] The processing technology of white tea ...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61P25/24A23L33/105
CPCA23V2002/00A61K9/0043A61K36/82A61K2236/15A61K2236/331A23L33/105A61P25/24A23V2250/214A23V2200/322
Inventor 高良才周天胡文浩谢归香林泽杰渠荟超
Owner EAST CHINA NORMAL UNIVERSITY
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