Parameter monitoring device and system for proton therapy

Abstract

The invention provides a parameter monitoring device and system for proton therapy. The device comprises a recurrent neural network module, a PET acquisition module, a prediction module, a judgment module and an adjustment module, wherein the recurrent neural network module provides a trained recurrent neural network model, and the trained recurrent neural network model provides a nonlinear relationship between positron nuclide activity distribution and dose distribution of a proton beam; the PET acquisition module acquires a PET image of the positron nuclide activity distribution generated bya reaction between protons and tissues from a positron annihilation tomography system; the prediction module inputs the PET image into the trained recurrent neural network model, and the dose distribution and Bragg peak position of the proton beam are predicted through the nonlinear relationship between the positron nuclide activity distribution and the dose distribution; the judgment module judges a position relationship between the predicted dose distribution and Bragg peak position of the proton beam and a target area; and the adjustment module judges whether beam outlet parameters of theproton beam need to be adjusted or not according to a judgment result of the judgment module. By the device and the system provided by the invention, parameter monitoring and adjustment for proton therapy are realized.

Description

Technical field [0001] The invention relates to the field of nuclear medicine imaging, in particular to a parameter monitoring device and system for proton therapy. Background technique [0002] The current methods of treating tumors (cancer) mainly include surgery, chemotherapy and radiotherapy, and more than 70% of tumor patients need to receive radiotherapy alone or combined with radiotherapy. The ideal radiation therapy is to give a lethal dose to tumor cells while minimizing the radiation dose of surrounding normal organs and tissues. Proton therapy is such a cutting-edge radiotherapy technology for precise treatment of cancer. The radiation dose curve of the proton beam in tissues (such as humans, animals, etc.) first slowly rises, and then gradually becomes faster, until the maximum dose deposition occurs at the Bragg peak, and then rapidly decreases and approaches zero. The unique dose-depth characteristics of the proton beam enable the tumor tissue to receive the maximu...

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For example, the prompt gamma method lacks a high-performance detector suitable for this gamma-ray energy spectrum region, and the dete...

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