81 results about "Proton beam radiation" patented technology

A system for an intensity-modulated proton therapy of a predetermined target volume within an object includes a proton source to generate a proton beam, a number of proton beam forming units and a beam nozzle having an outlet for the proton beam to penetrate the predetermined target volume of the object, thereby defining a cross sectional scanning exit area. The system includes further a beam bending magnet disposed upstream of the nozzle, and an x-ray tube and an x-ray imager. The x-ray tube is associated with an irradiation channel within the beam bending magnet, wherein the irradiation channel is oriented along the prolongation of the nominal proton beam direction thereby delivering the x-ray beam along the proton beam direction.

The invention comprises an X-ray system that is orientated to provide X-ray images of a patient in the same orientation as viewed by a proton therapy beam, is synchronized with patient respiration, is operable on a patient positioned for proton therapy, and does not interfere with a proton beam treatment path. Preferably, the synchronized system is used in conjunction with a negative ion beam source, synchrotron, and / or targeting method apparatus to provide an X-ray timed with patient respiration and performed immediately prior to and / or concurrently with particle beam therapy irradiation to ensure targeted and controlled delivery of energy relative to a patient position resulting in efficient, precise, and / or accurate noninvasive, in-vivo treatment of a solid cancerous tumor with minimization of damage to surrounding healthy tissue in a patient using the proton beam position verification system.

A system for treating a patient by proton therapy, also called gantry, includes a proton beam guide involving, in particular, magnets, quadropoles, and the like and having an outlet aperture for guiding and directing the proton beam to the side in the patient that is to be treated. In addition, a patient table that cab en displaced in a controllable manner is provided for moving the patient into a desired position relative to the proton beam. The inventive proton beam guide and control device is mounted down from the patient table in the direction of the beam guide in a supported manner whereby being able to rotate or pivot about a horizontal axis.

A process for an intensity-modulated proton therapy of a predetermined volume within an object includes discretising the predetermined volume into a number of iso-energy layers each corresponding to a determined energy of the proton beam. A final target dose distribution is determined for each iso-energy layer. The final target dose distribution or at least a predetermined part of this final target dose distribution is applied by parallel beam scanning by controlling the respective beam sweepers, thereby scanning one iso-energy layer after the other using an intensity-modulated proton beam while scanning a predetermined iso-energy layer.

System and method of dynamically presenting visual representations of a target volume in an anatomical context to an operator-user of a charged particle radiation therapy system. The visual representations are integrated as a part of a treatment console graphical user interface (GUI) and presented as a part of a holistic view of treatment information. The visual representations are digitally reconstructed radiographs (DRRs) constructed based on anatomical images captured before the therapy session, or alternatively during a treatment session using an imaging system attached to the radiation treatment system. In an online mode, the on-screen visual representations are rendered in synchronization with the irradiation delivery process.

Systems and methods for radiation treatment planning in proton therapy using pencil beam scanning (“PBS”) are described. More particularly, the systems and methods described in the present disclosure related to quantifying the output from a proton therapy system implementing PBS. The systems and methods described in the present disclosure can therefore be implemented when commissioning a new proton therapy system, or when performing quality assurance (“QA”) on a proton therapy system. A spot delivery pattern that includes a spiral out pattern is used for beam delivery. A number of control points along the spot delivery pattern define a beam pause time during which delivery of the proton beam is paused. Radiation measurements are obtained at the control points and at the end of the spot delivery pattern, and these radiation measurements are used to compute field size factors for field sized associated with the segments of the spot delivery pattern.

Systems and methods for radiation treatment planning in proton therapy using pencil beam scanning (“PBS”) are described. More particularly, the systems and methods described in the present disclosure related to quantifying the output from a proton therapy system implementing PBS. The systems and methods described in the present disclosure can therefore be implemented when commissioning a new proton therapy system, or when performing quality assurance (“QA”) on a proton therapy system. A spot delivery pattern that includes a spiral out pattern is used for beam delivery. A number of control points along the spot delivery pattern define a beam pause time during which delivery of the proton beam is paused. Radiation measurements are obtained at the control points and at the end of the spot delivery pattern, and these radiation measurements are used to compute field size factors for field sized associated with the segments of the spot delivery pattern.

A method includes generating a nominal dose distribution based on an image and clinical goals. The method further includes generating a setup error dose distribution based on range and setup uncertainties. The method further includes generating a dose distribution for a parameter of an internal organ. The method further includes optimizing a planned dose distribution of an intensity modulated proton therapy plan by minimizing a total objective value including the nominal dose distribution, the setup error dose distribution dose distribution, and the dose distribution for the internal organ. The method further includes generating a final dose distribution for the intensity modulated proton therapy plan based on beam parameters of the optimized planned dose distribution. The method further includes controlling a proton therapy apparatus configured to deliver proton therapy based on the intensity modulated proton therapy plan with the optimized planned dose distribution.

The invention relates a displacement-located double-stationary-chamber double-beam proton therapy system. Based on a cyclotron, two rotary rack therapy rooms and two double-stationary-beam-therapy chambers are provided, wherein one double-fixed-beam therapy chamber is combination of a horizontal beam and a vertical beam, and the other double-fixed-beam therapy chamber is combination of a horizontal beam and a 45-degree inclined beam. Due to the double-fixed-beam combination, the number of rotary racks can be reduced, and the construction cost can be greatly reduced; and due to the structure of double fixed beams, varieties of tumors which can be treated by the fixed beams can be greatly expanded. According to the displacement-located double-stationary-chamber double-beam proton therapy layout scheme for proton therapy, the equipment occupied space can be reduced, the construction cost for proton treatment devices can be greatly reduced, and the treatment effect can be ensured.

The invention discloses a safe interlocking protection system of a proton therapy accelerator. Safety-type PLC is adopted as a data processing and executing component, the protection system is connected with a water cooling system, a vacuum system, a superconducting magnet system, an ion source system and an RF system, wherein the water cooling system is used for using flowing cooling water to take away heat generated by the operation of the accelerator, the vacuum system is used for providing a vacuum environment for the operation of the accelerator, the superconducting magnet system is usedfor providing a stable magnetic field environment for the operation of the accelerator, the ion source system is used for guiding proton beams from hydrogen molecule ionization, the RF system is usedfor providing an accelerating electric field for particles and maintaining the electric field stability in the accelerator through feedback control, fault and state signals of the sub system of the accelerator are collected by a safe interlocking system of the accelerator, and an interlocking signal of the sub systems of the accelerator is distributed by the safe interlocking system of the accelerator. By means of the system, the sub systems of the accelerator can be controlled to ensure the safety of the adjacent sub systems, and the damage to equipment is reduced to the maximum extent.

The invention discloses a proton beam flow intensity modulation method and system. In a proton therapy device based on a cyclotron, an energy selection module makes the transmission efficiency of the proton beam with different energies very different, but a treatment end requires the proton beam to maintain a stable flow intensity range. The method of the invention firstly obtains the beam loss and the transmission efficiency of the proton beam with different energies in an energy reduction process after the energy modulation of the proton beam, and obtains a flow intensity ratio from low energy to high energy. According to the clinical requirements of the proton beam flow intensity dynamic ratio, after different energy points which have been subjected to energy modulation undergo expansion and collimation, the flow intensity modulation within a design proportional region is completed and the flow ratio can be controlled within a certain value. The method and the system of the invention are based on the Monte Carlo calculation method and the beam optics. The design method is reliable, and the realization scheme has a small space requirement, which is important for maintaining the beam stability in the proton therapy process.

The invention comprises a method and apparatus for reducing a kinetic energy of positively charged particles, comprising the steps of: (1) transporting the positively charged particles from an accelerator into an exit nozzle system along a beam line; (2) providing a first chamber of the exit nozzle system, the first chamber comprising: an incident side comprising an incident aperture, an exit side comprising an exit aperture, and a beam path of the positively charged particles from the incident aperture to the exit aperture; (3) filling the beam path in the chamber with a liquid; and (4) using the liquid to reduce the kinetic energy of the positively charged particles. The kinetic energy dissipater is optionally used in combination with a proton therapy cancer treatment system and / or a proton tomography imaging system.

The present invention relates to an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide. An embolization particle of the invention for use in the treatment of cancer in combination with X-ray radiation or proton beam radiation, or use in embolization, is also described. The invention also relates to a process for producing an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide, which process comprises: (i) providing a microparticle; (ii) contacting the microparticle with a plurality of the nanoparticles; and (iii) heating the microparticle and the nanoparticles to form the embolization particle.

The invention discloses an emergency stop control method for a proton therapy patient positioning device. The method includes obtaining alarm information of a dangerous area in a patient positioning process, confirming whether a person enters the dangerous area of the treatment room according to the obtained alarm information of the dangerous area in the positioning process of the patient, the control unit determines whether or not a person enters the dangerous area based on the acquired information, when it is confirmed that a person has entered the dangerous area of the treatment room, controlling the patient positioning device to stop running, when it is determined that a person has entered a hazardous area, the control unit abruptly stopping the patient positioning device in the treatment room, when a signal is detected that may pose a threat to the safety of personnel, the operation of the positioning device can timely stopped, on the one hand, can avoid the injury of the personnel caused by the mechanical collision, on the other hand, can avoid the harm that the personnel are in the radiation area and irradiated by the radiation in the working process of the image system. Theinvention can improve the safety protection effect in the treatment room and avoid the safety accident in the treatment room.

The invention provides a parameter monitoring device and system for proton therapy. The device comprises a recurrent neural network module, a PET acquisition module, a prediction module, a judgment module and an adjustment module, wherein the recurrent neural network module provides a trained recurrent neural network model, and the trained recurrent neural network model provides a nonlinear relationship between positron nuclide activity distribution and dose distribution of a proton beam; the PET acquisition module acquires a PET image of the positron nuclide activity distribution generated bya reaction between protons and tissues from a positron annihilation tomography system; the prediction module inputs the PET image into the trained recurrent neural network model, and the dose distribution and Bragg peak position of the proton beam are predicted through the nonlinear relationship between the positron nuclide activity distribution and the dose distribution; the judgment module judges a position relationship between the predicted dose distribution and Bragg peak position of the proton beam and a target area; and the adjustment module judges whether beam outlet parameters of theproton beam need to be adjusted or not according to a judgment result of the judgment module. By the device and the system provided by the invention, parameter monitoring and adjustment for proton therapy are realized.

The invention comprises a method and apparatus for treating a tumor of a patient, in a beam treatment center comprising a floor, with positively charged particles, comprising: (1) a synchrotron mounted to an elevated floor section above the floor of the beam treatment center; (2) a beam transport system, comprising: at least three fixed-position beam transport lines, where none of the synchrotron and the beam transport system penetrate through the floor of the beam treatment center; (3) the positively charged particles transported from the synchrotron, through the beam transport system, to a position above a patient positioning system during use; and (4) an optional repositionable nozzle system connected to a first, second, and third fixed-position beam transport line at a first, second, and third time, respectively, where the nozzle track forms an arc of a circle and the repositionable nozzle system moves along the nozzle track.

The invention discloses an accelerator safety interlock system for proton therapy. The accelerator safety interlock system for proton therapy comprises an upper computer PC, a switch, a PLC, a photoelectric conversion module and each subsystem of the accelerator; the upper computer PC is used for remotely monitoring and operating the state and operation of the accelerator subsystems, setting permissions and switching different modes at the same time, so as to facilitate the launching and debugging of the accelerator; the photoelectric conversion module converts an optical fiber signal into anelectrical signal that can be used by the PLC; each subsystem of the accelerator comprises a water cooling system, a lifting system, a superconducting magnet system, a vacuum system, an ion source system, an RF system and a lead-out zone system. The invention has the beneficial effects that: the hardware use and differentiation of the accelerator safety interlock system is very detailed, and is convenient to use; the system accelerator safety interlock system responds faster; and the accelerator safety interlock system is easier to use and operate, and has higher working precision.

The invention relates to a treatment room switching and beam energy-changing automation system for proton therapy devices. The system includes: an accelerator control module; a mirror accelerator generation module connected to an accelerator device; and a treatment room switching module connected to the accelerator control module; and a condition monitoring module coupled to the accelerator control module, the image accelerator generation module, and the treatment room switching module. The system establishes a complete copy of the real accelerator device through a mirror accelerator technology to provide access to the treatment room, meets the need for the treatment room to detect the state of the accelerator, while avoiding the risk that the treatment room can incorrectly access the realaccelerator device. at the same time, on the basis of arbitrating and ordering the access requests of different treatment rooms by the treatment room switching module, the accelerator is operated infull dynamic circulation according to the treatment needs to generate beam output of different energies, and the final treatment needs can be satisfied.

A system and methods are provided for generating intensity modulated proton therapy plans robust to various kinds of delivery uncertainties with the capability for treatment planners to control the balance between plan quality and robustness. The system obtains a representation of a subject and a proton beam configuration that describes a number of beamlets and their respective arrangement. The system computes an objective function, in the treatment planning system, first part of which is about dose deviations from the prescribed dose in the target volumes, second part of which is about dose deviations from the dose constraint in the non-target volumes, and computing dose volume constraints for targets using a probability to control the dose distribution in the target volumes to be between a lower threshold and an upper threshold. Based on this information, the system obtains a robust chance-constrained treatment planning model with a user-adjustable tolerance level.

The invention relates to a rotating frame ion beam line layout structure and self-achromatic normal-temperature proton therapy equipment. Each of two self-achromatic units of the layout structure comprises two bending sections which are arranged in a mirror symmetry mode for deflecting a beam; at least one self-achromatic unit is an odd unit quadrupole lens group; the mirror symmetry center of theself-achromatic unit is a middle quadrupole lens; the self-achromatic unit are linearly provided with pairs of side quadrupole lenses with equal numbers; and the distances between the middle quadrupole lens and the adjacent side quadrupole lenses are the same, so that the middle quadrupole lens is used to eleminate chromatic aberration of a beam passing through the self-achromatic unit together with the two bending sections. The rotating frame ion beam line layout structure has a reasonable layout that beam lines are easy to assemble, the rotating frame ion beam line ensures that the motion trails of proton beams with different energies meet design requirements, and meanwhile, an effect of eliminating proton chromatic aberration is achieved.

The invention comprises a method and apparatus for aligning a charged particle beam path for treating a tumor of a patient, comprising: a cancer therapy system comprising the charged particle beam path sequentially passing: from an injector, through a synchrotron, along a beam transport line, and through a nozzle; a first two-dimensional detector configured to measure a beam state of positively charged particles; and an integrated intelligent system configured to classify the beam state into a set of beam shape factors, the integrated intelligent system configured to correct the beam shape through application of a condition-action rule: (1) adjusting a first voltage delivered to a first magnet positioned in the beam line prior to the first two-dimensional detector and (2) altering the beam shape through application of a second voltage to a second magnet position in the beam line adjacent to the first magnet.

A compact lightweight gantry for a proton therapy system that has a source-to-axis distance (SAD) of less than (2) m and can deliver a proton beam of superior quality. The reduced SAD leads to reducedrequirements on the maximum magnetic fields that can be generated by the bend magnets in the gantry beamline. Correspondingly, lightweight bend magnets can be used. The various components in the gantry beamline are optimized to achieve a beam spot size of approximately (4) mm sigma or less through a pencil beam scanning nozzle disposed downstream of the final bending magnet. In addition, the proton therapy system is configured to operate at a maximum beam energy in the range of (220-230) MeV.

The invention comprises a method and apparatus for tuning a charged particle beam path of a charged particle beam system used to treat a tumor of a patient, comprising the steps of: positioning a two-dimensional charged particle detector in a beam line downstream from a magnet pair; operating windings of the magnet pair at a first power level to generate a first magnetic field; measuring a beam position with the first two-dimensional charged particle detector; adjusting a correction magnetic field by driving voltage of a correction coil at a second power level, the second power level less than five percent of the first power level, where the first magnetic field and the correction magnetic field combine to yield an operational magnetic field; and the steps of measuring and adjusting the correction magnetic field changing the operational magnetic field to adjust a measured beam position toward a target beam position.

The invention discloses a method and system for adjusting the size of an isocenter beam spot of a rotating rack. The method comprises the steps: generating a beam current through an accelerator (in amode of convolution or synchrotron), carrying out the matching transmission of the beam current of a transmission line, and obtaining the parameters of the beam current at the inlet of the rotating rack, such as the size of the beam spot and the emittance; carrying out the matching of different mirroring scales according to the clinic required size adjustment parameters of the isocenter beam spotof the rotating rack under through a transmission matrix method under the conditions that the beam current matching parameters of the transmission line end at the inlet of the rotating rack are not changed and the magnet parameters of the transmission line are not changed, and dynamically adjusting the size of the isocenter beam spot. The method is built on the basis of the beam optics and the beam transmission matrix theory, and is reliable in design. The implementation scheme exerts small requirements for the engineering implementation, and is of great significance to the stabilization of the beam in a process of proton therapy.

A system for estimating a dose from a proton therapy plan includes a memory that stores machine instructions and a processor coupled to the memory that executes the machine instructions to subdivide arepresentation of a volume of interest in a patient anatomy traversed by a planned proton field into a plurality of voxels. The processor further executes the machine instructions to determine the distance from the source of the planned proton beam to one of the voxels. The processor also executes the machine instructions to compute the discrete contribution at the voxel to an estimated dose received by the volume of interest from the planned proton beam based on the distance between the source and the volume of interest.

The invention relates to a device and method used for remotely measuring a residual dose in a proton therapy system. The device mainly comprises a mobile measurement platform, a foldable and scalablesupport arm group and a Gamma ray dose detector; the mobile measurement platform comprises a platform main body carrying a power supply as well as moving wheels; the foldable and scalable support armgroup is formed by connecting a base on the platform main body with multiple foldable arms; a location or / and a detection distance of a to-be-measured point are determined by utilizing a photographicapparatus; the Gamma ray dose detector is arranged at a movable end of the support arm group, and a power line connected with the Gamma ray dose detector as well as a signal line are mounted in each foldable arm. The device provided by the invention has the effect of accurately measuring a residual dose rate of each therapy room in the proton therapy system.

Robust optimization systems and methods are provided for intensity modulated proton therapy (IMPT) that may be deployed in a clinically practical way to enable users to control the balance between nominal plan quality and plan robustness in a user-defined way. The method may include a normalized dose interval volume histogram (NDIVH)-based robust optimization, where the normalized dose interval (NDI) is calculated for each voxel considering dose variations in the face of uncertainties. It is then used to create a NDIVH. The area under this NDIVH curve may then be used to quantify plan robustness. By using normalized dose interval volume constraints (NDIVC) to control the shape of the NDIVH curves, plan robustness may be adjusted. The tradeoff between nominal plan quality and plan robustness can be modified in a user-defined way by adjusting positions of the NDIVCs on the NDIVH curves.

A system for testing docking performance of a low impact space docking sealing device comprises a low impact space docking performance testing device, a heating / refrigerating circulation machine, a vacuum pump, an atomic oxygen and plasma radiation environment simulation device, an electronic beam and proton beam radiation environment simulation device and an ultraviolet radiation environment simulation device; the atomic oxygen and plasma radiation environment simulation device, the electronic beam and proton beam radiation environment simulation device and the ultraviolet radiation environment simulation device are used for simulating a corresponding radiation environment of the space; the heating / refrigerating circulation machine is used for providing simulation testing environments under various temperature conditions; the vacuum pump is used for providing simulation of a space vacuum environment; and the low impact space docking performance testing device is used for simulating rendezvous and docking processes of a low impact space docking sealing test part under various load, speed and displacement boundaries. According to the system for testing the docking performance of thelow impact space docking sealing device, various space working condition environments can be simulated, and the docking performance can be sufficiently verified on the ground.