37 results about "Proton beam radiation" patented technology

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

The present application belongs to the technical field of high-end medical equipment. Disclosed are a multi-room particle therapy room, a radiotherapy system, and a particle accelerator movement method. The multi-room particle therapy room comprises a plurality of treatment rooms. The radiotherapy system comprises the multi-room particle therapy room and a particle accelerator. Each treatment room is provided with a beam window. The particle accelerator can move outside different treatment rooms and is aligned with the beam windows. The particle accelerator directs particle beams into the treatment rooms by means of the beam windows. The particle beams perform radiotherapy by means of therapy heads in the treatment rooms. The radiotherapy system is not provided with a dipole magnet or a quadrupole magnet. The plurality of treatment rooms share one particle accelerator. The particle accelerator is moved to the outside of the treatment room requiring the particle beam, and the particle beam is directed into the treatment room by means of the beam window. When the treatment in the treatment room is completed, the particle accelerator is moved to other treatment rooms requiring the particle beams and performs treatment work, thereby reducing the overall cost of the radiotherapy system and making proton therapy accessible.

The present disclosure provides a cone beam computed tomography system for proton therapy comprising an x-ray source configured to generate x-rays and positioned to rotate around a patient at a treatment isocenter, a detector assembly positioned opposite the x-ray source and configured to receive x-rays that have passed through the patient, a rotation mechanism configured to rotate the x-ray source and the detector assembly around the patient while maintaining their relative positions, a translation mechanism configured to translate at least one of the x-ray source, the detector assembly, or a patient couch during rotation to implement a wobbled scan orbit, and a scatter rejection grid attached to the detector assembly and focused on the x-ray source to reduce scattered x-rays. The translation mechanism distributes missing projection data across multiple radii and angles, enabling improved reconstruction quality through iterative reconstruction methods.

The invention discloses a proton treatment plan verification and optimization device and method and related equipment, and relates to the technical field of radiotherapy. The device comprises an image acquisition module which is used for acquiring a PET image of a patient after completing at least one proton treatment irradiation; the dose prediction module is used for mapping the treated PET image into actual deposited dose distribution in the body of the patient based on the trained generative model so as to predict actual distribution dose distribution; and the adjustment and optimization module is used for generating an adjusted fractional treatment plan when the deviation between the predicted actual distribution dose distribution and the initial planned dose distribution is greater than a deviation threshold value. Based on in-vivo measurement information, the actual deposition dose is accurately verified and dynamically optimized, and accurate and safe proton therapy is achieved.

This application discloses a three-dimensional dose reconstruction method and related equipment based on in-beam positron emission tomography (PET) data. The method includes: acquiring list-pattern data during proton therapy beam exit; performing conformation processing on the list-pattern data and reconstructing a three-dimensional activity distribution map; performing multi-nucleus dynamic deconvolution processing on the activity time series corresponding to the three-dimensional activity distribution map according to the physical half-life of the target nuclide and preset biological elution parameters to obtain the initial activity distribution corresponding to the target nuclide; mapping the initial activity distribution to a three-dimensional relative dose distribution using a preset dose mapping algorithm; converting the three-dimensional relative dose distribution into a three-dimensional absolute dose distribution according to a pre-established water phantom calibration curve; and generating a cumulative dose distribution report based on the three-dimensional absolute dose distribution. The embodiments of this application can reconstruct the three-dimensional absolute dose distribution with high accuracy and support inter-session dose accumulation analysis. This application can be widely applied in the field of dose reconstruction technology.

The application discloses a kind of fast energy regulation system and proton radiotherapy device for proton radiotherapy, belong to medical equipment technical field, including first quaternary iron, energy switching device and momentum cooling device sequentially arranged on energy beam transmission line, energy switching device includes sequentially connected first impact magnet, second quaternary iron, second impact magnet, energy switching energy reducer, third impact magnet and fourth impact magnet, first impact magnet is connected with first quaternary iron, fourth impact magnet is connected with momentum cooling device, energy switching energy reducer is one-piece wedge structure, it includes low-energy beam energy reduction zone, ideal beam energy reduction zone and high-energy beam energy reduction zone.It is simple in structure, energy switching time is short, transmission efficiency is high, and it can safely and efficiently transmit energy divergence less than 15%, energy is 70-230MeV proton, and transmission efficiency can reach 5%.

The application relates to the technical field of equipment motion control, and discloses a proton treatment rotating gantry motion control method, system, equipment and medium, the method comprises the following steps: in response to a gantry motion intention, performing pre-checking on a field programmable logic controller before motion, collecting a plurality of discrete input quantities and absolute angle feedback, and generating a safety snapshot; if the safety snapshot meets a motion prohibition condition, the motion is rejected and the reason is output; if the prohibition condition is not triggered, a target gantry angle and a speed given value are written to the PLC, and an ascending edge pulse is applied to a position starting coil to trigger the motion. It is determined whether the gantry is in place, after the gantry is in place, a standardized gantry public interlocking signal set is output to a treatment control layer, and the gantry is controlled to enter a stable standby state, and the treatment control layer calculates a proton beam emission permission based on the interlocking signal set. Through the safety snapshot pre-checking, mixed angle determination and standardized interlocking output, the motion control safety and positioning accuracy of the gantry are improved.

This invention relates to the field of radiation early warning technology, specifically to an early warning system for the radiation impact on the environment surrounding a proton therapy system. The system includes a radiation monitoring data acquisition module, a radiation spatial distribution generation module, a radiation risk level determination module, a radiation leakage analysis module, a dynamic risk information notification module, and a treatment optimization suggestion module. In this invention, by real-time monitoring and data integration of the radiation monitoring environment, the response speed and accuracy of radiation safety early warning are improved. By utilizing spatial data and radiation intensity information, a detailed radiation distribution map can be constructed, making risk assessment more intuitive and easier to understand. Accurate assessment of radiation risk allows for specific and targeted protective measures, and potential leakage points are classified according to radiation level deviations. Dynamic notification of risk information ensures that treatment personnel receive critical safety alerts in a timely manner, optimizing the treatment process and reducing the radiation risk to patients.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue invoves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, compact radiotherapy systems are provided that incorporate multi-function components, reducing bot equipment size and expense.

The application provides a kind of proton therapy system and its use method, the proton therapy system includes: treatment planning module, for generating irradiation data according to input treatment planning data;Beam control module, for generating the control parameter of accelerator module according to irradiation data and preset compensation data;Accelerator module, for generating proton beam current in response to control parameter;Measurement module, for measuring the actual current parameter of proton beam current;Treatment head, set in the path of proton beam current to target treatment location, to control the on-off of proton beam current path;Wherein, beam control module is also used to compare actual current parameter with target current parameter in irradiation data, and update compensation data based on comparison result, until the actual current parameter of proton beam current and target current parameter are the same according to updated compensation data.The application can enhance the treatment effect by determining the accuracy of dosimetric parameters through pre-checking process.

System and techniques may be adapted for use in composite field sequencing for proton therapy. A technique may include generating a proton therapy plan in a treatment planning system, the proton therapy plan including a plurality of static fields. The technique may include creating a single data file of a single dynamic field representing the plurality of static fields. The single data file may be sent to a proton therapy system for delivery of the single dynamic field. The technique may include receiving a response information related to a dose delivered to a patient by the single dynamic field.

Described herein are compact particle therapy systems comprising a superconducting cyclotron for proton therapy applications. In some aspects, an electromagnetic beamline incorporating energy selection systems and pencil beam scanning magnets directs particle beams from the cyclotron to a treatment isocenter. A patient positioning device comprising a robotic positioner with six degrees of freedom supports patient alignment, t. The particle system can be ultra compact and able to be installed in existing photon linear accelerator (e.g., radiation therapy) vaults.

To provide an accelerator and a proton beam treatment device capable of reducing an occupied area space of related components of a conductor and a water pipe of the accelerator.SOLUTION: An accelerator 1 includes a yoke 4, a conductor 21 connected to the yoke 4, and a water pipe 29 connected to the yoke 4, and the conductor 21 and the water pipe 29 are housed together in a cable carrier 25 arranged outside the yoke 4.SELECTED DRAWING: Figure 4

This invention discloses a matching method and related equipment for achieving beam dosimetric equivalence between multiple treatment chamber units, belonging to the field of proton and heavy ion radiotherapy technology. The method includes: acquiring beam physical characteristic parameters of each treatment chamber unit under multiple single-energy beam conditions covering the clinical treatment energy range; defining a reference benchmark; and determining a matching parameter set for the treatment unit to be matched, using the beam physical characteristic parameters of the reference benchmark as the target, so that its beam characteristics are adjusted to be overall equivalent to the reference benchmark in the multi-dimensional characteristic space; the matching parameter set includes physical additional module parameters and dose correction parameters. Through a hierarchical method of matching single-energy beams one by one, multi-energy comprehensive iterative optimization, and unified matching parameter output, dosimetrically equivalent treatment can be performed between multiple treatment chamber units without re-planning the treatment. This improves the cross-device versatility, treatment efficiency, and safety of multi-source multi-chamber proton radiotherapy systems, making proton therapy readily accessible.

Proton therapy system (1) for treating a patient (2) by means of proton radiation (3), comprising a particle accelerator (4) for generating a proton beam, a movable patient table (5) for holding and positioning a patient (2), a beam guidance device comprising several electromagnets (6) for focusing and / or defocusing and / or deflecting the proton beam (3), and a gantry (7) rotatable about a horizontal axis of rotation (R) for directing the proton beam (3) onto a target volume within a patient (2) held on the patient table (5), wherein the proton beam (3) has a maximum energy of less than 180 MeV, and the beam guidance device comprising a first scanner magnet (8A) and a second scanner magnet (8B) arranged in the direction of the proton beam behind the first scanner magnet (8A) for deflecting the proton beam (3), as well as a Proton beam direction between the scanner magnets (8A,8B) has a deflection magnet (9) arranged, wherein the deflection magnet (9) is configured to focus the proton beam (3) at the magnet input (9.1) in the plane of the beam deflection by the first scanner magnet (8A).

The application discloses a flat plate telescopic device integrated on a proton treatment head, characterized in that the flat plate telescopic device is integrated on both sides of a proton treatment head support through a motor and a mechanical transmission system and is arranged between an inverted trapezoidal front panel and an inverted trapezoidal rear panel on both sides of the proton treatment head; when an imaging system changes from a closed state to a working state, the flat plate telescopic device is unfolded along the proton treatment head support in an eight-shaped track from top to bottom and from inside to outside; when the imaging system changes from the working state to the closed state, the flat plate telescopic device is folded along the proton treatment head support in the eight-shaped track from bottom to top and from outside to inside, so that the integration of the flat plate telescopic device and the proton treatment head support is the integration in a limited space without interference with other devices. Since the flat plate telescopic device adopts the concave eight-shaped telescopic mode, the problem of insufficient space of the treatment head is solved, and the field angle of the imaging system can be increased and the resolution can be improved.

The utility model relates to the technical field of medical treatment, in particular to a breast cancer proton treatment body position fixing device which is detachably installed on a treatment bed and comprises a body bracket used for supporting the body of a patient and arranged on the treatment bed, and a headrest is installed on the body bracket; the angle adjusting mechanism is mounted on the treatment bed, connected with the body bracket and used for adjusting the placement angle of the body bracket relative to the treatment bed; the two arm brackets are symmetrically arranged on the two sides of the body bracket, the arm brackets are connected with multi-direction adjusting mechanisms installed at the side ends of the body bracket, and the multi-direction adjusting mechanisms are used for adjusting the vertical position and the horizontal position of the arm brackets. The arranged multi-direction adjusting mechanism can adjust the position of the arm bracket in the vertical direction and the horizontal direction, the distance between the arm of a patient and a mammary gland treatment area is adaptively increased, the path of a proton beam penetrating through the arm is remarkably reduced, and therefore the radiation dose received by the arm is reduced to the maximum extent.

This invention discloses a medical radiation-proof wall structure and construction method. The structure includes a first square tube connected to the roof structure and a second square tube connected to the floor structure. The first and second square tubes are connected by a third square tube to form a keel body. Multiple layers of lead plates are also provided on one side of the keel body. The keel body forms a closed structure to create a radiation-proof space. An adjustable gap exists between the first square tube and the roof structure. The bottom surface of the roof structure is connected to the side wall of the first square tube by a first angle steel to allow the decorative surface layer to fill the gap. This invention not only facilitates the construction of the decorative surface layer of a proton therapy center building structure but also effectively protects against radiation from highly penetrating proton therapy equipment.

Proton therapy treatment system to be deployed in an existing radiotherapy treatment vault such that radiation exposure is limited and meets radiation safety requirements. Patient support platform disposed in vault is configured for supporting patient, such as in a seated position. Imager is configured for imaging patient on patient support platform. A proton beam generator comprising a synchrotron is disposed in a region of vault. A proton beam delivery device is configured to deliver proton irradiation dose to isocenter of target tissue during treatment session, where delivery device may be gantry-less pencil beam scanning device operating without a collimator. Synchrotron may be disposed adjacent to entrance wall of vault and proton irradiation dose directed toward rear wall of vault. Synchrotron may extend through apertures of rear intermediate wall of vault and proton irradiation dose directed toward entrance intermediate wall of vault.

The invention belongs to the technical field of high-end medical equipment, and discloses radiotherapy equipment, a radiotherapy system and a control method, and the radiotherapy equipment comprises an outer rack, an inner rack, a first image guiding system and a second image guiding system. A particle accelerator is fixed on the outer rack, the inner rack is provided with a first end and a second end which are opposite to each other, and a treatment head is arranged on the inner rack. The first image guiding system comprises a first ray generating device and a first image processing device, the second image guiding system comprises a second ray generating device and a second image processing device, and the first ray generating device and the first image processing device are arranged close to the first end and the second end of the inner rack respectively. The second ray generating device and the second image processing device are arranged on the two sides of the inner rack respectively. According to the radiotherapy equipment, the overall duration of treatment is shortened, the use efficiency of the radiotherapy equipment is improved, the treatment effect is better ensured, and proton treatment is accessible.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

Radiation treatment planning for charged particle therapy systems, such as proton therapy systems, includes calculating dose distribution(s) using a virtual particle Monte Carlo (“VPMC”) dose calculation engine that utilizes virtual particles. Virtual particles inherit the physical properties from realistic particles, but are conceptually designed for parallel computing in graphics processing units (“GPUs”) by avoiding the simulation of secondary particles. Simulation of virtual particles instead of realistic particles takes full advantage of the GPU hardware architecture (e.g., by avoiding thread divergence and racing conditions).

The utility model discloses a special head and neck treatment bed board for proton radiotherapy, which relates to the technical field of medical instruments and is characterized in that the special head and neck treatment bed board comprises a bottom plate, the top of the bottom plate is integrally connected with a head, neck and shoulder placing plate, two convex columns are fixed on the bottom plate close to the head, neck and shoulder placing plate, and the two convex columns are symmetrically arranged relative to the middle of the bottom plate. A concave hole is formed in the head, neck and shoulder placing plate, a first through hole is formed in the position, close to the edge, of the head, neck and shoulder placing plate, a second through hole is formed in the edge of the bed board, and a third through hole is formed in the position, close to the middle of the bed board, of the head, neck and shoulder placing plate; according to the utility model, the whole body is integrally manufactured, the transverse and longitudinal physical thickness change of the bottom plate is small, the special convex columns are arranged for fixing the headrest, the headrest is fixed more stably, and the influence on the range and penumbra after protons pass through is small.

The application belongs to the technical field of high-end medical equipment, and discloses a radiotherapy device, a radiotherapy system and a control method, the radiotherapy device comprising: an outer gantry, an inner gantry, a first image guiding system and a second image guiding system. The outer gantry is fixed with a particle accelerator, the inner gantry has opposite first and second ends, and the inner gantry is provided with a treatment head. The first image guiding system comprises a first ray generating device and a first image processing device, the second image guiding system comprises a second ray generating device and a second image processing device, the first ray generating device and the first image processing device are arranged close to the first and second ends of the inner gantry respectively, and the second ray generating device and the second image processing device are arranged on both sides of the inner gantry. The radiotherapy device shortens the overall length of treatment, improves the use efficiency of the radiotherapy device, better ensures the treatment effect, and makes proton therapy accessible.

The utility model belongs to high -end medical instrument technical field discloses a cooling system and proton radiotherapy equipment. Cooling system is used to carry out cooling to proton radiotherapy equipment, and proton radiotherapy equipment includes compressor, accelerator and radio frequency system, and cooling system includes: first heat exchanger is configured as with the cooling compressor corresponding arrangement to cool the compressor, second heat exchanger is configured as with the accelerator corresponding arrangement to cool the accelerator, third heat exchanger is configured as with the radio frequency power amplifier corresponding arrangement to cool the radio frequency power amplifier, bypass valve, one end is configured as with the city tap water intercommunication, the other end with first heat exchanger intercommunication, and bypass valve can control compressor and first heat exchanger intercommunication or with city tap water intercommunication, cooling facilities, with first heat exchanger, second heat exchanger and third heat exchanger all intercommunication. The utility model can improve the overall stability and reliability when proton radiotherapy equipment works.

This invention discloses a treatment plan optimization method and related equipment based on deterministic coupling of respiratory motion, relating to the field of radiotherapy technology. The method includes: acquiring multi-temporal 4DCT sequences of the patient and corresponding respiratory motion curves; constructing a mapping relationship between respiratory phase and organ position; establishing a dynamic coupling mapping relationship between beam spot triggering time, respiratory phase, and anatomical position; constructing a 4D dose simulator based on the dynamic coupling mapping relationship to simulate the treatment plan and output a 4D cumulative dose distribution; comparing the 4D cumulative dose distribution with a preset clinical target, and if the error exceeds the tolerance range, activating an intelligent optimizer for optimization until the 4D cumulative dose distribution meets clinical requirements, and outputting the current treatment plan; achieving precise quantification and individualized adaptive compensation of the impact of respiratory motion, improving the realism of proton therapy dose deposition, the robustness of target coverage, and the optimization efficiency of the treatment plan.

This utility model discloses a rotating frame protective cover for a proton therapy device, including a base, wall panels, and a mounting base. The wall panels have an arc-shaped opening, and the mounting base is fixedly connected to an assembly plate coaxial with the opening. It also includes a sealed, spliced ​​outer protective plate, an inner protective plate, and a flexible protective plate. The outer edge of the outer protective plate connects to the arc-shaped opening, and the inner edge of the inner protective plate is fixed to the assembly plate, both sealingly fitting against the base. The outer and inner protective plates each have guide grooves, and the base has receiving grooves and matching inner and outer connecting grooves. The flexible protective plate slides into the guide grooves and connecting grooves to achieve dynamic sealing. This structure adopts a composite design of radiation-proof concrete and lead plates, combined with modular splicing and a sliding guide groove system, ensuring radiation protection while improving operational stability and maintenance convenience. Furthermore, the nested decorative panel design enhances aesthetics. This utility model has high shielding performance, durability, and adaptability, and can significantly improve the safety and reliability of proton therapy devices.

The invention discloses a radiation-proof concrete wall anti-cracking formwork system and a non-through-seam construction method, and belongs to the field of civil engineering. After the wall body is segmented, double-pump symmetrical layered pouring is performed; double staggered-platform rabbets are arranged between the sections to form nonlinear occlusion; a hollow partition component with a filling cavity is arranged in the path of the opposite-pull screw, and the radiation straight-through is cut off after concrete filling; the low-hydration-heat gel system is matched with real-time temperature measurement and adjustable heat preservation, and the temperature difference between the inside and the outside is smaller than or equal to 20 DEG C. The hollow partition component can be expanded into a stepped density inclined plane multi-layer prefabricated block, and the ray disturbing effect is improved. The ultra-thick anti-radiation wall has been applied to a wall body of a flaw detection room with the thickness of 2.65-3.10 m, realizes zero-through-joint and zero-penetrating-crack, meets the requirements of zero-through-joint, zero-leakage and zero-penetrating-crack, and is suitable for ultra-thick anti-radiation structures of nuclear facilities, proton treatment centers and the like.