79 results about "Proton beam radiation" patented technology

A system for treating a patient by proton therapy, also called gantry, includes a proton beam guide involving, in particular, magnets, quadropoles, and the like and having an outlet aperture for guiding and directing the proton beam to the side in the patient that is to be treated. In addition, a patient table that cab en displaced in a controllable manner is provided for moving the patient into a desired position relative to the proton beam. The inventive proton beam guide and control device is mounted down from the patient table in the direction of the beam guide in a supported manner whereby being able to rotate or pivot about a horizontal axis.

The invention relates a displacement-located double-stationary-chamber double-beam proton therapy system. Based on a cyclotron, two rotary rack therapy rooms and two double-stationary-beam-therapy chambers are provided, wherein one double-fixed-beam therapy chamber is combination of a horizontal beam and a vertical beam, and the other double-fixed-beam therapy chamber is combination of a horizontal beam and a 45-degree inclined beam. Due to the double-fixed-beam combination, the number of rotary racks can be reduced, and the construction cost can be greatly reduced; and due to the structure of double fixed beams, varieties of tumors which can be treated by the fixed beams can be greatly expanded. According to the displacement-located double-stationary-chamber double-beam proton therapy layout scheme for proton therapy, the equipment occupied space can be reduced, the construction cost for proton treatment devices can be greatly reduced, and the treatment effect can be ensured.

The invention discloses a proton beam flow intensity modulation method and system. In a proton therapy device based on a cyclotron, an energy selection module makes the transmission efficiency of the proton beam with different energies very different, but a treatment end requires the proton beam to maintain a stable flow intensity range. The method of the invention firstly obtains the beam loss and the transmission efficiency of the proton beam with different energies in an energy reduction process after the energy modulation of the proton beam, and obtains a flow intensity ratio from low energy to high energy. According to the clinical requirements of the proton beam flow intensity dynamic ratio, after different energy points which have been subjected to energy modulation undergo expansion and collimation, the flow intensity modulation within a design proportional region is completed and the flow ratio can be controlled within a certain value. The method and the system of the invention are based on the Monte Carlo calculation method and the beam optics. The design method is reliable, and the realization scheme has a small space requirement, which is important for maintaining the beam stability in the proton therapy process.

The invention comprises a method and apparatus for reducing a kinetic energy of positively charged particles, comprising the steps of: (1) transporting the positively charged particles from an accelerator into an exit nozzle system along a beam line; (2) providing a first chamber of the exit nozzle system, the first chamber comprising: an incident side comprising an incident aperture, an exit side comprising an exit aperture, and a beam path of the positively charged particles from the incident aperture to the exit aperture; (3) filling the beam path in the chamber with a liquid; and (4) using the liquid to reduce the kinetic energy of the positively charged particles. The kinetic energy dissipater is optionally used in combination with a proton therapy cancer treatment system and/or a proton tomography imaging system.

The present invention relates to an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide. An embolization particle of the invention for use in the treatment of cancer in combination with X-ray radiation or proton beam radiation, or use in embolization, is also described. The invention also relates to a process for producing an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide, which process comprises: (i) providing a microparticle; (ii) contacting the microparticle with a plurality of the nanoparticles; and (iii) heating the microparticle and the nanoparticles to form the embolization particle.

The invention discloses an emergency stop control method for a proton therapy patient positioning device. The method includes obtaining alarm information of a dangerous area in a patient positioning process, confirming whether a person enters the dangerous area of the treatment room according to the obtained alarm information of the dangerous area in the positioning process of the patient, the control unit determines whether or not a person enters the dangerous area based on the acquired information, when it is confirmed that a person has entered the dangerous area of the treatment room, controlling the patient positioning device to stop running, when it is determined that a person has entered a hazardous area, the control unit abruptly stopping the patient positioning device in the treatment room, when a signal is detected that may pose a threat to the safety of personnel, the operation of the positioning device can timely stopped, on the one hand, can avoid the injury of the personnel caused by the mechanical collision, on the other hand, can avoid the harm that the personnel are in the radiation area and irradiated by the radiation in the working process of the image system. Theinvention can improve the safety protection effect in the treatment room and avoid the safety accident in the treatment room.

The invention provides a parameter monitoring device and system for proton therapy. The device comprises a recurrent neural network module, a PET acquisition module, a prediction module, a judgment module and an adjustment module, wherein the recurrent neural network module provides a trained recurrent neural network model, and the trained recurrent neural network model provides a nonlinear relationship between positron nuclide activity distribution and dose distribution of a proton beam; the PET acquisition module acquires a PET image of the positron nuclide activity distribution generated bya reaction between protons and tissues from a positron annihilation tomography system; the prediction module inputs the PET image into the trained recurrent neural network model, and the dose distribution and Bragg peak position of the proton beam are predicted through the nonlinear relationship between the positron nuclide activity distribution and the dose distribution; the judgment module judges a position relationship between the predicted dose distribution and Bragg peak position of the proton beam and a target area; and the adjustment module judges whether beam outlet parameters of theproton beam need to be adjusted or not according to a judgment result of the judgment module. By the device and the system provided by the invention, parameter monitoring and adjustment for proton therapy are realized.

The invention discloses an accelerator safety interlock system for proton therapy. The accelerator safety interlock system for proton therapy comprises an upper computer PC, a switch, a PLC, a photoelectric conversion module and each subsystem of the accelerator; the upper computer PC is used for remotely monitoring and operating the state and operation of the accelerator subsystems, setting permissions and switching different modes at the same time, so as to facilitate the launching and debugging of the accelerator; the photoelectric conversion module converts an optical fiber signal into anelectrical signal that can be used by the PLC; each subsystem of the accelerator comprises a water cooling system, a lifting system, a superconducting magnet system, a vacuum system, an ion source system, an RF system and a lead-out zone system. The invention has the beneficial effects that: the hardware use and differentiation of the accelerator safety interlock system is very detailed, and is convenient to use; the system accelerator safety interlock system responds faster; and the accelerator safety interlock system is easier to use and operate, and has higher working precision.

The invention relates to a rotating frame ion beam line layout structure and self-achromatic normal-temperature proton therapy equipment. Each of two self-achromatic units of the layout structure comprises two bending sections which are arranged in a mirror symmetry mode for deflecting a beam; at least one self-achromatic unit is an odd unit quadrupole lens group; the mirror symmetry center of theself-achromatic unit is a middle quadrupole lens; the self-achromatic unit are linearly provided with pairs of side quadrupole lenses with equal numbers; and the distances between the middle quadrupole lens and the adjacent side quadrupole lenses are the same, so that the middle quadrupole lens is used to eleminate chromatic aberration of a beam passing through the self-achromatic unit together with the two bending sections. The rotating frame ion beam line layout structure has a reasonable layout that beam lines are easy to assemble, the rotating frame ion beam line ensures that the motion trails of proton beams with different energies meet design requirements, and meanwhile, an effect of eliminating proton chromatic aberration is achieved.

The invention comprises a method and apparatus for tuning a charged particle beam path of a charged particle beam system used to treat a tumor of a patient, comprising the steps of: positioning a two-dimensional charged particle detector in a beam line downstream from a magnet pair; operating windings of the magnet pair at a first power level to generate a first magnetic field; measuring a beam position with the first two-dimensional charged particle detector; adjusting a correction magnetic field by driving voltage of a correction coil at a second power level, the second power level less than five percent of the first power level, where the first magnetic field and the correction magnetic field combine to yield an operational magnetic field; and the steps of measuring and adjusting the correction magnetic field changing the operational magnetic field to adjust a measured beam position toward a target beam position.

The invention discloses a method and system for adjusting the size of an isocenter beam spot of a rotating rack. The method comprises the steps: generating a beam current through an accelerator (in amode of convolution or synchrotron), carrying out the matching transmission of the beam current of a transmission line, and obtaining the parameters of the beam current at the inlet of the rotating rack, such as the size of the beam spot and the emittance; carrying out the matching of different mirroring scales according to the clinic required size adjustment parameters of the isocenter beam spotof the rotating rack under through a transmission matrix method under the conditions that the beam current matching parameters of the transmission line end at the inlet of the rotating rack are not changed and the magnet parameters of the transmission line are not changed, and dynamically adjusting the size of the isocenter beam spot. The method is built on the basis of the beam optics and the beam transmission matrix theory, and is reliable in design. The implementation scheme exerts small requirements for the engineering implementation, and is of great significance to the stabilization of the beam in a process of proton therapy.

A system for estimating a dose from a proton therapy plan includes a memory that stores machine instructions and a processor coupled to the memory that executes the machine instructions to subdivide arepresentation of a volume of interest in a patient anatomy traversed by a planned proton field into a plurality of voxels. The processor further executes the machine instructions to determine the distance from the source of the planned proton beam to one of the voxels. The processor also executes the machine instructions to compute the discrete contribution at the voxel to an estimated dose received by the volume of interest from the planned proton beam based on the distance between the source and the volume of interest.

Robust optimization systems and methods are provided for intensity modulated proton therapy (IMPT) that may be deployed in a clinically practical way to enable users to control the balance between nominal plan quality and plan robustness in a user-defined way. The method may include a normalized dose interval volume histogram (NDIVH)-based robust optimization, where the normalized dose interval (NDI) is calculated for each voxel considering dose variations in the face of uncertainties. It is then used to create a NDIVH. The area under this NDIVH curve may then be used to quantify plan robustness. By using normalized dose interval volume constraints (NDIVC) to control the shape of the NDIVH curves, plan robustness may be adjusted. The tradeoff between nominal plan quality and plan robustness can be modified in a user-defined way by adjusting positions of the NDIVCs on the NDIVH curves.

The invention discloses a control console device for a superconducting proton therapy pencil beam treatment head. The control console device comprises a control panel, an input/output interface, a hardware circuit module and an upper monitoring system. The control panel realizes the command sending of beam preparation, request, termination and the like; the input/output interface can communicate with external equipment, can receive an external dose pulse signal, and can execute some trigger events; the hardware circuit module realizes the functions of data monitoring, control and state monitoring, fault diagnosis, safety interlocking and the like, and control console monitoring software communicates with the external equipment; and the upper monitoring system can communicate with a hardware circuit and a scanning dose system, and can monitor the current treatment state, dose information and basic parameter information in real time. The invention provides an operation and monitoring device for the superconducting proton therapy equipment pencil beam scanning treatment head, and aims to provide more convenient and visual equipment in the treatment process and improve the safety and reliability of the whole system.