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A strain of Lactobacillus paracasei that can alleviate or treat allergic diseases and its application

A Lactobacillus and paracheese technology, applied in the field of microorganisms, can solve the problems of easy recurrence of the disease and cannot change the course of allergic diseases, and achieve the effects of relieving clinical symptoms, reducing allergic rhinitis reactions, and improving inflammatory factor indicators

Active Publication Date: 2022-06-21
INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most important treatment for allergic diseases is drug therapy. Although it can relieve the disease to a certain extent, drug therapy cannot change the process of allergic diseases, and there is no long-term sustained drug effect after drug withdrawal, and the disease is prone to relapse , and long-term use of chemical drug treatment may have a negative impact on the body, so it cannot fundamentally achieve the effect of healing

Method used

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  • A strain of Lactobacillus paracasei that can alleviate or treat allergic diseases and its application
  • A strain of Lactobacillus paracasei that can alleviate or treat allergic diseases and its application

Examples

Experimental program
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Effect test

experiment example 1

[0024] Experimental Example 1 Animal Experiment of Lactobacillus paracasei PC-01 Relieving or Treating Allergic Rhinitis

[0025] 1 Experimental method

[0026] 1.1 Experimental strain preparation

[0027] Lactobacillus paracasei PC-01 powder preparation, the content of viable bacteria is 2×10 11 CFU / g.

[0028] 1.2 Experimental animals

[0029] The experiment used 6-month-old C57BL / 6J mice for the establishment of allergic rhinitis model.

[0030] 1.3 Main test kits

[0031] Ovalbumin (OVA), Hydroxide Adjuvant; ELISA Kit.

[0032] 1.4 Experimental Design

[0033] Mice were randomly divided into 3 groups and were treated with allergic rhinitis model respectively. The experimental methods were as follows:

[0034] Control group: eating sterile normal saline;

[0035] Allergic rhinitis group: sensitization by intraperitoneal injection of ovalbumin (20 μg) on ​​days 0 and 7, and nasal stimulation by intranasal injection of ovalbumin (200 μg) on ​​days 14-56;

[0036] Pro...

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Abstract

This application discloses a strain of Lactobacillus paracasei PC‑01 that can alleviate or treat allergic diseases and its application. The strain was deposited in the General Microbiology Center of the China Committee for the Preservation of Microorganisms on April 9, 2019, and its preservation number is It is CGMCC No.17537. The research on the prevention and treatment of allergic diseases carried out in this application with a rhinitis mouse model shows that Lactobacillus paracasei PC‑01 can regulate the intestinal immune system, thereby reducing the allergic rhinitis reaction caused by VOA, alleviating the clinical symptoms of patients, and effectively improving the Inflammatory factor index of rhinitis mouse model, which can relieve or treat allergic diseases.

Description

technical field [0001] The present application relates to the technical field of microorganisms, in particular to a strain of Lactobacillus paracasei that can alleviate or treat allergic diseases and its application. Background technique [0002] Allergic disease refers to a class of diseases in which the body produces a large amount of IgE after exposure to one or more sensitizing substances (allergens), thereby causing tissue or organ dysfunction or damage. It mainly includes allergic rhinitis, asthma, atopic Dermatitis, allergic gastrointestinal disorders and food allergies. Allergic diseases have become a common public health problem, and the incidence is increasing year by year, causing a huge medical burden to patients. At present, the most important treatment for allergic diseases is drug therapy. Although the disease can be relieved to a certain extent, drug treatment cannot change the course of allergic diseases, and there is no long-term continuous drug effect aft...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61P37/08A23C9/123A23L11/50A23G3/36A23L2/39A23L19/00A23L29/00A23L33/135C12R1/225
CPCC12N1/20A61K35/747A61P37/08A23L33/135A23C9/1234A23C20/025A23L29/065A23L19/00A23G3/366A23L2/39A23V2002/00C12R2001/225C12N1/205A23V2400/165A23V2200/304
Inventor 刘晓军马杰张凌宇张建军其木格苏都杨慧娟
Owner INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD