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Loxoprofen sodium gel and preparation method thereof

A technology of loxoprofen sodium and gel, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of high price and scarcity of loxoprofen sodium gel products and other issues to achieve the effects of reducing material loss, process optimization, and reducing preparation time

Pending Publication Date: 2020-09-04
JIANGSU FUBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Purpose of the invention: for the problems existing in the prior art, the present invention provides a kind of loxoprofen sodium gel and preparation method thereof, which solves the problems such as scarcity and high price of loxoprofen sodium gel products on the market, while guaranteeing self- The similarity of physical and chemical properties such as transdermal diffusion amount and appearance between the research product and the reference preparation

Method used

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  • Loxoprofen sodium gel and preparation method thereof
  • Loxoprofen sodium gel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment approach 1

[0013] This embodiment provides a kind of loxoprofen sodium gel, and its raw material comprises the following components by weight percentage:

[0014] components Dosage g percentage% loxoprofen sodium 0.286 1.144 carbomer 0.15 0.6 hypromellose 0.3 1.2 1.3 Butanediol 1.25 5 Triethanolamine 0.3 1.2 ethanol 2 8 water 20.714 82.856

[0015] The preparation method of above-mentioned loxoprofen sodium gel is as follows:

[0016] (1) wetting carbomer and hypromellose with 1.3-butanediol and ethanol;

[0017] (2) Add the water of 60% recipe quantity in step (1), stir until even while adding;

[0018] (3) Add an aqueous solution of triethanolamine prepared by triethanolamine and 10% prescription water into step (2), and keep stirring until uniform;

[0019] (4) Add the aqueous solution of loxoprofen sodium prepared by loxoprofen sodium and 10% prescription water to step (3), adjust the pH value to 6.2, and keep stirri...

Embodiment approach 2

[0022] This embodiment provides a kind of loxoprofen sodium gel, and its raw material comprises the following components by weight percentage:

[0023] Element Dosage g percentage% loxoprofen sodium 0.286 1.144 carbomer 0.25 1 hypromellose 0.2 0.8 1.3 Butanediol 1.25 5 Triethanolamine 0.3 1.2 ethanol 2 8 water 20.714 82.856

[0024] The preparation method of the above-mentioned loxoprofen sodium gel is roughly the same as Embodiment 1, except that in step (4), the aqueous solution of loxoprofen sodium is added, and after adjusting the pH value to 6.25, the stirring is continued until uniform. In addition, the preparation method of this embodiment is completely the same as Embodiment 1, and will not be repeated here.

Embodiment approach 3

[0026] This embodiment provides a kind of loxoprofen sodium gel, and its raw material comprises the following components by weight percentage:

[0027] Element Dosage g percentage% loxoprofen sodium 0.286 1.144 carbomer 0.35 1.4 hypromellose 0.1 0.4 1.3 Butanediol 1.25 5 Triethanolamine 0.3 1.2 ethanol 2 8 water 20.714 82.856

[0028] The preparation method of the above-mentioned loxoprofen sodium gel is roughly the same as Embodiment 1, except that in step (4), the aqueous solution of loxoprofen sodium is added, and after adjusting the pH value to 6.27, the stirring is continued until uniform. In addition, the preparation method of this embodiment is completely the same as Embodiment 1, and will not be repeated here.

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and discloses loxoprofen sodium gel, a preparation method of the loxoprofen sodium gel. The loxoprofen sodium gel comprisesthe following raw materials in weight percent: 1.144% of loxoprofen sodium, 0.4-1.4% of carbomer, 0.4-8.7% of hydroxypropyl methylcellulose, 5% of 1, 3-butanediol, 1.2% of triethanolamine, 8% of ethanol and the balance of water. Clear and transparent colloid with viscidity is prepared through a series of processes according to a specific proportion. Compared with the prior art, the process is short in technological process, easy to operate and suitable for industrial production. The product is clear and transparent in state, moderate in viscosity and good in transdermal diffusivity and skin absorbability.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a loxoprofen sodium gel and a preparation method thereof. Background technique [0002] Loxoprofen sodium, English name: Loxoprofen sodium gel, molecular formula C 15 h 17 NaO 3 .2H 2 O, structural formula: [0003] [0004] Loxoprofen sodium is very soluble in water and difficult to penetrate the stratum corneum. Therefore, the loxoprofen sodium gel can greatly increase the percutaneous penetration of loxoprofen sodium through preparation technology, and form a uniform and transparent gel that can be used for the treatment of arthritis, traumatic swelling, and pain. With the intensification of the aging society, the importance of drugs for the treatment of rheumatic bone disease pain has become increasingly prominent. Imported gel is expensive and has certain limitations, and loxoprofen sodium gel has not been approved for import in China so far, nor...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/216A61K47/18A61P19/08A61P29/00
CPCA61K9/0014A61K9/06A61K31/216A61K47/18A61P19/08A61P29/00
Inventor 黄金友何林受连黎明
Owner JIANGSU FUBANG PHARMA
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