Loxoprofen sodium gel and preparation method thereof
A technology of loxoprofen sodium and gel, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of high price and scarcity of loxoprofen sodium gel products and other issues to achieve the effects of reducing material loss, process optimization, and reducing preparation time
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Example Embodiment
[0012] Implementation mode 1:
[0013] This embodiment provides a loxoprofen sodium gel, the raw material of which includes the following components by weight percentage:
[0014] Component Dosage g percentage% Loxoprofen sodium0.2861.144 Carbomer0.150.6 Hypromellose0.31.2 1.3 Butanediol1.255 Triethanolamine0.31.2 Ethanol28 water20.71482.856
[0015] The preparation method of the loxoprofen sodium gel is as follows:
[0016] (1) Wet carbomer and hypromellose with 1.3-butanediol and ethanol;
[0017] (2) Add 60% of the prescription amount of water to step (1), and stir until uniform while adding;
[0018] (3) Add a triethanolamine aqueous solution prepared from triethanolamine and 10% of the prescription amount of water to step (2), and continue to stir until uniform;
[0019] (4) Add a loxoprofen sodium aqueous solution prepared from loxoprofen sodium and 10% of the prescription amount of water to step (3), adjust the pH to 6.2, and continue to stir until uniform;
[0020] (5) F...
Example Embodiment
[0021] Implementation mode 2:
[0022] This embodiment provides a loxoprofen sodium gel, the raw material of which includes the following components by weight percentage:
[0023] ingredient Dosage g percentage% Loxoprofen sodium0.2861.144 Carbomer0.251 Hypromellose0.20.8 1.3 Butanediol1.255 Triethanolamine0.31.2 Ethanol28 water20.71482.856
[0024] The preparation method of the loxoprofen sodium gel described above is roughly the same as that of Embodiment 1, except that in step (4), an aqueous solution of loxoprofen sodium is added, the pH value is adjusted to 6.25, and the stirring is continued until uniform. Except for this, the preparation method of this embodiment is completely the same as that of Embodiment 1, and will not be repeated here.
Example Embodiment
[0025] Implementation mode 3:
[0026] This embodiment provides a loxoprofen sodium gel, the raw material of which includes the following components by weight percentage:
[0027] ingredient Dosage g percentage% Loxoprofen sodium0.2861.144 Carbomer0.351.4 Hypromellose0.10.4 1.3 Butanediol1.255 Triethanolamine0.31.2 Ethanol28 water20.71482.856
[0028] The preparation method of the loxoprofen sodium gel described above is roughly the same as that of Embodiment 1, except that in step (4), an aqueous solution of loxoprofen sodium is added, the pH is adjusted to 6.27, and the stirring is continued until uniform. Except for this, the preparation method of this embodiment is completely the same as that of Embodiment 1, and will not be repeated here.
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