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Amino acid-modified galactomannan, and preparation method and application thereof

A galactomannan and amino acid technology, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations and other directions, can solve the problems of a large number of organic solvents, difficult to retain, and complicated operation of amino acid-modified polysaccharides, etc., and achieve a thickening effect. Good, maintain biological properties, good skin compatibility effect

Active Publication Date: 2020-09-04
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems existing in the existing methods of amino acid modified polysaccharides that a large amount of organic solvents are required, the operation is cumbersome and the biological properties of amino acids are difficult to be retained in the prepared amino acid modified polysaccharides, the present invention provides an amino acid modified galactomannan and its preparation Methods and Applications

Method used

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  • Amino acid-modified galactomannan, and preparation method and application thereof
  • Amino acid-modified galactomannan, and preparation method and application thereof
  • Amino acid-modified galactomannan, and preparation method and application thereof

Examples

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Embodiment 1

[0050] This embodiment provides a preparation method of amino acid modified galactomannan, comprising the following steps:

[0051] Step a, add 3.26g water and 12g NaOH (0.03mol) into the there-necked flask, mix well to obtain a sodium hydroxide solution with a mass concentration of 26.9%; add 1.5g glycine (0.02mol) into the above-mentioned three-necked flask, and stir until the glycine Dissolve everything, raise the temperature to 55°C, add 1.67g (0.018mol) of epichlorohydrin dropwise at a rate of 0.08mL / min, start to add epichlorohydrin, and react for 2 hours to obtain product a;

[0052] Step b, add 15.74 g of isopropanol aqueous solution with a mass concentration of 70% into another three-necked flask, add 0.4 g of NaOH (0.01 mol) and 6.44 g of guar gum (0.04 mol), stir for 50 min, and make it fully swell, Then the temperature was raised to 50°C, and the prepared product a was added dropwise for 20 minutes, and the reaction was continued for 100 minutes after the addition ...

Embodiment 2

[0058] This embodiment provides a preparation method of amino acid modified galactomannan, comprising the following steps:

[0059] Step a, add 4.8g water and 1.6g NaOH (0.04mol) into the there-necked flask, mix well to obtain a sodium hydroxide solution with a mass concentration of 25%; add 1.78g of alanine (0.02mol) into the above-mentioned three-necked flask, Stir until the alanine is completely dissolved, raise the temperature to 50°C, add 1.85g (0.02mol) of epichlorohydrin dropwise at a rate of 0.12mL / min, start to add epichlorohydrin dropwise, and react for 3h to obtain product a;

[0060] In step b, add 6.76 g of isopropanol aqueous solution with a mass concentration of 80% into another three-necked flask, add 0.16 g of NaOH (0.004 mol) and 3.22 g of guar gum (0.02 mol), stir for 60 min, and make it fully swell, Then the temperature was raised to 60°C, and the prepared product a was added dropwise for 10 minutes, and the reaction was continued for 50 minutes after the ...

Embodiment 3

[0064] This embodiment provides a preparation method of amino acid modified galactomannan, comprising the following steps:

[0065] In step a, add 3.23g of water and 1.44g of NaOH (0.036mol) into the three-necked flask, mix well to obtain a sodium hydroxide solution with a mass concentration of 30%; add 2.62g of leucine (0.02mol) into the above-mentioned three-necked flask, Stir until the leucine is completely dissolved, raise the temperature to 60°C, add 1.84g (0.02mol) of epichlorohydrin dropwise at a rate of 0.1mL / min, start to add epichlorohydrin dropwise, and react for 1h to obtain product a;

[0066] In step b, add 7.38 g of isopropanol aqueous solution with a mass concentration of 75% into another three-necked flask, add 0.8 g of NaOH (0.02 mol) and 1.61 g of guar gum (0.01 mol), stir for 30 min, and make it fully swell, Then the temperature was raised to 40°C, and the prepared product a was added dropwise for 30 minutes, and the reaction was continued for 2.5 hours af...

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Abstract

The invention relates to the technical field of polysaccharide modification, and particularly discloses amino acid-modified galactomannan, and a preparation method and application thereof. The preparation method at least comprises the following steps: dissolving amino acid in an alkaline solution, adding epoxy chloropropane, and carrying out a reaction at 50-60 DEG C for 1-3 h to obtain a producta; and adding galactomannan and strong base into an alcoholic solution, fully swelling the galactomannan and strong base, adding the product a, conducting reacting at 40-60 DEG C for 1-3 hours, and performing washing and drying to obtain the amino acid-modified galactomannan. The substitution degree of amino acid functional groups contained in the amino acid-modified galactomannan prepared by themethod is 0.3 to 1.5; the apparent viscosity of an aqueous amino acid-modified galactomannan solution with a mass content of 1 wt% is 2500-3200 mPa. S, and various amino acid surfactants can be effectively thickened; and the amino acid-modified galactomannan has the advantages of good skin compatibility, biodegradability and small irritation, and completely meets the requirements of daily chemicalproduct thickeners.

Description

technical field [0001] The invention relates to the technical field of polysaccharide modification, in particular to an amino acid modified galactomannan and its preparation method and application. Background technique [0002] In today's society, with the gradual depletion of petroleum resources, natural biodegradable materials have received more and more attention. Among them, galactomannan, as a natural polymer material, has many advantages such as low price, wide range of sources, and biodegradability, and has been widely used in many fields. Galactomannan is composed of mannose linked by β-1,4-glycosidic bonds, and galactose is linked on the main chain by α-1,6-glycosidic bonds, with an α every few mannose residues -D-galactose is connected to the main chain with 1,6 bonds. Galactomannose is mainly derived from fenugreek gum, guar gum, guanhua bean gum, locust bean gum, carob bean gum and tara gum, all of which have galactomannans with different degrees of branching. ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K8/73A61Q5/02
CPCC08B37/0087C08B37/0096C08B37/0093A61K8/737A61Q5/02A61K2800/48
Inventor 王若琳徐玉枫盖军旗牛春梅
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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