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Thermal desorption electrospray ion source with enrichment function

An electrospray ion source and thermal analysis technology, applied in the direction of ion source/gun, circuit, discharge tube, etc., can solve the problems of limited detection sensitivity, affecting the efficiency of heating and gasification, and can not significantly improve the sensitivity of ion source, so as to improve Detection sensitivity and the effect of increasing the injection volume

Active Publication Date: 2020-09-04
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, although the sampling volume can be increased by increasing the size of the sampling needle, too large sampling volume will affect the efficiency of heating and vaporization, and cannot significantly improve the sensitivity of the ion source
In summary, the limited detection sensitivity is a major problem to be solved in the existing thermal desorption electrospray ion sources

Method used

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  • Thermal desorption electrospray ion source with enrichment function
  • Thermal desorption electrospray ion source with enrichment function
  • Thermal desorption electrospray ion source with enrichment function

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0024] Such as figure 2 As shown, a thermal desorption electrospray ion source with enrichment function includes a thermal desorption unit, an electrospray unit 1 and a detection unit 2, and the electrospray unit and the detection unit are arranged facing each other, forming a gap between the electrospray unit and the detection unit. In the ionization area 3, the sample to be detected passes through the thermal analysis unit to form a sample gas and enters the ionization area, and forms sample ions under the action of the electrospray unit to enter the detection unit for detection. The detection unit in this embodiment is a mass spectrometer.

[0025] The thermal analysis unit includes a metal cavity 4, a sampling probe 5, an enrichment pipe 6, a first temperature control device, a second temperature control device, a connecting pipeline 7, and an air inlet device 8. The inner upper end of the metal cavity is provided with an inlet The sample chamber 9, the needle 10 at the l...

Embodiment 2

[0027] This embodiment proposes a thermal desorption electrospray ion source with enrichment function, which limits the specific structures of the first temperature control device and the second temperature control device on the basis of the first embodiment. In this embodiment, the first temperature control device includes a heating rod 12 and a temperature measuring rod 13, the heating rod and the temperature measuring rod are arranged inside the metal cavity and distributed on the relative positions of the periphery of the sampling chamber, and the temperature measuring rod It is used to measure the air temperature in the sampling chamber and feed it back to the control system. The heating rod is used to heat the air temperature in the sampling chamber to the set temperature. They cooperate with the control circuit to complete the thermal temperature control function of the sampling chamber.

[0028] In this embodiment, the second temperature control device includes a cerami...

Embodiment 3

[0030] This embodiment proposes a thermal desorption electrospray ion source with enrichment function, which further defines the specific structure of the sealing mechanism on the basis of the first embodiment. In this embodiment, the sealing mechanism includes a fixed end 16 and a sealing ring 17, the fixed end is set under the metal cavity and sleeved outside the lower end of the enrichment tube, and the seal ring is set between the enrichment tube and the metal cavity Between them, it is used to airtightly fix the enrichment chamber. The inner wall of the fixed end is provided with an internal thread, and the bottom end of the metal cavity is provided with an external thread 18. The internal thread and the external thread cooperate to connect the enrichment tube and the metal The cavity is fixed, and at the same time, the fixed end compresses the sealing ring.

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Abstract

The invention discloses a thermal desorption electrospray ion source with an enrichment function. The thermal desorption electrospray ion source comprises a thermal desorption unit, an electrospray unit, a detection unit and an ionization region, wherein a sample passes through the thermal desorption unit to form a sample gas, the sample gas enters the ionization region, sample ions are formed under the action of the electrospray unit and enter the detection unit, the thermal desorption unit comprises a metal cavity, a sampling probe, an enrichment pipe, a first temperature control device, a second temperature control device, a connecting pipeline and an air inlet device, a sample injection chamber and the first temperature control device are arranged at the upper end of the metal cavity,the needle head of the sampling probe extends into the sample injection chamber, an enrichment chamber is arranged at the lower end of the metal cavity, the enrichment pipe is arranged in the enrichment chamber, the lower end of the enrichment pipe is aligned with the ionization region, the second temperature control device is arranged outside the enrichment pipe, the connecting pipeline is communicated with the sample injection chamber and the enrichment chamber, and the air inlet device blows air into the sample injection chamber. The thermal desorption electrospray ion source has the advantages that sample enrichment is performed in advance, so that the detection sensitivity of the thermal desorption electrospray ion source is greatly improved.

Description

technical field [0001] The invention relates to an atmospheric pressure ion source for a mass spectrometer, in particular to a thermal analysis electrospray ion source with enrichment function. Background technique [0002] Mass spectrometer is an analytical instrument that uses the charge-to-mass ratio to separate and detect substances, and is widely used in food safety, pharmaceuticals, life sciences and other fields. A mass spectrometer generally consists of an ion source, a mass analyzer, a detector, and a vacuum system. The analyte is first ionized by the ion source into charged ions, and then the ions are guided into the mass analyzer in a vacuum environment. The mass analyzer is responsible for separating the ions according to the charge. The mass ratio is separated and sent to the detector in turn. After the signal obtained by the detector is amplified, collected and processed, the computer draws a complete mass spectrum. [0003] Atmospheric pressure ion source is ...

Claims

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Application Information

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IPC IPC(8): H01J49/16
CPCH01J49/165Y02A50/20
Inventor 吴焕铭唐科奇
Owner NINGBO UNIV