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An irradiation method and system

A technology of irradiation and target, applied in the field of irradiation methods and systems

Active Publication Date: 2020-09-04
AUSTRALIAN NUCLEAR SCI & TECH ORGANISAT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with this technique the treatment depth exceeds Approximately 3 cm of tissue is not viable [22]

Method used

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  • An irradiation method and system

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Experimental program
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Embodiment 1

[0148] To demonstrate the feasibility of this approach, the generation of neutrons under proton or heavy ion irradiation and the generation of neutrons containing 10 The composition of B absorbs these neutrons. This is done to determine the neutron fluence produced by typical forms of proton or heavy ion irradiation, and therefore the applications for which this neutron fluence can be used.

[0149] I. Materials and methods

[0150] All Monte Carlo simulations were performed using the Geant4 toolkit (version 10.2.p03) [23, 24]. Electromagnetic interactions were modeled using the standard Geant4 physics option 3 model (G4EmStandardPhysics option 3), while the hadron physics models used in the simulations are listed in Table I.

[0151] Table I: Hadron physics models used in all simulations

[0152]

[0153]

[0154] Part B of I (below) examines the use of monoenergetic protons with different energies, 12 C and 16 Three-dimensional distribution of thermal neutron flue...

Embodiment 2

[0220] In a further embodiment, a similar set of simulations were performed. Significance was arbitrarily defined as an average 10% increase in intratumoral photon-equivalent dose due to administration of a non-toxic neutron harvester bolus (although it is contemplated that the method of present practice can be used with any desired dose-increase factor). To this end, for a simple simulated therapeutic proton / heavy ion therapy plan, the neutron capture agent concentration required to deliver a 10% increase in effective photon-equivalent dose was determined and compared with concentrations reported in the literature.

[0221] The first step is to evaluate the neutron fluence produced by the pencil beam at a point within the target volume. In a homogeneous PMMA target, four different energies are used to pair the proton beam and 12 A set of simulations were performed for this pencil beam of the C-beam. The dose and neutron fluence distributions are recorded for each simulation...

Embodiment 3

[0276] The approach of the foregoing embodiments was experimental testing. A series of proof-of-concept experiments were performed at the HIMAC facility in Japan to quantify the effective increase in biological dose that can be achieved in vitro. Cultured T98-G cancer cells adhered to the inner surface of T25 cell culture flasks were irradiated in carbon and helium ion beams in the presence and absence of practical concentrations of neutron capture agents.

[0277] Three frozen vials of the T98G (JCRB9041, human glioblastoma multiforme) cell line were purchased from the National Institute for Biomedical Innovation, Health and Nutrition, JCRB Cell Bank and used throughout the experiments.

[0278] Cells were revived and passaged twice before the experiment was started, and then 160 T25 flasks were inoculated with 5 mL of complete growth medium (DMEM+10% FBS). Place the flask at 5 ± 1% CO 2 Incubate at 37±1°C in an atmosphere.

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Abstract

An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at thetarget volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.

Description

[0001] related application [0002] This application is based on and claims the benefit of the filing date and priority date of AU Application No. 2017903739, filed September 14, 2017, the contents of which filing are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates to irradiation methods and systems, particularly but not exclusively for use in the irradiation of biological material. Background technique [0004] The primary goal of all forms of radiation therapy is to deliver the maximum therapeutic radiation dose to the target while sparing surrounding healthy tissue. One of the greatest challenges of radiation therapy is minimizing its potential effects, including the risk of secondary cancers, which can occur five to decades after treatment [1-4]. The goal is to minimize the normal tissue complication probability (NTCP), which includes the possibility of developing treatment-induced cancer, by maximizing the con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10A61N5/01G21G1/04
CPCG21K5/04G21K1/093H05H13/10A61N5/1031H05H13/005H05H13/04A61N5/1078A61N2005/1087A61N2005/1034A61N5/1039A61N2005/109A61N5/10G21G4/02A61N5/103A61N2005/1098A61K41/0095A61K41/009A61N5/1065H05H7/10
Inventor M·萨法维纳伊尼A·S·查肯
Owner AUSTRALIAN NUCLEAR SCI & TECH ORGANISAT
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