Preservation and transportation liquid for decellularized lamellar corneas
A technology of lamellar cornea and transport fluid, which is applied in the field of preservation and transportation of medical materials, can solve the problems of unsuitable preservation of acellular lamellar cornea, achieve the effect of no cytotoxicity, small molecular weight, and increase colloid osmotic pressure
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Embodiment 1
[0026] The storage and transportation solution of this embodiment includes the following components in weight percentage: 65% glycerin, 6% dextran with a molecular weight of 20,000 to 40,000, 0.2% N-acetylcysteine, and the balance is deionized water .
[0027] The preparation method of the acellular lamellar cornea storage transport solution in this example is: dissolving N-acetylcysteine and dextran with a molecular weight of 20,000 to 40,000 in deionized water, and adjusting the pH value of the solution after mixing evenly to 7.2, then add glycerin and mix well.
[0028] The acellular lamellar cornea with a thickness of 0.49 mm is preserved by using the preservation and transportation solution of this embodiment. One month later, the thickness of the cornea was measured to be 0.48±0.08mm. The preserved cornea had good transparency, no yellowing, and maintained good thickness, toughness and elasticity, and no swelling after rehydration.
Embodiment 2
[0030] The storage and transportation solution of this embodiment includes the following components in weight percentage: 65% glycerin, 2% chondroitin sulfate, 0.5% sodium hyaluronate with a molecular weight of 200,000 to 400,000, and about 20,000 to 40,000 molecular weight. Glucoside 6%, N-acetylcysteine 0.2%, and deionized water as the balance.
[0031] The preparation method of the acellular lamellar cornea storage transport solution in this example is: dissolving N-acetylcysteine, chondroitin sulfate, sodium hyaluronate and dextran with a molecular weight of 20,000 to 40,000 in deionized water, adjust the pH value of the solution to 7.2 after mixing evenly, then add glycerin and mix evenly.
[0032] The acellular lamellar cornea with a thickness of 0.49mm is preserved by using the preservation and transportation solution of this embodiment. After one month, the thickness of the cornea was measured to be 0.48±0.05mm. After preservation, the cornea had good transparency, ...
Embodiment 3
[0034] The storage and transportation solution of this embodiment includes the following ingredients in weight percentage: 65% glycerin, 6% chondroitin sulfate, 0.2% N-acetylcysteine, and the balance is deionized water.
[0035] The preparation method of the acellular lamellar cornea storage transport solution in this example is as follows: dissolve N-acetylcysteine and chondroitin sulfate in deionized water, mix well, adjust the pH value of the solution to 7.2, and then add glycerin and mix well .
[0036] The decellularized lamellar cornea was preserved using the preservation and transport solution of this embodiment, and the cornea after preservation for 3 months had good transparency and no yellowing phenomenon (see figure 1 ), and can maintain good thickness, toughness and elasticity, and will not swell after rehydration.
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