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Novel medical trauma auxiliary material and preparation method

A technology for trauma and excipients, which is applied in pharmaceutical formulations, medical science, and absorbent pads. It can solve the problems of poor flexibility and mechanical strength, and the variability and failure of drug-loaded excipients, so as to improve the action time and prevent moisture and protein on the wound surface. Loss, infection prevention effect

Inactive Publication Date: 2020-09-22
中国科学院大学深圳医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems of the variability and failure of existing drug-loaded adjuvants, and poor flexibility and mechanical strength after drug loading, the present invention provides a new type of medical trauma adjuvant, through the double-layer design of silicone membrane-PEG / PLGA composite nanofiber membrane And choose Masang extract as the drug type, which can not only effectively prevent the denaturation and failure of the drug-loaded excipients, but also improve the action time of the excipients, help the release of the drug and improve the flexibility and mechanical strength of the excipients

Method used

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  • Novel medical trauma auxiliary material and preparation method
  • Novel medical trauma auxiliary material and preparation method
  • Novel medical trauma auxiliary material and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] The medical wound auxiliary material provided in this example is composed of two layers, the upper layer is a silicone membrane, and the lower layer is a PEG / PLGA composite nanofiber membrane; the PEG / PLGA composite nanofiber membrane is loaded with the drug Masang extract;

[0036] The preparation method of the above-mentioned medical wound auxiliary materials is as follows:

[0037] 1) Preparation of spinning solution:

[0038] Configure a mixed solvent of N-N-methylpropylamine, acetone and chloroform, wherein the volume ratio of N-N-methylpropylamine, acetone and chloroform is 3:5:2;

[0039] Weigh 0.1-0.7g of polylactic acid-glycolic acid copolymer and 0.3-0.6g of polyethylene glycol particles into 100ml of N-N-methylpropylamine, acetone and chloroform mixed solvent, the polylactic acid- The sum of the mass concentration of glycolic acid copolymer and polyethylene glycol particles in the mixed solvent is 26% to 30% w / v, stirred at 37-45°C for 1.5-2h, and then added...

Embodiment 2

[0053] In order to prove the high porosity and pore connectivity of the nanofiber membrane in the lower layer, the nanofiber membrane and the drug-loaded nanofiber membrane were characterized respectively.

[0054] The non-drug-loaded fibrous membrane was prepared as follows:

[0055] 1) Preparation of spinning solution:

[0056] Configure a mixed solvent of N-N-methylpropylamine, acetone and chloroform, wherein the volume ratio of N-N-methylpropylamine, acetone and chloroform is 3:5:2;

[0057] Weigh 0.1-0.7g of polylactic acid-glycolic acid copolymer and 0.3-0.6g of polyethylene glycol particles into 100ml of N-N-methylpropylamine, acetone and chloroform mixed solvent, the polylactic acid- The sum of the mass concentration of glycolic acid copolymer and polyethylene glycol particles in the mixed solvent is 26% to 30% w / v, stirred at 37-45°C for 1.5-2h, and left to defoam to obtain PEG / PLGA mixed precursor solution;

[0058] 2) Electrospinning the spinning solution in step...

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Abstract

The invention discloses a preparation method of a novel medical trauma auxiliary material, and belongs to the technical field of novel medical trauma auxiliary materials. The medical trauma auxiliarymaterial is composed of two layers, wherein the upper layer is a silicone membrane, the lower layer is a PEG / PLGA composite nanofiber membrane, and the PEG / PLGA composite nanofiber membrane is loadedwith a coriaria sinica extract. The method is characterized by comprising the following steps of 1) preparing a PEG / PLGA mixed spinning solution containing the coriaria sinica extract; 2) preparing the silicone membrane; 3) enabling the silicone membrane to be adhered to an aluminum foil, and to be fixed on a roller receiver of an electric spinning machine, and performing electrostatic spinning onthe mixed spinning solution in the step 1); and 4) performing drying on the sample for a certain time after spinning. According to the method disclosed by the invention, a double-layer design is adopted, and the coriaria sinica extract is selected as a drug type, so that denaturation failure of the drug-loaded auxiliary material can be effectively prevented, and the action time duration of the drug property of the auxiliary material and the flexibility and mechanical strength of the auxiliary material can be improved.

Description

technical field [0001] The invention belongs to the technical field of medical wound auxiliary materials, and more specifically relates to a novel medical wound auxiliary material and a preparation method thereof. Background technique [0002] The preparation technology of medical excipients is in the stage of development and perfection in the world. It has shown in anti-pollution, anti-soaking, absorbing liquid exuded from wounds, maintaining a moist environment on the wound, maintaining good air permeability, good biocompatibility, and antibacterial activity. Bright development and application prospects. Existing wound accessories mainly include two types of second-generation accessories and third-generation accessories. Among them, the second-generation excipients are wet excipients, mainly including transparent film excipients, hydrocolloid excipients, hydrogel excipients, alginate excipients, foam excipients, etc., which can induce fibroblasts and keratinocytes based o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/40A61L15/42
CPCA61L15/26A61L15/40A61L15/42A61L15/425A61L2400/12C08L83/04C08L67/04
Inventor 李茹冰丘海轶吴云赵月林海洋何丹丹梁瑶邹银萍毛勤荣
Owner 中国科学院大学深圳医院
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