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Preparation of porosity electrospun fiber

An electrospun fiber and porous technology, which is applied in the field of preparation of porous electrospun fibers, can solve problems such as application limitations, and achieve the effects of good shape, broad application prospects and simple operation.

Inactive Publication Date: 2011-05-25
JIANGSU CHANGJIYONG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparation methods of porous electrospun fibers are subject to certain application restrictions due to the differences in the phase separation speed of the polymer solution and the solvent volatilization speed, as well as the difference in the solubility properties of the polymer.

Method used

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  • Preparation of porosity electrospun fiber
  • Preparation of porosity electrospun fiber
  • Preparation of porosity electrospun fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, preparation of porous electrospun fiber membrane

[0027] Include the following steps:

[0028] a, preparation of electrospinning solution: dissolving polycaprolactone (PCL) in methanol to make a solution with a mass volume percentage of 5%, adding sodium chloride (NaCl) with a particle size of 1 μm in the solution to make PCL and NaCl The mass ratio of the mixture is 1:1, and the mixture is evenly mixed to obtain the PCL / NaCl mixed electrospinning solution;

[0029] b. Electrospinning: use the electrospinning equipment (with stainless steel metal plate as the receiver) of the PCL / NaCl mixed electrospinning solution in step a at an applied voltage of 20KV, a flow rate of the electrospinning solution of 0.01mL / min, and a receiving distance of 5cm Electrospinning was carried out under certain conditions to obtain PCL / NaCl composite electrospun fibers, and the receiver collected the fibers for 60 minutes to obtain PCL / NaCl composite electrospun fiber membran...

Embodiment 2

[0032] Embodiment 2, preparation of porous electrospun fiber membrane

[0033] Include the following steps:

[0034] a, preparation of electrospinning solution: dissolving PCL in chloroform to make a solution with a mass volume percentage of 9%, adding calcium carbonate (CaCO3) with a particle size of 100nm in the solution 3 ) make PCL and CaCO 3 The mass ratio of the mixture is 1:1, mix evenly to get PCL / CaCO 3 Mixed electrospinning solution;

[0035] b. Electrospinning: the PCL / CaCO of step a 3 The electrospinning equipment (using stainless steel metal plate as the receiver) for the mixed electrospinning solution was electrospun under the conditions of an applied voltage of 20KV, a flow rate of the electrospinning solution of 0.015mL / min, and a receiving distance of 15cm to obtain PCL / CaCO 3 Composite electrospun fibers, the receiver collected the fibers for 60 minutes, and obtained PCL / CaCO with randomly arranged fibers 3 Composite electrospun fiber membrane;

[0036] c...

Embodiment 3

[0038] Embodiment 3, preparation of porous electrospun fiber membrane

[0039] Include the following steps:

[0040] a, preparation of electrospinning solution: dissolving polyglycolic acid (PGA) in hexafluoroisopropanol to make a solution with a mass volume percentage of 10%, adding sodium bicarbonate (NaHCO 3 ) make PGA with NaHCO 3 The mass ratio of the mixture is 2:1, mix evenly to get PGA / NaHCO 3 Mixed electrospinning solution;

[0041] b, electrospinning: the PGA / NaHCO of step a 3 Electrospinning equipment (with stainless steel metal plate as the receiver) was used to electrospin the mixed electrospinning solution under the conditions of an applied voltage of 5KV, a flow rate of the electrospinning solution of 0.02mL / min, and a receiving distance of 5cm to obtain PGA / NaHCO 3 Composite electrospun fibers, the receiver collects the fibers for 60 minutes, and obtains PGA / NaHCO with randomly arranged fibers 3 Composite electrospun fiber membrane;

[0042] c, salting ou...

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Abstract

The invention discloses a preparation method of porosity electrospun fiber, suspending nano salt uniformly into polymer solution and proceeding electrospinning to obtain polymer / nano salt composite electrospun fiber, then using elution solution of the nano salt to proceed salt out, removing the nano salt and producing holes to obtain the porosity electrospun fiber. The method is provided with simple operation, low cost and less environmental pollution which is suitable for industrial production; the obtained porosity electrospun fiber has good shape, and can change pore diameter and surface roughness of electrospun fiber conveniently by changing particle diameter and dosage of nano salt, which can be used for preparing medicine molecular vehicle, tissue engineering stand, tissue repair replacement etc. The invention has wide application foreground.

Description

technical field [0001] The invention relates to the field of materials, in particular to a method for preparing porous electrospun fibers. Background technique [0002] Ultra-high specific surface area fiber materials have broad application prospects in high-efficiency chemical and biological adsorption separation materials, catalytic carriers, high-efficiency sensors, cell and drug molecule carriers, tissue engineering scaffolds, and tissue repair substitutes. [0003] Reducing the fiber diameter and / or creating pores on the fibers can increase the specific surface area of ​​the fiber material. The specific surface area of ​​ordinary fiber materials is about 0.1m 2 / g, when the fiber diameter is reduced to 100nm, the specific surface area of ​​the fiber material can be increased to about 44m 2 / g. Electrospinning is a simple and effective method to prepare fibers with diameters from nanometers to micrometers, but it is still difficult to prepare a large number of fibers ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D1/02D01D5/00D01D10/00A61K47/42A61K47/36A61K47/34
CPCD01F1/10D01D5/0007D01D5/247
Inventor 王伯初王亚洲
Owner JIANGSU CHANGJIYONG BIOTECH CO LTD
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