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Traditional Chinese medicine composition for treating rash caused by antitumor drugs

A technology of anti-tumor drugs and compositions, applied in anti-tumor drugs, drug combinations, drug delivery, etc., can solve the problems of ignoring the overall survival of patients, lack of high-quality clinical research evidence support, and inaccurate clinical efficacy, etc. Safety, improve the quality of life, positive curative effect

Active Publication Date: 2020-09-25
浙江省中医院、浙江中医药大学附属第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For skin rashes caused by anti-tumor drugs at home and abroad, the clinical efficacy is uncertain, lack of high-quality clinical research evidence support, some studies only stay in clinical experience and preventive drug research, lack of consideration of the intensity of anti-tumor treatment, and ignore the overall survival of patients

Method used

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  • Traditional Chinese medicine composition for treating rash caused by antitumor drugs
  • Traditional Chinese medicine composition for treating rash caused by antitumor drugs
  • Traditional Chinese medicine composition for treating rash caused by antitumor drugs

Examples

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Comparison scheme
Effect test

Embodiment 1

[0042] Prescription: 15g southern yew, 20g coix seed, 20g honeysuckle, 20g reed stem, 15g angelica, 12g trichosanthes, 15g scrophulariaceae, 6g angelica, 12g licorice;

[0043] Preparation method: take the raw material according to the proportion, add 10 times the quality of water, decoct twice, filter to get the filtrate, concentrate, filter, and pack into 100ml / bottle.

[0044] Usage: Apply directly on the rash site.

Embodiment 2

[0046] Prescription: 18 parts by weight of southern yew, 30 parts by weight of coix seed, 30 parts by weight of honeysuckle, 30 parts by weight of reed stem, 20 parts by weight of angelica, 15 parts by weight of trichosanthin, 20 parts by weight of Scrophulariaceae, 9 parts by weight of Angelica dahurica, 15 parts by weight of licorice share;

[0047] Preparation method: Take the raw material drug in proportion, extract twice with 50% ethanol under reflux, combine the extracts, filter, recover ethanol, add water to dissolve, concentrate under reduced pressure to a density of 1.10 (60°C), centrifuge at high speed, take the supernatant, add conventional Excipients are made into preparations for external use.

[0048] Usage: Apply directly on the rash area.

Embodiment 3

[0050] Prescription: Southern yew 9g, coix seed 10g, honeysuckle 10g, reed stem 10g, angelica 10g, trichosanthes 9g, scrophulariaceae 9g, angelica dahurica 3g, licorice 5g;

[0051] Preparation method: with the preparation method of embodiment 1.

[0052] Usage: Apply directly on the rash area.

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Abstract

The invention provides a traditional Chinese medicine composition for treating rash caused by antitumor drugs. The traditional Chinese medicine composition comprises the following components in partsby weight: 9-18 parts of taxus chinensis, 10-30 parts of semen coicis, 10-30 parts of honeysuckle, 10-30 parts of reed stem, 10-20 parts of angelica sinensis, 9-15 parts of radices trichosanthis, 9-20parts of radix scrophulariae, 3-9 parts of radix angelicae and 5-15 parts of liquorice. The traditional Chinese medicine composition can be used for remarkably improving and curing the rash caused bythe antitumor drugs in a short period of time, is safe to use and definite in curative effect, and can be used for remarkably improving the life quality of patients on the premise of not reducing theantitumor treatment intensity.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating rashes caused by antineoplastic drugs. Background technique [0002] With the rapid development of precision medicine today, skin adverse reactions caused by anti-tumor drugs are not uncommon. Among them, skin rash is a major problem that plagues clinicians in making treatment decisions. The rash had to reduce the drug dose or even stop the drug. Therefore, it not only affects the quality of life of patients, but more seriously, it weakens the intensity of anti-tumor treatment, reduces the curative effect, shortens the survival period of patients, and even directly threatens the lives of patients due to serious infections. [0003] Antineoplastic drug-associated rash is a characteristic skin toxicity reaction, which usually occurs after 2-4 weeks of drug treatment. There are various types o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P17/00A61P35/00
CPCA61K9/0014A61K36/13A61K36/232A61K36/355A61K36/428A61K36/484A61K36/808A61K36/899A61K36/8994A61P17/00A61P35/00A61K2300/00
Inventor 舒琦瑾陈舒怡寿柳梅陈赐慧
Owner 浙江省中医院、浙江中医药大学附属第一医院
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