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Application of vaginal microorganism in recurrent abortion

A recurrent miscarriage and microbial technology, applied in the biological field, can solve problems such as the lack of effective prediction of URSA, and achieve the effect of improving the quality of life

Inactive Publication Date: 2020-10-02
成都锦江西囡诊所有限公司 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The recurrence risk of URSA increases with the increase of the number of miscarriages (Gynaecologists R C O O. The investigation and treatment of couples with recurrent first trimester and second-trimester miscarriage (Green-top Guideline No.17)[J].Royal College of Obstetricians and Gynaecologists,2011 .), which has a serious impact on the family and society, but there is currently no effective clinical indicator for predicting the occurrence of URSA

Method used

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  • Application of vaginal microorganism in recurrent abortion
  • Application of vaginal microorganism in recurrent abortion
  • Application of vaginal microorganism in recurrent abortion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Detection of microbial flora associated with unexplained recurrent miscarriage

[0036] 1. Collection of samples

[0037] 40 patients with unexplained recurrent abortion in early pregnancy were selected as the experimental group (URSA), and 45 cases of normal pregnant women during the same period were selected as the control group, and the latter were strictly matched. The vaginal secretions of the experimental group and the control group were collected.

[0038] Inclusion criteria: control group: had at least one normal pregnancy, and no history of spontaneous abortion; URSA group: had 2 or more spontaneous abortion history, meeting the diagnostic criteria for recurrent abortion.

[0039] Exclusion criteria: those with chromosomal abnormalities, abnormal uterine anatomical structure or routine abnormal semen of the man, history of taking teratogenic drugs in early pregnancy; history of gastrointestinal surgery, severe liver and kidney insufficiency, history ...

Embodiment 2

[0063] Example 2 The diagnostic efficacy of Rhodoluna

[0064]According to the relative content of Rhodoluna, the receiver operating characteristic curve (ROC) was drawn using SPSS, and the binomial exact confidence space was calculated to analyze the sensitivity and specificity of Rhodoluna for the diagnosis of recurrent miscarriage.

[0065] The ROC curve and characteristic parameters are as follows figure 2 As shown in Table 1, the area under the curve is 0.916, the threshold of the optimal critical point is 3.5, the sensitivity of this point is 0.975, and the specificity is 0.733, which has high sensitivity and specificity.

[0066] Table 1 area under the curve

[0067] Test outcome variable: Rhodoluna

[0068]

[0069] a. Under non-parametric assumptions

[0070] b. Null hypothesis: real area = 0.5

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Abstract

The invention discloses application of a vaginal microorganism in recurrent abortion. The microorganism is Rhodoluna. The microorganism marker has high sensitivity in predicting recurrent abortion, and can be used for warning a subject by detecting the abundance of the microorganism marker, and further reducing risks by adjusting diet or medical intervention.

Description

technical field [0001] The invention belongs to the field of biotechnology and relates to the application of vaginal microbes in recurrent abortion. Background technique [0002] Recurrent spontaneous abortion (RSA) is a complex disease that refers to two or more pregnancy failures occurring within 20 weeks (Kim J H, Jeon Y J, Lee B E, et al. Association of methionine synthase and thymidylate synthase genetic polymorphisms withidiopathic recurrent pregnancy loss[J]. Fertil Steril,2013,99(6):1674-1680.). The incidence rate in women of reproductive age is 1% to 5%, and the possibility of spontaneous abortion in RSA women is as high as 70% to 80% (Wu M, Liu P, Cheng L. Galectin-1 reduction and changes in T regulatory cells may playcrucial roles in patients with unexplained recurrent spontaneous abortion [J]. Int J Clin ExpPathol, 2015, 8(2): 1973-1978.). The etiology of RSA is complex and diverse. In addition to genetic factors, endocrine disorders, anatomical abnormalities, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/06G01N33/569A61K45/00A61P15/06A23L33/00C12R1/01
CPCA23V2002/00A61K45/00A23L33/00A61P15/06C12Q1/06G01N33/56911G01N2333/195G01N2469/10G01N2800/368G01N2800/50A23V2200/30
Inventor 郭燕华李平朱小凤
Owner 成都锦江西囡诊所有限公司
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