Application of Sanggenone G in preparation of drugs for treating psoriasis

A technology for psoriasis and mulberry ketone, which is applied in the field of mulberry ketone G in the preparation of medicines for treating psoriasis, can solve problems such as the chemical structure type and action target of psoriasis that have not yet been elucidated, and can reduce IL-17 and INF-γ levels, reducing the thickness of skin lesions, and improving the effect of disease

Inactive Publication Date: 2020-10-09
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are hundreds of chemical components in Cortex Morus alba, with complex and diverse structures. The chemical structure types and action targets of ...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Sanggenone G in preparation of drugs for treating psoriasis
  • Application of Sanggenone G in preparation of drugs for treating psoriasis
  • Application of Sanggenone G in preparation of drugs for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] Embodiment: the pharmacodynamic research of sangenone G treating psoriasis

[0032] 1. Purpose of the experiment

[0033] To investigate the effect of sanggenone G on imiquimod-induced mouse psoriasis model

[0034] 2. Experimental materials

[0035] 2.1 Animals: SPF grade BALB / c mice, female, weighing 200±20g, purchased from Changsha Tianqin Biotechnology Co., Ltd., license number: SCXK (Xiang) 2019-0014.

[0036] 2.2 Main instruments: analytical balance, electronic balance, 1mL syringe, gavage needle, animal cage, ultraviolet spectrophotometer, microplate reader, optical microscope, etc.

[0037]2.3 Main drugs and reagents: Sanggenone G, Sanggenone O (Chengdu Desite Biotechnology Co., Ltd., purity >98%), Imiquimod Cream (Sichuan Mingxin Pharmaceutical Co., Ltd.), methotrexate (Shanghai Xinyi Pharmaceutical Co., Ltd.), mouse IL-17 and mouse INF-γELISA kit (R&D Systems).

[0038] 3. Experimental method

[0039] 3.1 Establishment and administration of mouse psoriasi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an application of sanggenone G in preparation of a medicine for treating psoriasis. In the embodiment of the invention, the sanggenone G can remarkably improve the skin inflammatory response of an imiquimod-induced mouse psoriasis model animal, reduce the skin lesion degree, relieve the symptoms of erythema, scales, infiltration and the like of the skin, enable the epidermal layer to be complete and reduce the skin lesion thickness. The Sanggenone G can also significantly reduce the level of inflammatory factors IL-17 and INF-gamma related to psoriasis in splenic lymphocyte supernatant of model mice. Therefore, the Sanggenone G can effectively improve the condition of the psoriasis model mouse, has a prospect of being developed into the medicine for treating psoriasis, and has important social benefits and economic benefits.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of Sanggenone G, in particular to the application of Sanggenone G in the preparation of medicines for treating psoriasis. Background technique [0002] Psoriasis, commonly known as psoriasis, is a chronic, relapsing, inflammatory autoimmune skin disease mediated by T cells. The clinical manifestations are mainly red papules or plaques covered with multiple layers of white scales, mostly on the limbs, head and back. Severe skin lesions may spread to the skin of the whole body, with high fever, pustules, erythroderma-like changes and systemic lesions. Large and small joint disease. Psoriasis is affected by many factors such as age, gender, race, geographical location, environment, etc. The prevalence of different populations around the world varies greatly. For example, compared with Europe and the United States, psoriasis in China, Japan and other Asian countries relativel...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/352A61P17/06
CPCA61K31/352A61P17/06
Inventor 徐仁爱陈晶晶朱慧丹
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap