Preparation method of strontium/silver nano-coating modified bone bionic titanium implant

A bone biomimetic titanium and silver nanotechnology, applied in the field of preparation of bone biomimetic titanium implants, can solve the problems of biological toxicity limiting clinical application

Inactive Publication Date: 2020-10-27
温州医科大学附属口腔医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Silver has been proven to have the best antibacterial ability among metallic elements, however, its significant biotoxicity limits its clinical application

Method used

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  • Preparation method of strontium/silver nano-coating modified bone bionic titanium implant
  • Preparation method of strontium/silver nano-coating modified bone bionic titanium implant
  • Preparation method of strontium/silver nano-coating modified bone bionic titanium implant

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Experimental program
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Embodiment 1

[0039]Step 1: Preprocessing. The surface of the titanium material is ground and polished with 600-mesh, 800-mesh, 1500-mesh, and 2000-mesh sandpaper in sequence, and then ultrasonically cleaned with acetone, ethanol, and deionized water in turn, and dried;

[0040] Step 2: Alkali treatment. The titanium material treated in step 1 is placed in an alkaline solution with a temperature of 80° C. to react for 24 hours. After the reaction, the sample is taken out, then washed, dried, and stored in a vacuum to obtain a standby titanium material;

[0041] Step 3: Build the nano-silver coating. Using metallic silver as a target source, a nano-silver coating is constructed by sputtering on the surface of the standby titanium material by magnetron sputtering. First, pre-sputtering was performed with parameters set to pressure 1Pa, power 80W, temperature 23°C, time 5min; then working sputtering was performed, parameters were set to pressure 0.5Pa, power 80W, temperature 23°C, time 1min....

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Abstract

The invention discloses a preparation method of a strontium / silver nano-coating modified bone bionic titanium implant. The method comprises the following steps of carrying out modification and hot alkali treatment on the surface of a titanium material by a magnetron sputtering method, and sequentially coating the surface with a nano-sized two-layer film containing silver element and strontium element, thereby obtaining the bone bionic titanium implant with good biocompatibility, osteogenic induction promoting function and good antibacterial property. The magnetron sputtering method provided bythe invention has the advantages of simple process method, small matrix damage and the like.

Description

technical field [0001] The invention relates to the field of titanium material modification, in particular to the preparation of a strontium / silver nano-coating modified bone biomimetic titanium implant. Background technique [0002] Titanium is a silver-white transition metal characterized by light weight, high strength, metallic luster, and resistance to wet chlorine corrosion. Because of their excellent biocompatibility, chemical stability, mechanical properties and good osseointegration ability, titanium and titanium alloys are the most commonly used biomaterials for orthodontic implants, prosthetic implants and bone repair. It is the gold standard for implant restoration. [0003] However, the titanium implant itself has no antibacterial properties, and has certain sensitization, inflammatory and possible loosening and falling off, which limits its application in the biological field. In addition, patients with osteoporosis are often encountered in clinical applicatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/50A61L27/54C23C14/35C23C14/16C23C14/08C23C14/02
CPCA61L27/06A61L27/306A61L27/50A61L27/54C23C14/352C23C14/165C23C14/088C23C14/021A61L2300/104A61L2300/102A61L2300/404A61L2300/412A61L2300/61A61L2400/18A61L2420/08A61L2430/02
Inventor 王海燕屈海忠姚李韬胡荣党史春玲
Owner 温州医科大学附属口腔医院
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