High-throughput culture plate, high-throughput multi-organ co-culture chip and application of high-throughput multi-organ co-culture chip
A culture plate, multi-organ technology, applied in tissue cell/virus culture devices, biochemical instruments, bioreactor/fermenter combinations, etc., can solve problems such as difficulty in accurately predicting liver damage
Pending Publication Date: 2020-10-27
BEIJING DAXIANG BIOTECH CO LTD
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Problems solved by technology
In the process of drug development, it is difficult to accurately predict the liver damage of the research and development drug, and once this liver damage occurs, it is difficult to recover
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[0053] The technical solutions of the present disclosure will be clearly and completely described below in conjunction with the embodiments of the present disclosure. Apparently, the described embodiments are only some of the embodiments of the present disclosure, not all of them. Based on the embodiments in the present disclosure, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present disclosure.
[0054] The embodiment of the present disclosure discloses a suspended culture plate 10, combined with Figure 1 to Figure 5As shown, the suspended culture plate 10 includes a plate body, and a plurality of protrusions 11 are arranged on one side of the plate body, and a raised pattern 110 is formed on the end surface of each protrusion 11 .
[0055] In the suspended culture plate 10 of the embodiment of the present disclosure, the surface of the raised pattern 110 is hydrophobic, and the cell s...
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Abstract
The invention discloses a high-throughput culture plate, a high-throughput multi-organ co-culture chip and application of the high-throughput multi-organ co-culture chip, and belongs to the field of biological tissue engineering. A suspended culture plate is provided with a plurality of convex columns on one side face of a plate body, and a convex pattern is formed on the end face of each convex column. The culture chip comprises the plate body, wherein a plurality of culture holes and fluid operation channels are formed in the plate body, and the fluid operation channels are configured to becapable of carrying out operation on fluid in the culture holes through the fluid operation channels. The co-culture chip is arranged on the culture chip in a manner that the plurality of convex columns of the suspended culture plate are correspondingly suspended in the plurality of culture holes of the culture chip. The co-culture chip is applied to constructing a multi-organ co-culture model. Atleast two organ cells can be cultured at the same time, the multi-organ co-culture model is constructed, and a platform can be provided for large-scale metabolic drug screening and related mechanismresearch.
Description
technical field [0001] This application relates to the technical field of biological tissue engineering, such as high-throughput culture plates, high-throughput multi-organ co-culture chips and their applications. Background technique [0002] Organ chip technology is an emerging cutting-edge technology in the field of biotechnology, and was listed as one of the "Top Ten Emerging Technologies" by the World Economic Forum in Davos in 2016. It is a technology that utilizes micro-processing technology to construct organ physiological microsystems. It usually includes key elements of the organ microenvironment, such as living cells, tissue interfaces, biological fluids, and mechanical forces, and can reflect the main structural and functional characteristics of tissues and organs. . [0003] The liver is an organ in the body whose main function is metabolism, and it can completely decompose and biotransform drugs. The metabolism of drugs in the liver changes the chemical struc...
Claims
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IPC IPC(8): C12M3/00C12M1/00
CPCC12M21/08C12M23/12
Inventor 肖荣荣周宇
Owner BEIJING DAXIANG BIOTECH CO LTD