Eye drops for treating glaucoma and preparation method thereof
A technology for eye drops and glaucoma, which is applied in the field of medicine, can solve the problems of low solubility of tafluprost, poor water solubility and poor stability of tafluprost, and achieve the effects of reducing impurities, improving curative effect and improving stability
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[0026] Example 1
[0027] An eye drop for treating glaucoma, its formula is:
[0028] Tafluprost 0.0375g
[0029] Modified polylysine 1.05g
[0030] Citric acid 1.25g
[0031] Adjust the pH to 6.7 with 1000 mL of water for injection.
[0032] Preparation:
[0033] Step 1: At 10°C, weigh the amount of tafluprost, add water for injection, stir to form an emulsion, add modified polylysine, and stir to form nanomicelles;
[0034] Step 2: Dissolve stabilizer citric acid with water for injection at 10°C to obtain an aqueous solution of stabilizer citric acid;
[0035] Step 3: Mix the aqueous solution of stabilizer citric acid with the micelles obtained in Step 1, at 10°C, add water for injection, and stir to dissolve;
[0036] Step 4: Adjust the pH to 6.7, add sterile water for injection to 1000 mL, filter and fill, and sterilize at 125°C to obtain the finished product.
Example Embodiment
[0037] Example 2
[0038] An eye drop for the treatment of glaucoma, its formula is:
[0039] Tafluprost 0.040g
[0040] Modified polylysine 2.5g
[0041] Ascorbic acid 1.25g
[0042] 1000mL water for injection, adjust the pH to 6.7
[0043] Preparation:
[0044] Step 1: At 10°C, weigh the amount of tafluprost, add water for injection, stir to form an emulsion, add modified polylysine, and stir to form nanomicelles;
[0045] Step 2: Dissolve the stabilizer ascorbic acid with water for injection at 10°C to obtain an aqueous solution of the stabilizer;
[0046] Step 3: Mix the aqueous solution of the stabilizer with the micelle obtained in Step 1, at 10°C, add water for injection, and stir to dissolve;
[0047] Step 4: Adjust the pH to 6.7, add sterile water for injection to 1000 mL, filter and fill, and sterilize at 125°C to obtain the finished product.
Example Embodiment
[0048] Example 3
[0049] An eye drop for treating glaucoma, its formula is:
[0050] Tafluprost 0.0425g
[0051] Modified polylysine 2.75g
[0052] Erythorbic acid 1.25g
[0053] 1000mL water for injection, adjust the pH to 6.7
[0054] Preparation:
[0055] Step 1: Weigh the formulated amount of tafluprost at 10°C, add water for injection, stir to form an emulsion, add modified polylysine, and stir to form nanomicelles;
[0056] Step 2: Dissolve the stabilizer erythorbic acid with water for injection at 10°C to obtain an aqueous solution of the stabilizer erythorbic acid;
[0057] Step 3: Mix the aqueous solution of stabilizer erythorbic acid with the micelles obtained in step 1, at 10°C, add water for injection, and stir to dissolve;
[0058] Step 4: Adjust the pH to 6.7, add sterile water for injection to 1000 mL, filter and fill, and sterilize at 125°C to obtain the finished product.
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