Medical adhesive as well as preparation method and application thereof

An adhesive and solvent technology, applied in the field of dental adhesives and preparation thereof, can solve the problems of poor compatibility of cross-linked polyvinylpyrrolidone, insufficient performance of epoxy resin, and difficulty in removing the adhesive completely. Protection from loss, less impact change, less effect on tooth damage

Active Publication Date: 2020-11-03
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The bonding performance of the dental adhesive needs to be improved, and the adhesive is difficult to remove completely, and residues may be left on the teeth, so it is necessary to use a dental drill to remove the residues
This treatment can cause additional damage to the enamel
[0004] CN106726626A discloses a medical adhesive and its preparation method, the preparation raw materials of the medical adhesive include: epoxy resin, cross-linked polyvinylpyrrolidone, seaweed sodium phosphate, peach gum, gum arabic, SiO2, nano zirconia, nacre powder, zirconium silicate, titanium carbide, sodium monofluorophosphate, ultraviolet absorber UV-531, the medical adhesive The agent improves the mechanical strength of the binder by adding inorganic powders such as SiO2 and nano-zirconia, but the compatibility of the inorganic powder with epoxy resin and cross-linked polyvinylpyrrolidone is poor, so the ring The performance of oxygen resin and cross-linked polyvinylpyrrolidone cannot be fully exerted, so the invention adds more colloids to improve the adhesion, which will make it difficult to completely remove the adhesive and may leave residues on the teeth

Method used

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  • Medical adhesive as well as preparation method and application thereof
  • Medical adhesive as well as preparation method and application thereof
  • Medical adhesive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] This embodiment provides a kind of medical adhesive, and the preparation raw material of described medical adhesive comprises: 35% rosin resin (weight average molecular weight is 9000), 15% polyvinyl alcohol (weight average The molecular weight is 200,000), 15% hydroxymethyl cellulose, 8% sodium alginate, 7% zinc tripolyphosphate, 2% hydroxyapatite, 3% thermally expandable microspheres (acrylonitrile-formazol Methyl acrylate copolymer, the initial foaming temperature is 100 °C, the expansion ratio is 8 times, the initial particle size is 20 μm), and 15% palm oil.

[0048] The preparation method of medical adhesive described in the present embodiment comprises the following steps:

[0049] (1) Mix and stir rosin resin, polyvinyl alcohol and palm oil at 60° C. at a speed of 150 r / min for 10 minutes to obtain the first mixture;

[0050] (2) The first mixture obtained in step (1), hydroxymethyl cellulose, sodium alginate, zinc tripolyphosphate and hydroxyapatite were mixed...

Embodiment 2

[0053] This embodiment provides a kind of medical adhesive, and the preparation raw material of described medical adhesive comprises: 30% rosin resin (weight-average molecular weight is 9000), 20% polyvinyl alcohol (weight-average Molecular weight is 200,000), 10% hydroxyethyl cellulose, 10% sodium alginate, 10% sodium tripolyphosphate, 3% hydroxyapatite, 5% thermally expandable microspheres (acrylonitrile-formazol Methyl acrylate copolymer, the initial foaming temperature is 120°C, the expansion ratio is 10 times, and the initial particle size is 20 μm), 12% coconut oil.

[0054] The preparation method of medical adhesive described in the present embodiment comprises the following steps:

[0055] (1) Mix and stir rosin resin, polyvinyl alcohol and coconut oil at a speed of 100 r / min for 10 min at 70° C. to obtain the first mixture;

[0056] (2) Mix and stir the first mixture obtained in step (1), hydroxyethyl cellulose, sodium alginate, sodium tripolyphosphate and hydroxyapa...

Embodiment 3

[0059] This embodiment provides a kind of medical adhesive, and the preparation raw material of described medical adhesive comprises: 40% rosin resin (weight-average molecular weight is 9000), 10% polyvinyl alcohol (weight-average Molecular weight is 200,000), 20% hydroxypropyl methylcellulose, 5% sodium alginate, 5% zinc tripolyphosphate, 4% hydroxyapatite, 2% thermally expandable microspheres (acrylonitrile -Methyl methacrylate copolymer, the initial foaming temperature is 100°C, the expansion ratio is 8 times, the initial particle size is 20 μm), 14% coconut oil.

[0060] The preparation method of medical adhesive described in the present embodiment comprises the following steps:

[0061] (1) Mix and stir rosin resin, polyvinyl alcohol and coconut oil at a speed of 200 r / min for 10 min at 50° C. to obtain the first mixture;

[0062] (2) The first mixture obtained in step (1), hydroxypropyl methylcellulose, sodium alginate, zinc tripolyphosphate and hydroxyapatite were mixe...

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Abstract

The invention provides a medical adhesive as well as a preparation method and application thereof. The medical adhesive is prepared from the following raw materials: rosin resins, a hydrophilic glassypolymer, hydroxy cellulose, sodium alginate, polyphosphate, hydroxyapatite, thermal expansion microspheres and a solvent. The medical adhesive has the advantages of strong adhesion to dental materials, high adhesion strength, small influence change on cold and hot environments, realization of automatic shedding of the adhesive in an effective and comfortable manner through applying heat generatedby ultrasonic waves, being free from residual, and being free from damage to teeth.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a medical adhesive and its preparation method and application, in particular to a dental adhesive and its preparation method and application. Background technique [0002] In the field of dentistry, there are many tooth bonding techniques, such as filling of tooth defects, sealing of cracks, bonding of tooth brackets, etc., all need to use dental adhesives. Dental adhesives have more stringent requirements than ordinary adhesives because the bonding object is the living tissue of the tooth and is in the harsh oral environment. It requires that the adhesive has no harm to tooth tissue and oral mucosa, does not decompose under the action of bacteria and enzymes in saliva, does not age, and has strong adhesion to teeth, dental alloys, plastics, ceramics and other materials . Although through people's long-term efforts, there is no ideal binder so far. This is mainly because the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/898A61K6/884A61K6/838A61K6/889A61K6/864A61K6/887A61K6/30
CPCA61K6/898A61K6/884A61K6/838A61K6/889A61K6/864A61K6/887A61K6/30C08L1/284C08L5/04C08L29/04C08L39/06C08L33/12
Inventor 徐迹黄国栋张晓洁陈凡帆徐勇刘文兰
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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