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Composite nanoparticles for targeted inhibition of bone tumors and preparation method of composite nanoparticles

A composite nanoparticle, nanoparticle technology, applied in antitumor drugs, bone diseases, drug combinations, etc., can solve problems such as body damage and achieve the effect of repairing bone

Inactive Publication Date: 2020-11-03
吴宏伟 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, simply injecting nano-hydroxyapatite into the body is harmful to the body

Method used

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  • Composite nanoparticles for targeted inhibition of bone tumors and preparation method of composite nanoparticles
  • Composite nanoparticles for targeted inhibition of bone tumors and preparation method of composite nanoparticles
  • Composite nanoparticles for targeted inhibition of bone tumors and preparation method of composite nanoparticles

Examples

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Effect test

Embodiment 1

[0043] The composite nanoparticles for targeting and inhibiting bone tumors include the following components in terms of mass fraction:

[0044] 3 parts of hyaluronic acid, 25 parts of tetrabutylammonium hydroxide aqueous solution, 3 parts of polyethylene glycol, 0.8 parts of dimethylaminopyridine, 3 parts of nano-hydroxyapatite, 3 parts of nitrogen carbonyl diimidazole, anhydrous dimethyl 180 parts of sulfone; the concentration of the tetrabutylammonium hydroxide aqueous solution is 40%.

Embodiment 2

[0046] The composite nanoparticles for targeting and inhibiting bone tumors include the following components in terms of mass fraction:

[0047] 4 parts of hyaluronic acid HA, 30 parts of tetrabutylammonium hydroxide aqueous solution, 4 parts of polyethylene glycol, 1 part of dimethylaminopyridine, 4 parts of nano-hydroxyapatite, 4 parts of nitrogen carbonyl diimidazole, anhydrous dimethyl Sulfone 210 parts.

Embodiment 3

[0049] The composite nanoparticles for targeting and inhibiting bone tumors include the following components in terms of mass fraction:

[0050] 5 parts of hyaluronic acid, 35 parts of tetrabutylammonium hydroxide aqueous solution, 5 parts of polyethylene glycol, 1.2 parts of dimethylaminopyridine, 5 parts of nano-hydroxyapatite, 5 parts of nitrogen carbonyl diimidazole, anhydrous dimethyl 240 parts of sulfone; the concentration of the tetrabutylammonium hydroxide aqueous solution is 40%.

[0051] The present invention provides a method for preparing composite nanoparticles targeted to inhibit bone tumors. The specific components are described in Example 2, such as figure 1 shown, including the following steps:

[0052] Step 100, preparing HA-TBA mixed product

[0053] Take 0.4g of hyaluronic acid (HA) and 3mL of 40% tetrabutylammonium hydroxide aqueous solution (TBA), mix and stir to dissolve, stir at room temperature for 30min, take Millex-HV 450nm sterile filter head to f...

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Abstract

The embodiment of the invention discloses composite nanoparticles for targeted inhibition of bone tumors. The composite nanoparticles comprise the following components in parts by weight: 3-5 parts ofhyaluronic acid, 25-35 parts of a tetrabutylammonium hydroxide aqueous solution, 3-5 parts of polyethylene glycol, 0.8-1.2 parts of dimethylaminopyridine, 3-5 parts of nano hydroxyapatite, 3-5 partsof nitrogen-nitrogen carbonyl diimidazole and 180-240 parts of anhydrous dimethyl sulfoxide. A preparation method of the composite nanoparticles comprises the following steps of sequentially preparingan HA-TBA mixed product, a PEG-HA compound, PEG-HA-HAP nanoparticles and zoledronic acid-loaded PEGHAHAP / Zol nanoparticles. According to the invention, the nano-hydroxyapatite is made into a targeting preparation to exert the effect of inhibiting bone tumors, can be locally administrated to inhibit tumors and bone destruction, can also be wholly administrated to target and gather at the bone tumor part to promote bone repair, and is a potential novel nano-targeting preparation capable of resisting tumors and repairing bone substances.

Description

technical field [0001] The embodiments of the present invention relate to the technical field of nanoparticle preparation, in particular to a composite nanoparticle for targeting and inhibiting bone tumors and a preparation method thereof. Background technique [0002] At present, there are still many challenges in the clinical treatment of primary and metastatic bone tumors. Osteosarcoma and bone metastases usually require chemotherapy or targeted drug therapy to kill tumor cells and reduce tumor-induced bone destruction. Whether these drugs are systemic or local, they need to be targeted to the tumor site as much as possible to increase the tumor killing effect and reduce systemic side effects. [0003] Zoledronic acid is a common drug that inhibits osteoclasts, and has obvious therapeutic effects on the treatment of giant cell tumor of bone, osteoporosis, and osteolytic bone destruction of malignant bone tumors. However, systemic administration of zoledronic acid can pro...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K31/675A61K9/19A61K47/60A61K47/61A61P35/00A61P19/10A61P19/08
CPCA61K33/42A61K31/675A61K9/19A61K47/60A61K47/61A61P35/00A61P19/10A61P19/08
Inventor 吴宏伟钟午许彦黄钢黄少兵
Owner 吴宏伟
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