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Flexible film-like material for SERS detection and preparation method of flexible film-like material

A technology for detecting flexible and flexible films, which is applied in the fields of analyzing materials, material excitation analysis, and material analysis by optical means. Uniform thickness, easy to wipe sampling effect

Active Publication Date: 2020-11-10
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent No. CN110132940A specifically discloses an arrayed flexible SERS substrate and its preparation method, in which silver nanoparticles are directly added dropwise to the detection area, which is likely to cause uneven distribution. On the other hand, the stability of metallic silver is weaker than that of metallic gold, so It needs to be protected from light during the preparation process

Method used

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  • Flexible film-like material for SERS detection and preparation method of flexible film-like material
  • Flexible film-like material for SERS detection and preparation method of flexible film-like material
  • Flexible film-like material for SERS detection and preparation method of flexible film-like material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 (see figure 1 )

[0030] 1) Preparation of PCL / CS composite solution: Dissolve 0.8g of PCL particles in 9.2g of glacial acetic acid solution at 50°C to obtain 8%wt PCL solution; dissolve 0.2g of CS powder in 9.8g of 90%wt acetic acid at 90°C solution, a 2% wt CS solution was obtained. At 50°C, 3.33g 8%wt PCL was added dropwise to 10g 2%wt CS with a mass ratio of 1:1.5, and stirred at 50°C for 2h to synthesize a PCL / CS solution.

[0031] 2) Preparation of PCL / CS flexible film: inject the PCL / CS solution into the mold, dry it at 50°C to form a film, soak it in 10% NaOH for 5 minutes, rinse and soak it with clean water until the solution is neutral. Finally, dry again in a natural state for later use.

[0032] 3) Preparation of gold seed solution: 0.025mL 0.01M HAuCl 4 solution and 0.6 mL of 0.01M NaBH 4 The solution was added to 1 mL of 0.1M CTAB solution, stirred for 30 min, and left to stand for use.

[0033] 4) Immerse the PCL / CS flexible film cut in...

Embodiment 2

[0037]1) Preparation of PCL / CS composite solution: Dissolve 0.8g of PCL particles in 9.2g of glacial acetic acid solution at 50°C to obtain 8%wt PCL solution; dissolve 0.2g of CS powder in 9.8g of 90%wt acetic acid at 90°C solution, a 2% wt CS solution was obtained. At 50°C, 3.33g 8%wt PCL was added dropwise to 10g 2%wt CS with a mass ratio of 1:1.5, and stirred at 50°C for 2h to synthesize a PCL / CS solution.

[0038] 2) Preparation of PCL / CS flexible film: inject the PCL / CS solution into the mold, dry it at 50°C to form a film, soak it in 10% NaOH for 5 minutes, rinse and soak it with clean water until the solution is neutral. Finally, it was dried again in a natural state for further use, and its morphology was characterized by SEM.

[0039] 3) Preparation of gold seed solution: 0.025mL 0.01M HAuCl 4 solution and 0.6 mL of 0.01M NaBH 4 The solution was added to 1 mL of 0.1M CTAB solution, stirred for 30 min, and left to stand for use.

[0040] 4) Immerse the PCL / CS flexi...

Embodiment 3

[0044] 1) Preparation of PCL / CS composite solution: Dissolve 0.8g of PCL particles in 9.2g of glacial acetic acid solution at 50°C to obtain 8%wt PCL solution; dissolve 0.2g of CS powder in 9.8g of 90%wt acetic acid at 90°C solution, a 2% wt CS solution was obtained. At 50°C, 3.33g 8%wt PCL was added dropwise to 10g 2%wt CS with a mass ratio of 1:1.5, and stirred at 50°C for 2h to synthesize a PCL / CS solution.

[0045] 2) Preparation of PCL / CS flexible film: inject the PCL / CS solution into the mold, dry it at 50°C to form a film, soak it in 10% NaOH for 5 minutes, rinse and soak it with clean water until the solution is neutral. Finally, dry again in a natural state for later use.

[0046] 3) Preparation of gold seed solution: 0.025mL 0.01M HAuCl 4 solution and 0.6 mL of 0.01M NaBH 4 The solution was added to 1 mL of 0.1M CTAB solution, stirred for 30 min, and left to stand for use.

[0047] 4) Immerse the PCL / CS flexible film cut into a suitable size into the gold nanopar...

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PUM

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Abstract

The invention discloses a flexible membranous material for SERS (Surface Enhanced Raman Scattering) detection and a preparation method of the flexible membranous material, and is characterized in thatthe material consists of two parts, namely gold nanoparticles and a polycaprolactone (PCL) / chitosan (CS) composite polymeric membrane, wherein the hydrophobicity of PCL and hydrophilia of chitosan allow the material to have both hydrophobicity and hydrophilia. and the gold nanoparticles have a surface Raman enhancement effect. The preparation method comprises the following steps: 1, preparing thePCL / CS composite film; 2, growing the gold nanoparticles on the composite membrane in situ, so that the surface Raman enhancement effect can be achieved, and the uniformity and reproducibility of SERS signals can be enhanced;.

Description

technical field [0001] The invention relates to a flexible film material for SERS detection and a preparation method thereof, belonging to the technical field of surface-enhanced Raman analysis and detection. Background technique [0002] Polycaprolactone (PCL) is a linear aliphatic polyester synthetic polymer, and its molecular chain has good flexibility, so that it has excellent mechanical properties. In addition, polycaprolactone has biocompatibility, biodegradability, good flexibility and fibrilability, and is widely used in drug carriers, plasticizers, and degradable plastics, but the disadvantage of poor hydrophilicity makes it Application is limited. [0003] Chitosan (CS) is a derivative of natural biological macromolecule chitin obtained by deacetylation, with active hydroxyl and amino groups for chemical reaction and salt formation. As a marine biomass material, chitosan is rich in sources and has many excellent properties, such as moisture absorption, reactivity...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L5/08C08J7/06C08J5/18G01N21/65
CPCC08J7/06C08J5/18G01N21/658C08J2367/04C08J2405/08
Inventor 范敏卢玉栋陈彩柔姚天博游瑞云李爱民
Owner FUJIAN NORMAL UNIV
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