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Pharmaceutical composition for treating radioactive oral mucositis and preparation method thereof

A technology of oral mucositis and composition, applied in the field of medicine, can solve problems such as heavy odor, inconvenient preparation, unacceptable to patients, etc.

Active Publication Date: 2020-11-13
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine preparations are considered to reduce the severity of radiation-induced oral mucositis and relieve pain. However, traditional Chinese medicine preparations are mainly decocted decoctions, which are inconvenient to prepare and have a strong smell. Patients are difficult to accept

Method used

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  • Pharmaceutical composition for treating radioactive oral mucositis and preparation method thereof
  • Pharmaceutical composition for treating radioactive oral mucositis and preparation method thereof
  • Pharmaceutical composition for treating radioactive oral mucositis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A pharmaceutical composition for treating radiation-induced oral mucositis, the contents of raw materials and auxiliary materials are shown in Table 1.

[0048] Table 1 Embodiment 1 raw material content list

[0049]

[0050]

[0051] In this embodiment, each raw material is in the form of decoction pieces, and each 1 g of particles is equivalent to 2.85 g of decoction pieces. Decoction pieces are traditional Chinese medicines that are processed and processed according to needs and are used for formulating. The decoction pieces of each raw material in this example are obtained after conventional processing.

[0052] The preparation method of the pharmaceutical composition for the treatment of radiation oral mucositis of the present embodiment comprises the following steps:

[0053] 1. Extraction (water extraction), concentration

[0054] 1.1 Put the weighed mint decoction pieces into the extraction device, add 6 times the amount of water, keep warm for 1 hour fo...

Embodiment 2

[0064] A pharmaceutical composition for treating radiation-induced oral mucositis, the content of its raw materials and auxiliary materials is shown in Table 2.

[0065] Table 2 Embodiment 2 raw material content list

[0066] name Dosage / g Agrimony Pieces 354 North Sha Ginseng Decoction Slices 354 Ophiopogon japonicus slices 354 Astragalus Pieces 354 Honeysuckle Pieces 354 Rush Pieces 35.4 magnolia flower drink 143 Licorice Pieces 71 mint slices 71 beta cyclodextrin 205 Maltodextrin 230 Carboxymethyl Starch Sodium 30 Povidone K30 20

[0067] In this embodiment, each raw material is in the form of decoction pieces, and each 1 g of particles is equivalent to 2.85 g of decoction pieces. Decoction pieces are traditional Chinese medicines prepared by processing according to the needs for formulating. The decoction pieces of each raw material in this example are obtained after conventional ...

Embodiment 3

[0070] A pharmaceutical composition for treating radiation-induced oral mucositis, the contents of its raw materials and auxiliary materials are shown in Table 3.

[0071] Table 3 Embodiment 3 raw material content list

[0072]

[0073]

[0074] In this embodiment, each raw material is in the form of decoction pieces, and each 1 g of particles is equivalent to 2.85 g of decoction pieces. Decoction pieces are traditional Chinese medicines prepared by processing according to the needs for formulating. The decoction pieces of each raw material in this example are obtained after conventional processing.

[0075] The preparation method of the pharmaceutical composition for treating radiation-induced oral mucositis in this example is consistent with Example 1.

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Abstract

The invention relates to the field of medicine, in particular to a pharmaceutical composition for treating radioactive oral mucositis and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 15-40 parts of hairyvein agrimony, 15-40 parts of radix glehniae, 15-40 parts of radix ophiopogonis, 15-40 parts of astragalus membranaceus, 15-40 parts of honeysuckle, 1-8 parts of juncus effuses, 5-20 parts of flos magnoliae liliflorae, 3-10 parts of raw liquorice and 3-10 parts of mint. According to the invention, the traditional Chinese medicines such as agrimonia pilosa ledeb, adenophora stricta and the like are reasonably matched by adopting a method for qi tonifying, yin nourishing, stasis removing and detoxifying, and aretaken by adopting a specific compound granule process and a buccal administration method, so that the severity of radioactive oral mucositis can be reduced, pain can be relieved, the radiotherapy intake of a patient can be improved, and the treatment compliance can be improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition for treating radiation-induced oral mucositis and a preparation method thereof. Background technique [0002] Radiotherapy is currently one of the most effective methods for treating malignant tumors. It can kill tumor cells very well, and at the same time has a killing effect on normal human tissue cells. Radiation oral mucositis (radiotherapy-induced oral mucositis, RTOM) is common in head and neck tumors, especially nasopharyngeal carcinoma, with an incidence rate of 50% to 100%, which is related to the radiation dose and fractionation method of radiation therapy; it is also associated with combined use The type and dose of chemotherapy drugs are related to chemotherapy. Moderate to severe radiation-induced oral mucositis causes pain in the mouth of patients, affects eating, increases the risk of malnutrition and treatment interruption, prolongs hospital s...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/16A61K47/69A61P1/02A61P39/00
CPCA61K9/0056A61K9/1652A61K36/23A61K36/355A61K36/481A61K36/484A61K36/534A61K36/575A61K36/73A61K36/88A61K36/8968A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K47/6951A61P1/02A61P39/00A61K2300/00
Inventor 蒋梅林丽珠徐剑锟张琦璐张晶
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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