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Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health products for preventing and treating acute liver injury

A technology for acute liver injury and extract, applied in the field of medicine, can solve problems such as no literature reports in research, and achieve the effects of high safety and simple extraction process

Pending Publication Date: 2020-11-17
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no literature reports on the prevention and treatment of acute liver injury by Quezui tea extract at home and abroad

Method used

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  • Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health products for preventing and treating acute liver injury
  • Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health products for preventing and treating acute liver injury
  • Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health products for preventing and treating acute liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of sparrow beak tea extract

[0023] Quezui tea was collected from Wuding, Yunnan, dried naturally and then powdered to obtain a sample of Quezui tea; weigh 100g of Quezui tea sample, and use 70% volume concentration of Ultrasonic-assisted extraction of methanol aqueous solution at 25°C for 30 minutes, filtration, and repeated extraction of the filter residue twice, combined filtrates, concentration and freeze-drying to obtain Quezui tea extract.

Embodiment 2

[0024] Example 2: Applying the method of paracetamol (APAP) induction to establish an aging model, and observing the effect of bird's mouth tea extract on preventing acute liver injury in mice through animal model experiments

[0025] 1. Establishment of acute liver injury model and experimental process

[0026] Taking Kunming male mice (weight 18-22g) as the research object, 8 mice in each group; after 7 days of acute modeling, the effect of Quezui tea extract on APAP-induced acute liver injury was evaluated by gavage. Preventive or delaying effect of mice; after purchasing, the mice were adapted to the standard environment for seven days, and the mice were fed according to the conventional feeding method. The specific experimental process and grouping were as follows:

[0027] Negative control group: intragastric administration for 7 days, and 5 mL / kg normal saline (0.9%) every day;

[0028] Model group (APAP group): intragastric administration of normal saline for 7 days, ...

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Abstract

The invention discloses novel application of vaccinium dunalianum wight or an extract thereof, namely application of vaccinium dunalianum wight or an extract thereof in preparation of medicines or health care products for preventing and / or treating acute liver injury, and belongs to the technical field of natural medicine development or medicine. According to the application, experimental resultsshow that the vaccinium dunalianum wight has a remarkable effect of preventing and treating acute liver injury; and the vaccinium dunalianum wight is a natural product, high in safety, simple in extraction process and suitable for industrial production and market popularization and application, and a new application way is provided for development and utilization of the vaccinium dunalianum wight.

Description

technical field [0001] The invention relates to the use of sparrow mouth tea or its extract in the preparation of medicines or health care products for preventing and / or treating acute liver injury, and belongs to the technical field of medicine. Background technique [0002] There are various types of liver disease, ranging from mild hepatocellular injury and necrosis to cirrhosis and liver cancer. Excessive alcohol consumption, liver viruses, various toxins and drugs are closely related to acute or chronic inflammation of the liver. Acute liver injury (Acute liver injury, ALI) is a disease that seriously affects human health. The etiology mainly includes: viral infection, autoimmune hepatitis, drugs, alcoholism and chemical poisons. In recent years, due to more and more common drug abuse, the metabolism of the liver has been seriously compromised, leading to a rapid increase in the incidence of drug-induced liver injury (DILI). Acute drug-induced liver injury (drug induc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/45A61P1/16A23L33/105
CPCA61K36/45A61P1/16A23L33/105A61K2236/333A61K2236/39A23V2002/00A23V2200/32A23V2300/14A23V2300/10A23V2300/20A23V2250/214
Inventor 程桂广张静王永朋李梦成邓晓翠赵天瑞曹建新刘亚平
Owner KUNMING UNIV OF SCI & TECH
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