Composition with whitening and spot-fading effects, cosmetic and preparation method thereof

A technology of composition and cosmetics, applied in the direction of cosmetic preparations, medical preparations containing active ingredients, cosmetics, etc., can solve the problems of easy oxidation and discoloration, yellowing of whitening products, weakening of skin barrier, etc., and achieve non-sensitization , prevent melanin production, inhibit the formation of spots

Pending Publication Date: 2020-11-20
铭颜生物科技(广州)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kojic acid will weaken the skin barrier, and is less stable to light, easy to oxidize and change color, which will make whitening products turn yellow during use

Method used

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  • Composition with whitening and spot-fading effects, cosmetic and preparation method thereof
  • Composition with whitening and spot-fading effects, cosmetic and preparation method thereof
  • Composition with whitening and spot-fading effects, cosmetic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0134] The preparation of the vitamin C polypeptide of the present invention: in a suitable stainless steel fermenter, the temperature is raised to 37 to 40 ° C, and the freshly collected citrus is chopped finely, and then, the citrus conjugated with ascorbic acid is used Carry out the synthetic ascorbic acid reaction with bioflavonoids, until the free ascorbic acid is no longer detected in the reaction tank, the reaction can be stopped, and usually the reaction needs to be carried out for 4 to 6 hours. Then, after the remaining solids are filtered, the remaining slurry is cleaned. At this time, the cleaning solution already contains the initial extraction components, and then the cleaning solution is made into a concentrated solution by vacuuming or under the protection of nitrogen. Finally, the The concentrated solution is spray-dried to a free-flowing white or cream-colored powder, namely Devitamin C Peptide. Vitamin C peptide is a stable and non-discoloring vitamin C deriv...

experiment example 1

[0137] Experimental example 1 Determination of the whitening and lightening effect of nicotinamide

[0138] 1. Determination of nicotinamide inhibition of melanin

[0139] Blank control group: joint culture system of keratinocytes and melanocytes;

[0140] Experimental group 1: Add nicotinamide (1mmol / L) to the joint culture system of keratinocytes and melanocytes (melanocyte strain 560);

[0141] Experimental group 2: Niacinamide (1mmol / L) was added to the joint culture system of keratinocytes and melanocytes (melanocyte strain: 660).

[0142] Using fluorescence to label the above three cell co-culture systems, the results of nicotinamide inhibiting the transfer rate of melanin are as follows: figure 1 As shown, niacinamide inhibits melanin migration by up to 68%.

[0143] 2. Determination of nicotinamide reducing pigmentation

[0144] Blank group: do not use skin care products;

[0145] PTU group: add fully controlled amount of PTU in daily skin care products;

[0146] P...

experiment example 2

[0150] Experimental example 2 Determination of the whitening and lightening efficacy of grape enzyme-glutathione

[0151] 1. Determination of grape enzyme-glutathione inhibition of tyrosinase

[0152] The results of the activity inhibition experiment of grape enzyme-glutathione on tyrosinase are as follows: Figure 4 It has been shown that grape enzyme-glutathione has an inhibitory effect on the activity of tyrosinase and can promote metabolism.

[0153] 2. Determination of pigmentation by grape enzyme-glutathione

[0154] Test sample: 100% grape enzyme-glutathione;

[0155] Reference sample: 30% 1,3-butanediol.

[0156] Detection method: Use the test sample on 6 volunteers for 7 days, twice a day.

[0157] Test results such as Figure 5 and Image 6 As shown, among them, ○pigmentation is lower than the reference; △pigmentation is the same as the reference; ×pigmentation is higher than the reference. After 7 days, the pigmentation effect of most people using grape enzym...

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Abstract

The invention discloses a composition with whitening and spot fading effects, cosmetic and a preparation method thereof. The composition is mainly prepared from, by weight, 2-8 parts of nicotinamide,1-5 parts of glutathione, 1-5 parts of alpha-arbutin, 1-5 parts of phenethyl resorcinol, 1-5 parts of vitamin C polypeptide and 1-5 parts of Kalanchoe pinnata leaf extract. The composition and the cosmetic thereof can prevent melanin from gathering and transferring, and reduce and decolorize melanin; the activity of tyrosinase is inhibited, and oxygen free radicals are removed to change the melanin generation path; therefore, melanin generation is prevented, and whitening and spot fading effects are further achieved.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a composition with the effect of whitening and lightening spots, cosmetics and a preparation method thereof. Background technique [0002] The production of melanin is related to internal organ dysfunction, endocrine disorder, ultraviolet radiation, high mental stress, skin trauma, poor diet, and use of inferior cosmetics. Diseases caused by melanin such as freckles, chloasma, melanosis, etc. , causing a lot of trouble to modern people, has always been the main content of research in the beauty and skin care industry. [0003] At present, there are many compounds used for whitening, brightening and removing spots, such as vitamin C, β-arbutin, kojic acid, etc., but the stability and safety of many raw materials with whitening effect are not very good. For example, vitamin C is easily damaged by light and decomposed, not stable enough, and easily oxidized. β-Arbutin has strict...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/67A61K8/64A61K8/34A61K8/60A61Q19/00A61Q19/02
CPCA61K8/9789A61K8/676A61K8/675A61K8/64A61K8/602A61K8/347A61Q19/00A61Q19/02A61K2800/782
Inventor 胡明华芦赟贺美丽邓劲松黎英强
Owner 铭颜生物科技(广州)有限公司
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