Dynamic control of accumulation time for chromatography mass spectrometry
A mass spectrometry and mass analysis technology, applied in the field of mass spectrometry, which can solve the problems of long accumulation duration and so on
Active Publication Date: 2020-11-24
THERMO FISHER SCI BREMEN
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Problems solved by technology
Therefore, at a relatively low rate of ions supplied to the ion trapping device, the accumulation duration for the ion trapping device to reach the desired ion count may be relatively long
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[0048] Herein, the term mass may be used to refer to the mass-to-charge ratio m / z.
[0049] figure 1 A schematic arrangement of a mass spectrometer 10 suitable for carrying out methods according to embodiments of the invention is shown. figure 1 The arrangement of shows schematically from Thermo Fisher Scientific, Inc. Configuration of the mass spectrometer.
[0050] exist figure 1 In , the sample to be analyzed (e.g. from an autosampler) is supplied to a chromatographic device, such as a liquid chromatography (LC) column ( figure 1 not shown). One such example of an LC column is the Thermo Fisher Scientific, Inc ProSwift monolithic column, which provides high performance liquid chromatography by forcing a sample carried in a mobile phase under high pressure through a stationary phase of irregular or spherical particles making up the stationary phase ( HPLC). In an HPLC column, sample molecules elute at different rates depending on how well they interact with the statio...
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A mass spectrometry method is provided. The method comprises eluting a sample from a chromatography system, and calculating a desired maximum scan duration for the sample eluting from the chromatographic system based on a duration of a chromatographic peak of the sample as it elutes from the chromatography system, and a minimum number of scans per chromatographic peak to be performed. A maximum accumulation duration is calculated based on the desired maximum scan duration. The sample is ionised to produce sample ions using an ion source. The sample ions are directed along an ion path from theion source to a mass analyser. A first set of mass analysis scans are performed. Each of the first set of mass analysis scans comprises: accumulating a portion of sample ions at a point along the ionpath, wherein the portion of sample ions are accumulated for a duration not exceeding the maximum accumulation duration, and mass analysing the portion of sample ions using the mass analyser. The massanalyser is a Fourier Transform mass analyser or a Time of Flight mass analyser.
Description
technical field [0001] The present disclosure relates to mass spectrometry. In particular, the present disclosure relates to methods and systems for mass spectrometry, including Fourier transform mass spectrometers or time-of-flight mass spectrometers. Background technique [0002] To analyze a sample of ions, some mass analyzers can employ amperometric detection of ions. Specifically, some mass analyzers can employ Fourier transforms of detected image currents to determine the frequency and / or mass of ions. Such mass analyzers are often referred to as Fourier transform mass analyzers. Fourier transform mass analyzers typically include an ion trapping device for trapping ion packets as part of mass analysis. It may be necessary to control the number of ions within the ion trapping device to limit space charge effects [0003] To analyze ions, some mass analyzers measure the time-of-flight of a sample of ions. Such mass analyzers are often referred to as time-of-flight (...
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IPC IPC(8): G01N30/02G01N30/72G01N30/86
CPCG01N30/02G01N30/72G01N30/86G01N30/7233H01J49/0031H01J49/40H01J49/425G01N30/8679H01J49/004H01J49/4265
Inventor C·托因格M·穆勒S·爱留克
Owner THERMO FISHER SCI BREMEN