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A localized surface plasmon resonance biochip, its manufacturing method, its biosensing system and its application

A technology of plasma and biochip, applied in the field of biosensing, can solve the problems of inability to meet high-throughput rapid detection of biological samples, insufficient number of detection channels of SPR system, small image and high fidelity, etc., to meet the requirements of Qualcomm Quantitative rapid detection, suitable for large-scale applications, and the effect of improving parallel processing capabilities

Active Publication Date: 2021-09-07
RAFAEL BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Adjusting the angle of incidence above 70 degrees using an ATR configuration results in a reflected image that is too small to be in focus with high fidelity, so the area that can only be used for multiplexing is very limited
The insufficient number of detection channels of the SPR system has greatly limited the parallel processing capacity and cannot meet the needs of high-throughput rapid detection of biological samples.

Method used

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  • A localized surface plasmon resonance biochip, its manufacturing method, its biosensing system and its application
  • A localized surface plasmon resonance biochip, its manufacturing method, its biosensing system and its application
  • A localized surface plasmon resonance biochip, its manufacturing method, its biosensing system and its application

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Embodiment Construction

[0045] As required, detailed embodiments of the present invention are disclosed herein. However, it should be appreciated by those skilled in the art that the detailed embodiments disclosed are merely exemplary of the invention, which may be embodied in various suitable forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but rather as a basis for the claims and as a means for teaching one skilled in the art to variously implement the invention in any suitable arrangement, structure or system. The basics.

[0046] refer to figure 1 , shows the structure of a gold-based SPR biochip in the prior art, in which a thick gold film is deposited on a substrate. The chip structure arrangement in the prior art needs to use more gold materials, and the manufacturing cost is high, which hinders the wide application of gold-based SPR biochips.

[0047] Figure 2 to Figure 9 The structure of the biochip of the present inven...

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Abstract

The invention discloses a localized surface plasmon resonance biochip, which comprises: (1) a substrate; (2) a plurality of optical waveguides arranged in the middle of the substrate, and the plurality of optical waveguides form an optical waveguide array ; (3) titanium nitride nanocubes disposed on the side surfaces of each of the optical waveguides; (4) a plurality of microfluidic channels disposed in the substrate. In addition, a method for manufacturing the above-mentioned biochip, a biosensing system including the above-mentioned biochip and applications thereof are also provided. The biological chip of the invention can not only reduce the manufacturing cost, improve the detection accuracy, but also meet the requirements of high-throughput rapid detection.

Description

technical field [0001] The invention relates to the field of biosensing, in particular to the fields of a localized surface plasmon resonance biochip, a manufacturing method thereof, a biosensing system containing the same, and applications thereof. Background technique [0002] An advanced version based on nanotechnology called localized surface plasmon resonance (LSPR) with nanostructures is a technology based on plasmon resonance (SPR) for label-free biosensing. Most of the existing SPR biosensors are based on silver, gold or silver-gold alloy as the plasmonic support material to excite the collective oscillation of the electron cloud. Gold is generally chemically inert and is the material of choice for established functionalization schemes. However, there are two disadvantages of gold as a plasmonic support material, (i) the gold material itself is expensive; and (ii) the thickness of the gold film is as high as about 50 nm, and the manufacturing cost of gold-based reso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/41G01N21/552G02B6/122
CPCG01N21/41G01N21/55G02B6/1226G02B6/1228
Inventor 吴兆鹏
Owner RAFAEL BIOTECHNOLOGY CO LTD
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