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Preparation method of poly-L-lactic acid tissue filling agent

A poly-L-lactic acid and filler technology, which is applied in the fields of beauty and medical treatment, can solve the problems of small size, inability to achieve filling effect, low accumulation concentration of lactic acid, etc., and achieve high production efficiency, easy transportation and storage, and simple and convenient process route Effect

Inactive Publication Date: 2020-12-11
吉林省杭盖秱博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Small size, low concentration of lactic acid accumulation, can not play a filling effect

Method used

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  • Preparation method of poly-L-lactic acid tissue filling agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation of poly-L-lactic acid tissue filler, specifically comprising the following steps:

[0039] Step 1: Bulk polymerization: Put 1kg of L-lactide and 0.3g of stannous octoate into the reactor, repeat 3 times of vacuuming to -0.095MPa, and fill with protective gas, so that the reactor is a protective gas atmosphere and then evacuated Vacuum to -0.1MPa, seal; heat the reactor to 125°C and react for 8h;

[0040] Step 2: Dispersion: Add 3000ml of dichloromethane to the reactor in Step 1, and stir and dissolve for 10 hours to obtain a solution;

[0041] Step 3: Purification: Slowly add the solution in step 2 to diethyl ether dropwise under stirring at a rate of 1-3 L / min. After adding all the solution, continue stirring for 0.5 hours to obtain a solid dispersion suspension.

[0042] Step 4: Suction filtration: Suction filtration of the solid dispersion suspension obtained in Step 3 to obtain a filter cake.

[0043] Step 5: Drying: vacuum-dry the filter cake obtain...

Embodiment 2

[0051] A preparation of poly-L-lactic acid tissue filler, specifically comprising the following steps:

[0052] Step 1: Bulk polymerization: Put 1kg of L-lactide and 0.5g of creatinine into the reactor, repeat 3 times of vacuuming to -0.095MPa, and fill in the protective gas, so that the reactor is in a protective gas atmosphere and then evacuated to -0.095MPa -0.1MPa, sealed; heat the reactor to 120°C and react for 10h;

[0053] Step 2: Dispersion: Add 4000 ml of chloroform to the reactor in step 1, and stir and dissolve for 12 hours to obtain a solution;

[0054] Step 3: Purification: Slowly add the solution in Step 2 to ethanol dropwise at a rate of 1-3 L / min under stirring. After adding all the solution, continue stirring for 0.5 hours to obtain a solid dispersion suspension.

[0055] Step 4: Suction filtration: Suction filtration of the solid dispersion suspension obtained in Step 3 to obtain a filter cake.

[0056] Step 5: Drying: vacuum-dry the filter cake obtained in...

Embodiment 3

[0064] A preparation of poly-L-lactic acid tissue filler, specifically comprising the following steps:

[0065] Step 1: Bulk polymerization: put 1kg of L-lactide and 0.7g of creatinine hydrochloride into the reactor, repeat 3 times of vacuuming to -0.095MPa, and fill with protective gas to make the reactor a protective gas atmosphere Vacuumize to -0.1MPa and seal; heat the reactor to 130°C and react for 10h;

[0066] Step 2: Dispersion: Add 5000ml of chloroform to the reactor in step 1, and stir and dissolve for 24 hours to obtain a solution;

[0067] Step 3: Purification: Slowly add the solution in Step 2 to ethanol dropwise at a rate of 1-3 L / min under stirring. After adding all the solution, continue stirring for 0.5 hours to obtain a solid dispersion suspension.

[0068] Step 4: Suction filtration: Suction filtration of the solid dispersion suspension obtained in Step 3 to obtain a filter cake.

[0069] Step 5: Drying: vacuum-dry the filter cake obtained in Step 4 at 45°...

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Abstract

The invention discloses a preparation method of a poly-L-lactic acid tissue filling agent, and belongs to the field of medical treatment. The poly-L-lactic acid tissue filling agent is used for tissuefilling. The preparation method comprises the following steps: preparing poly-L-lactic acid into material microspheres, dissolving the material microspheres with an excipient, a freeze-drying protective agent and a suspending agent in proportion, filling, and freeze-drying to obtain a tissue filling injection for tissue filling. The invention discloses the poly-L-lactic acid tissue filling agentof which the safety is proved by accumulation of a large amount of clinical data. The poly-L-lactic acid tissue filling agent comprises proper molecular weight, microsphere size and a preparation process of a freeze-drying dosage form.

Description

technical field [0001] The invention relates to the fields of medical treatment and cosmetology, in particular to a preparation method of a poly-L-lactic acid tissue filler. Background technique [0002] Poly-L-lactic acid is a synthetic, highly biocompatible and biodegradable polymer material emerging in modern times. It is a polymer material with controllable molecular weight obtained by one-step polymerization of L-lactic acid or two-step polymerization of L-lactide. Early commonly used catalysts were tin-based reagents, which limited its scope of application to a certain extent. At present, non-metallic catalyzed polymerization is used, with almost zero heavy metal ions, and its application in the biomedical field has been further broadened. [0003] The material has a wide range of degradation time, from 1 month to 5 years or even longer, and its degradation rate is related to various factors such as the external environment and molecular weight. Generally speaking, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50
CPCA61L27/18A61L27/50A61L2400/06
Inventor 尹振宇邵云鹏陈亮
Owner 吉林省杭盖秱博生物科技有限公司
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