Synergistic herbal compositions for the treatment of obesity and overweight

A synergistic composition, the technology of the composition, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve problems such as unacceptable side effects

Pending Publication Date: 2020-12-11
LAILA NUTRACEUTICALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many agents were commercialized to address obesity, but most were withdrawn from the market due to unacceptable side effects

Method used

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  • Synergistic herbal compositions for the treatment of obesity and overweight
  • Synergistic herbal compositions for the treatment of obesity and overweight
  • Synergistic herbal compositions for the treatment of obesity and overweight

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0083] Example 1: Preparation of an aqueous extract of cocoa seeds

[0084] Cocoa dried seeds (100 g) were crushed and the powdered material was extracted with water (700 mL) in a laboratory extractor for 1 h at room temperature (rt). The extract was filtered and the spent material was re-extracted twice with water (2 x 500 mL) under similar conditions. The combined extracts were filtered and concentrated under vacuum to give the residue of the aqueous extract as a powder (T.C-1; 14 g).

example 2

[0085] Example 2: Preparation of Ethanol and 50% Ethanol-Aqueous Extracts of Cocoa Seeds

[0086] Cocoa dried seeds (100 g) were crushed and the powdered material was extracted with 50% aqueous ethanol (700 mL) in a laboratory extractor for 1 hour at room temperature. The extract was filtered and the spent material was re-extracted twice with 50% aqueous ethanol (2 x 500 mL) under similar conditions. The combined extracts were filtered and concentrated in vacuo to give a residue of the ethanol extract (T.C-2; 11 g).

[0087] An ethanol extract (T.C-3; 4.4 g) of cacao seeds (100 g) was obtained by the same method as above using ethanol as an extraction solvent.

example 3

[0088] Example 3: Preparation of 50% aqueous methanol extract of cocoa seeds

[0089]Cocoa dried seeds (100 g) were crushed and the powdered material was extracted with 50% aqueous methanol (700 mL) in a laboratory extractor for 1 h at room temperature. The extract was filtered and the spent material was re-extracted twice with 50% methanol (2 x 500 mL) under similar conditions. The combined extracts were filtered and concentrated under vacuum to obtain a residue of 50% aqueous methanol extract (T.C-4; 10 g).

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PUM

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Abstract

The invention discloses synergistic herbal composition comprising combination of first ingredient selected from extracts, fractions, phytochemicals and mixtures thereof derived from Theobroma cacao and a second ingredient selected from extracts, fractions, phytochemical and mixtures thereof derived from Citrus aurantifolia for obtaining at least one health benefit selected from preventing, controlling or treating obesity and / or overweight; improving lean body mass, improving the browning of White Adipose Tissue / improving formation of brown adipose tissue, increasing basal metabolic rate / resting energy expenditure, increasing thermogenesis, improving thyroid function, maintaining healthy body weight, increasing satiety / , supporting weight loss, improving fat loss and maintaining a slim body. The invention further discloses synergistic herbal compositions comprising Theobroma cacao and Citrus aurantifolia and optionally comprises at least one ingredient selected from pharmaceutically acceptable excipient / diluent / carrier; methods of treatment and use for the prevention and treatment of obesity / overweight or improving lean body mass or resting energy expenditure in a human or animal.

Description

technical field [0001] The present invention relates to a synergistic herbal composition comprising a first component selected from cocoa extracts, fractions, phytochemicals and mixtures thereof and a second component selected from lemon extracts, fractions, phytochemicals and mixtures thereof and optionally comprising at least one ingredient selected from pharmaceutically acceptable excipients, diluents and carriers or mixtures thereof, to obtain at least one ingredient selected from the group consisting of preventing, controlling or treating obesity and / or overweight health benefits; improved lean body mass, improved browning of white adipose tissue (WAT) / improved formation of brown adipose tissue (BAT), increased basal metabolic rate (BMR) / resting energy expenditure, increased thermogenesis, improved thyroid function, Maintain a healthy weight, increase satiety, support weight loss, improve fat loss, and maintain a lean figure. The present invention also relates to a metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K8/98A61P1/00A61P43/00
CPCA61K36/185A61K36/752A61P3/04A61K2236/333A61Q19/06A61K2800/5922A61K8/9789A61K2300/00A23L29/35A23L33/105A23L33/125A23L33/40A23V2002/00A61K9/0056A61K9/0058A61K47/36
Inventor 根加拉朱·戈卡拉朱文卡塔肯纳卡兰加拉朱·戈卡拉朱罗摩拉朱·戈卡拉朱特瑞穆尔图卢·戈拉科蒂基兰·布帕蒂拉朱文卡特斯瓦鲁·索米帕里文卡塔克里希那拉朱·埃卢瑞克里尚努·森古普塔
Owner LAILA NUTRACEUTICALS
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