A kind of compound extracted and separated from Rhododendron chinensis and the application of the compound in the preparation of antidiabetic drugs

Abstract

The present invention relates to the technical field of medicinal compounds, and specifically discloses a new compound 3 extracted and separated from Rhododendron chinensis β , 23‑dihydroxy‑28‑norolean‑12‑ene‑16‑one, and the application of the new compound in the preparation of antidiabetic drugs. The present invention uses modern spectrum techniques such as 1D-NMR, 2D-NMR, high-resolution mass spectrometry, etc. to identify the structure of the isolated monomer compound, and deduce the molecular structure of the compound. The results of enzyme activity experiments showed that the new compound has a good inhibitory effect on protein tyrosine phosphatase 1B (PTP1B), α ‑Glucosidase activity. The results of molecular docking showed that the new compound had good binding activity with the target protein, and the interaction force was mainly hydrogen bond and hydrophobic force. The new compound has a good hypoglycemic effect and has a good application prospect in the treatment of diabetes.

Description

technical field [0001] The invention relates to the technical field of medicinal compounds, in particular to a new compound 3β,23-dihydroxy-28-norolean-12-ene-16-one (3β,23-dihydroxy-28-one (3β,23-dihydroxy-28- Norcarb-olean-12-en-16-one) and the application of the new compound in the preparation of antidiabetic drugs. Background technique [0002] Caulophyllum robustum Maxim. is the root and rhizome of Berberidaceae plant Caulophyllum robustum Maxim. It is also known as Caulophyllum robustum Maxim. Hongmaoqi is mainly produced in Heilongjiang, Shaanxi, Liaoning, Gansu, Hubei and other places. It grows in the shade and damp places of ravines at an altitude of about 950-3500 meters, under forests or under bamboo forests. It is used as a Tujia national medicine in Hubei Province. Its roots and rhizomes are used as medicines. It has the functions of expelling wind and dampness, clearing away heat and detoxification, promoting blood circulation and removing blood stasis, loweri...

AI Technical Summary

Problems solved by technology

[0004] At present, scholars at home and abroad are mainly studying the biological activity of the traditional Chinese medicine Hongmaoqi. There are few studies on the specific pharmacological activities of the chemical components contained in it. It is mostly used in combination with other medicinal materials. The components are complex and its mechanism of action is still unclear. There are no relevant literatures about the anti-diabetic effects of triterpenoid saponins, and the structure of the triterpenoids has strong specificity. Therefore, starting from the isolation and identification of the monomeric compounds, find the active ingredients that exert various medicinal effects , in order to conduct in-depth research, development and utilization, it is of great significance

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