A kind of synthetic method of 1,1'-diamino-5,5'-bitetrazole
A synthesis method, the technology of bitetrazole, which is applied in the field of synthesis of 1,1'-diamino-5,5'-tetrazole, can solve the problem of low yield of bitetrazole, and achieve simple operation and reduced operation Process, high purity effect
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Embodiment 1
[0025] Add 1.0g of 1,1'-dicarbamate-5,5'-bitetrazole to dissolve in 10ml of methanol, put the solution into a sealed tube (specifically, a sealed reaction kettle commonly used in the chemical industry), and then add 0.52 g NaOH, seal the sealed tube and place it in an oil bath, heat it to 156°C, and react for 10 hours; then cool down, pour the reaction solution into 30ml water, extract with 3×10ml ethyl acetate, and wash the organic layer with anhydrous NaOH 2 SO 4 After drying, the solvent was removed by rotary evaporation under reduced pressure to obtain 0.27 g of solid powder 1,1'-diamino-5,5'-bitetrazole, with a yield of 50% and a purity of 98.6% (HPLC).
[0026] Structure Identification:
[0027] Infrared Spectrum: IR(KBr,cm -1 )υ: 3443,3338,3321,3259,3173,1621,1409,1388,1277,1132,1034,991,959,924,667;
[0028] NMR spectrum: 13 C NMR (DMSO-d 6 ,125MHz), δ:141.62(2C); 1 H NMR (DMSO-d 6 ,500MHz), δ:7.44(2NH 2 );
[0029] Elemental analysis: Molecular formula C2H4N1...
Embodiment 2
[0033] Add 1.0g of 1,1'-dicarbamate-5,5'-bitetrazol to 10ml of methanol to dissolve, put the solution into a sealed tube, then add 0.72g of KOH to it, seal the sealed tube and put In an oil bath, heat to 150°C and react for 10 hours; then cool down, pour the reaction solution into 30ml of water, extract with 3×10ml of ethyl acetate, and wash the organic layer with anhydrous Na 2 SO 4 After drying, the solvent was removed by rotary evaporation under reduced pressure to obtain 0.23 g of solid powder 1,1'-diamino-5,5'-bitetrazole, with a yield of 43% and a purity of 97.6% (HPLC).
Embodiment 3
[0035] Add 1.0g of 1,1'-dicarbamate-5,5'-bitetrazol to 10ml of ethanol to dissolve, put the solution into a sealed tube, then add 0.72g of KOH to it, seal the sealed tube and put it into In an oil bath, heat to 153°C and react for 10 hours; then cool down, pour the reaction solution into 30ml of water, extract with 3×10ml of ethyl acetate, and wash the organic layer with anhydrous Na 2 SO 4 After drying, the solvent was removed by rotary evaporation under reduced pressure to obtain 0.25 g of solid powder 1,1'-diamino-5,5'-bitetrazole, with a yield of 47% and a purity of 93.2% (HPLC).
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