A nanorod array coating with thermal control immunity and anti-oxidation functions, its preparation method and application

A nano-rod, anti-oxidation technology, applied in coatings, surface reaction electrolytic coatings, pharmaceutical formulations, etc., can solve the problems of lack of immune modulation ability, inapplicability to clinical applications, and lack of anti-oxidation functions, etc., to achieve process stability , Dip coating method is simple, the effect of strong oxidation self-polymerization ability

Active Publication Date: 2022-04-22
陕西佳诺博奥生物科技有限公司
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Problems solved by technology

[0003] Studies have shown that the structured surface layer of hydroxyapatite (HA) nanorod arrays constructed by bone-like matrix and components can significantly promote the osteogenic behavior of osteoblast-related cells, but the arrayed coating still does not have anti-oxidation function and lack of immunomodulatory ability
In terms of enhancement of immune modulation function, studies have shown that thermal stimulation can polarize macrophages to the M2 phenotype, that is, "thermally controlled immunity". Compared with drug loading and chemical grafting, thermally controlled immune It has the characteristics of safety, simplicity and economy. However, the heat produced in the research is generally generated by direct heating, which is not suitable for clinical application.

Method used

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  • A nanorod array coating with thermal control immunity and anti-oxidation functions, its preparation method and application
  • A nanorod array coating with thermal control immunity and anti-oxidation functions, its preparation method and application
  • A nanorod array coating with thermal control immunity and anti-oxidation functions, its preparation method and application

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Embodiment 1

[0037] A method for preparing a nanorod arrayed coating with functions of thermal control immunity and anti-oxidation, comprising the following steps:

[0038]Step 1. Perform micro-arc oxidation. The parameters of the micro-arc oxidation are set as follows: set the arc frequency of the micro-arc oxidation to 100 Hz, the power supply to a positive voltage of 400 V, and the duty cycle to 7.5%. In the micro-arc oxidation process, titanium or its alloy disc is used as the anode, and the stainless steel electrolytic cell is used as the cathode. The composition and concentration of the electrolyte are: sodium hydroxide (NaOH) 0.005mol / L, calcium acetate (Ca(CH 3 COO) 2 ) 0.22mol / L, β-glyceride phosphate disodium salt pentahydrate (β-GP) 0.02mol / L. During the preparation process, a cooling system is used to control the temperature of the micro-arc oxidation electrolyte to 303K. After micro-arc oxidation, the sample coated with titanium dioxide coating was obtained, and the prepared...

Embodiment 2

[0047] A method for preparing a nanorod arrayed coating with functions of thermal control immunity and anti-oxidation, comprising the following steps:

[0048] Step 1. Perform micro-arc oxidation. The parameters of the micro-arc oxidation are set as follows: set the arc frequency of the micro-arc oxidation to 100 Hz, the power supply to a positive voltage of 400 V, and the duty cycle to 7.5%. In the micro-arc oxidation process, titanium or its alloy disc is used as the anode, and the stainless steel electrolytic cell is used as the cathode. The composition and concentration of the electrolyte are: sodium hydroxide (NaOH) 0.005mol / L, calcium acetate (Ca(CH 3 COO) 2 ) 0.22mol / L, β-glyceride phosphate disodium salt pentahydrate (β-GP) 0.02mol / L. During the preparation process, a cooling system is used to control the temperature of the micro-arc oxidation electrolyte to 303K. After micro-arc oxidation, the sample coated with titanium dioxide coating was obtained, and the prepare...

Embodiment 3

[0057] A method for preparing a nanorod arrayed coating with functions of thermal control immunity and anti-oxidation, comprising the following steps:

[0058] Step 1. Perform micro-arc oxidation. The parameters of the micro-arc oxidation are set as follows: set the arc frequency of the micro-arc oxidation to 100 Hz, the power supply to a positive voltage of 400 V, and the duty cycle to 7.5%. In the micro-arc oxidation process, titanium or its alloy disc is used as the anode, and the stainless steel electrolytic cell is used as the cathode. The composition and concentration of the electrolyte are: sodium hydroxide (NaOH) 0.005mol / L, calcium acetate (Ca(CH 3 COO) 2 ) 0.22mol / L, β-glyceride phosphate disodium salt pentahydrate (β-GP) 0.02mol / L. During the preparation process, a cooling system is used to control the temperature of the micro-arc oxidation electrolyte to 303K. After micro-arc oxidation, the sample coated with titanium dioxide coating was obtained, and the prepare...

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Abstract

The invention discloses a nanorod arrayed coating with functions of thermal control immunity and anti-oxidation, a preparation method and application thereof, and belongs to the technical field of biomedical materials. Firstly, a porous titanium dioxide coating containing phosphorus and calcium is prepared on the surface of titanium or its alloys by micro-arc oxidation, and then hydrothermal treatment is used to grow hydroxyapatite nanorods in situ on the porous titanium dioxide coating containing phosphorus and calcium. Finally, polydopamine-coated hydroxyapatite nanorod arrays were prepared by oxidative self-polymerization method, and finally a nanorod array coating with thermal control immunity and anti-oxidation functions was obtained. The process is stable and controllable; the surface layer of the prepared biomedical material has dual functions of anti-oxidation and light and heat; as an implant, it can heal and regenerate bone tissue, and avoid coating caused by poor membrane / substrate binding force. Detachment of the layer and the occurrence of side effects such as osteolysis or excessive inflammation induced by it.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a nanorod arrayed coating with functions of thermal control, immunity and anti-oxidation, as well as its preparation method and application. Background technique [0002] Titanium and its alloys are widely used in hard tissue replacement materials such as bones, teeth, and joints due to their good mechanical properties and biocompatibility. However, studies have shown that the failure rate after implantation is still high. The reasons: (1 ) Lack of antioxidant capacity: during surgical implantation of titanium-based implants, excessive reactive oxygen species (reactive oxygen species ROS, including superoxide anion O 2- , hydroxyl radical OH , hydrogen peroxide H 2 o 2 etc.) will destroy the microenvironment in the bone around the implant, induce excessive inflammation in the tissue, and lead to the failure of implant osseointegration; (2) Lack of immun...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/56A61L27/54A61L27/06A61L27/30A61L27/32A61L27/34C25D11/26
CPCA61L27/50A61L27/56A61L27/54A61L27/06A61L27/306A61L27/32A61L27/34C25D11/26C25D11/026A61L2300/204A61L2300/412A61L2300/426A61L2400/12A61L2400/18A61L2420/02A61L2420/06A61L2430/02C08L79/02
Inventor 李博刘福立憨勇
Owner 陕西佳诺博奥生物科技有限公司
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