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Pyrido[2,3-d]pyrimidine compound as well as preparation method and application thereof

A 3-d, compound technology, applied in the field of medicine, can solve the problems of high recurrence rate side effects, limited clinical treatment effect, etc.

Active Publication Date: 2021-01-05
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Traditional tumor treatment methods generally include surgical treatment, chemical drug treatment and radiotherapy, etc. These traditional tumor treatment methods usually have a high recurrence rate and various side effects, and the clinical treatment effect is limited

Method used

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  • Pyrido[2,3-d]pyrimidine compound as well as preparation method and application thereof
  • Pyrido[2,3-d]pyrimidine compound as well as preparation method and application thereof
  • Pyrido[2,3-d]pyrimidine compound as well as preparation method and application thereof

Examples

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Embodiment

[0081] The present invention is specifically described below by way of examples. It is necessary to point out that the following examples are only used to further illustrate the present invention, and can not be interpreted as limiting the protection scope of the present invention, some non-essential improvements made by those skilled in the art according to the content of the present invention above And adjustments still belong to the protection scope of the present invention.

[0082] The melting point of compound among the present invention adopts X-4 type melting point apparatus to measure, and temperature is uncorrected; Nuclear Magnetic Resonance spectrum adopts Inova-400MHz Nuclear Magnetic Resonance Instrument to measure, makes internal standard with tetramethylsilane; Mass spectrometry adopts Agilent1100 liquid-mass spectrometer Determination; Unless otherwise specified, all reagents used are commercially available, and the purity is chemical or analytical pure.

[0...

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PUM

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Abstract

The present invention discloses a pyrido[2,3-d]pyrimidine compound represented by a general formula I or a pharmaceutically acceptable salt thereof. The general formula I is shown as the specification, wherein R1 is selected from one of an alkylamine group of C1-C6, an alicyclic amine group of C1-C6, a heterocyclic amine group of C1-C6, and an aromatic amine group of C6-C8, and X represents a hydrogen atom or a halogen atom. According to the invention, in-vitro cell activity tests prove that the compound provided by the invention has antitumor activity and can be used for preparing medicines for treating and / or preventing various cancers caused by BRaf kinase mutation, such as melanoma, thyroid cancer, breast cancer, liver cancer, kidney cancer, colorectal cancer, pancreatic cancer, ovarian cancer, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a pyrido[2,3-d]pyrimidine compound, in particular to the compound and its preparation method and the anti-tumor effect of the compound in the treatment of melanoma, thyroid cancer, colorectal cancer and ovarian cancer. Uses in medicine. Background technique [0002] Malignant tumors are diseases caused by abnormal mechanisms controlling cell growth and proliferation. With the process of globalization, the world population continues to grow, the economy continues to develop, and the lifestyle changes accordingly. The incidence and mortality of malignant tumors continue to increase. According to reports, there are about 18 million new cases of malignant tumors in the world, and about 9.56 million deaths. In 2018 alone, there were more than 1,735,350 new cases and 609,640 new deaths. As the largest developing country in the world, China has an increasing incidence and mortality of m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/04A61K31/519A61P35/00
CPCA61P35/00C07D471/04
Inventor 周志旭
Owner GUIZHOU UNIV
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