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Anastomosis nail with anti-inflammatory function and preparation method thereof

A staple and functional technology, applied in the field of staplers, can solve the problems of patients' troubles, inflammation, etc., and achieve the effect of improving the quality of life

Active Publication Date: 2021-01-08
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after cutting and suturing, it will cause inflammation due to trauma, especially in circumcision surgery, which will cause great distress to patients

Method used

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  • Anastomosis nail with anti-inflammatory function and preparation method thereof
  • Anastomosis nail with anti-inflammatory function and preparation method thereof
  • Anastomosis nail with anti-inflammatory function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Surface hydroxylation of staples

[0023] Put the staples in the EPT-02 plasma surface treatment instrument, control the temperature at 25°C, power 2.5kw, time 20min, the treatment atmosphere is vacuum conditions, the plasma is oxygen plasma, and carry out surface hydroxylation treatment on the staples;

[0024] (2) Surface hydrazide of staples

[0025] Soak the surface-hydroxylated staples in a saturated acetone solution of 3-aminopropyltriethoxysilane, heat to 65°C, and react for 24 hours. After the reaction, wash with ethanol and dry; then take oxalic acid , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide are dissolved in water to prepare a mixed solution, wherein oxalic acid, 1-(3 -Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide in a molar ratio of 1:1:1, soak the previously treated staples in the mixed solution , reacted at room temperature for 24 hours, washed with deionized water and dried...

Embodiment 2

[0031] (1) Surface hydroxylation of staples

[0032] Put the staples in the EPT-02 plasma surface treatment instrument, control the temperature at 40°C, power 4kw, time 30min, the treatment atmosphere is vacuum condition, the plasma is oxygen plasma, and carry out surface hydroxylation treatment on the staples;

[0033] (2) Surface hydrazide of staples

[0034] Soak the surface-hydroxylated staples in a saturated acetone solution of 3-aminopropyltriethoxysilane, heat to 70°C, and react for 20 hours. After the reaction, wash with ethanol and dry; then take oxalic acid , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide are dissolved in water to prepare a mixed solution, wherein oxalic acid, 1-(3 -Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide in a molar ratio of 1:1.2:0.8, soak the previously treated staples in the mixed solution , reacted at room temperature for 20 hours, washed with deionized water and drie...

Embodiment 3

[0038] (1) Surface hydroxylation of staples

[0039]Put the staples in the EPT-02 plasma surface treatment instrument, control the temperature at 10°C, power 5kw, time 40min, the treatment atmosphere is vacuum conditions, the plasma is oxygen plasma, and carry out surface hydroxylation treatment on the staples;

[0040] (2) Surface hydrazide of staples

[0041] Soak the surface-hydroxylated staples in a saturated acetone solution of 3-aminopropyltriethoxysilane, heat to 80°C, and react for 30 hours. After the reaction, wash with ethanol and dry; then take oxalic acid , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide are dissolved in water to prepare a mixed solution, wherein oxalic acid, 1-(3 -Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide in a molar ratio of 1:0.8:1, soak the previously treated staples in the mixed solution , reacted at room temperature for 30 hours, washed with deionized water and dried,...

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Abstract

The invention discloses an anastomosis nail with an anti-inflammatory function and a preparation method thereof. The surface of the anastomosis nail is coupled with a pH-responsive anti-inflammatory drug release layer. The preparation method comprises the following steps: performing surface hydroxylation treatment on the anastomosis nail by using a plasma surface treatment instrument; then carrying out surface hydrazide treatment on the anastomotic surface; and finally, soaking the anastomosis nail with the hydrazide surface in an ethanol solution containing excessive dexamethasone to preparethe anastomosis nail with the anti-inflammatory function. According to the anastomosis nail with the anti-inflammatory function, the mechanical property is not changed, but the surface is modified with anti-inflammatory drugs such as dexamethasone through hydrazone bonds, so that dexamethasone can be released at an inflammatory part when inflammation occurs after an operation to achieve the timelyanti-inflammatory effect, the effect is far higher than that of oral administration and injection of the anti-inflammatory drugs, the systemic side effect is avoided, and the life quality of patientsis improved.

Description

technical field [0001] The invention relates to a stapler, in particular to a stapler containing dexamethasone and having an anti-inflammatory function and a preparation method thereof. Background technique [0002] As a modern medical device that replaces traditional manual suturing, the stapler is reliable in quality, easy to use, tight and suitable for tightness, especially its fast suturing and few side effects and surgical complications, and is favored by clinical surgeons. and respected. However, after cutting and suturing, it will cause inflammation due to trauma, especially in the circumcision operation, which will cause great distress to the patient. Studies have shown that when inflammation occurs, the catabolism of the three major nutrients in the inflamed area is enhanced, and the H in the inflamed area + The rapid increase will lead to a sharp drop in pH. Drugs such as dexamethasone, as glucocorticoids, can prevent the synthesis and release of inflammatory med...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/08C23C22/73C23C22/78
CPCA61L31/08A61L31/16A61L2300/216A61L2300/41A61L2300/606C23C22/73C23C22/78
Inventor 柳森叶玮丁红燕张超刘静静厉虹
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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