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Near-infrared electrochemiluminescence compounds, electrochemiluminescence systems and their applications

A luminescent compound and chemiluminescence technology, which is applied in ruthenium organic compounds, platinum group organic compounds, organic chemistry, etc., can solve the problem of single luminous color, achieve good spatial resolution, deep penetration ability, and good electrochemiluminescence efficiency Effect

Active Publication Date: 2021-03-16
SUZHOU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the terpyridine ruthenium complex Ru(bpy) 3 2+ It is the most common type of electrochemiluminescent signal labeling molecules, but the luminescent color is single (orange red, the maximum emission wavelength is about 610nm), and it is extremely difficult to further redshift the wavelength to near infrared region

Method used

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  • Near-infrared electrochemiluminescence compounds, electrochemiluminescence systems and their applications
  • Near-infrared electrochemiluminescence compounds, electrochemiluminescence systems and their applications
  • Near-infrared electrochemiluminescence compounds, electrochemiluminescence systems and their applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The partial structure of the positive monovalent cation of the electrochemiluminescent compound used is shown below:

[0045]

[0046] Synthesis of Electrochemiluminescent Compounds:

[0047]First react benzimidazole with p-iodobenzotrifluoride to obtain a ligand precursor, then react the ligand precursor with methyl iodide to obtain a C^C bidentate ligand, and then further compound C^C* bidentate The intermediate is reacted with dichlorobis(4-methylisopropylphenyl)ruthenium (II) to obtain the intermediate, and finally the intermediate is reacted with the N^N bidentate ligand to obtain the final electrochemiluminescence compound.

[0048] The glassy carbon electrodes in the electrochemiluminescent system involved in the present invention all use Al 2 o 3 Polishing powder sanding, washing, drying.

[0049] In the acetonitrile solution system, the concentration of the electrochemiluminescence compound was 0.1 mmol / L, tetrabutylammonium hexafluorophosphate was used a...

Embodiment 2

[0053] The partial structure of the positive monovalent cation of the electrochemiluminescent compound used is shown below:

[0054]

[0055] In the acetonitrile solution system, the concentration of the electrochemiluminescence compound was 0.1 mmol / L, tetrabutylammonium hexafluorophosphate was used as the supporting electrolyte at a concentration of 0.1 mol / L, and tripropylamine was used as a co-reactive molecule at a concentration of 40 mmol / L. L, using the cyclic potential scanning method (the potential range is -0.95V ~ +1.74 V, the scanning speed is 50mV / S, and the potential is based on NHE as a reference), and the electrochemiluminescent signal is collected by using a photomultiplier tube. The wavelength of the electrochemiluminescence peak is 824 nm.

[0056] In the acetonitrile solution system, the concentration of the electrochemiluminescence compound was 0.1 mmol / L, tetrabutylammonium hexafluorophosphate was used as the supporting electrolyte at a concentration o...

Embodiment 3

[0058] The partial structure of the positive monovalent cation of the electrochemiluminescent compound used is shown below:

[0059]

[0060] In the acetonitrile solution system, the concentration of the electrochemiluminescence compound was 0.1 mmol / L, tetrabutylammonium hexafluorophosphate was used as the supporting electrolyte at a concentration of 0.1 mol / L, and tripropylamine was used as a co-reactive molecule at a concentration of 40 mmol / L. L, using the cyclic potential scanning method (the potential range is -1.08 V to +1.49 V, the scanning speed is 50 mV / S, and the potential is based on NHE as a reference), and the electrochemiluminescence signal is collected by using a photomultiplier tube. The wavelength of the electrochemiluminescence peak is 815 nm.

[0061] In the acetonitrile solution system, the concentration of the electrochemiluminescence compound was 0.1 mmol / L, tetrabutylammonium hexafluorophosphate was used as the supporting electrolyte at a concentrati...

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Abstract

The near-infrared electrochemiluminescence compound, electrochemiluminescence system and application thereof of the present invention, wherein the near-infrared electrochemiluminescence compound is a bidentate ligand metal complex, the wavelength of its electrochemiluminescence peak can reach the near-infrared region, and can be formulated into The electrochemiluminescence system has excellent electrochemiluminescence efficiency in various luminescence modes.

Description

technical field [0001] The invention belongs to the technical field of electrochemiluminescence systems, and in particular relates to a near-infrared electrochemiluminescence compound, an electrochemiluminescence system and applications thereof. Background technique [0002] In the past few decades, imaging techniques based on fluorescence in the near-infrared region have played a huge role in the study of physiological or pathological processes in living organisms. Near-infrared luminescence has deeper penetration, better spatial resolution, and reduces photodamage to biological tissues. Compared with near-infrared fluorescence, near-infrared electrochemiluminescence can greatly reduce background noise and improve signal-to-noise ratio because it does not require an excitation light source. Therefore, the development of near-infrared electrochemiluminescent dyes has received extensive attention. At present, the terpyridine ruthenium complex Ru(bpy) 3 2+ It is the most c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/00C09K11/06G01N21/64
CPCC07F15/0046C09K11/06C09K2211/1029C09K2211/1044C09K2211/1059C09K2211/185G01N21/6428
Inventor 丁杨铭周宇扬陈丰
Owner SUZHOU UNIV OF SCI & TECH
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