Compounded lidocaine periodontal gel and preparation method therefor

Abstract

The invention discloses compounded lidocaine periodontal gel and a preparation method therefor. The compounded lidocaine periodontal gel comprises the following ingredients in parts by weight: 0.1-4.5parts of lidocaine, 0.1-4.5 parts of prilocaine, 3-10 parts of poloxamer 188, 4-25 parts of poloxamer 407, 0.05-2 parts of vitamin p, 30-120 parts of purified water and 2-7 parts of diluted hydrochloric acid. According to the compounded lidocaine periodontal gel and the preparation method therefor, provided by the invention, the carry-over is convenient, the use is convenient, the treatment effect is good, and the effect taking speed is high. Compared with the traditional injection anesthetization, the gel has the advantages that the effect is remarkable during periodontal pocket anesthetization, the depth of a periodontal pocket and an attached level of gums cannot be affected in periodontal scaling and root face leveling treatment, and the aching feeling is lowered. The gel has a very good popularization value.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound lidocaine periodontal gel and a preparation method thereof. Background technique [0002] Periodontitis is a common disease and a high incidence of human beings. The World Health Organization has identified it as the third major killer of human beings after cancer and cardiovascular diseases. Including diseases caused by chronic infection of gums, periodontal ligament, and alveolar bone. It will cause inflammation and bleeding of the gums, formation of periodontal pockets, alveolar bone absorption with a knife, loosening and displacement of teeth, and in severe cases, tooth loss. In addition, periodontal conditions are also closely related to general health. Pathogenic bacteria present in periodontal tissues can produce endotoxins, which may cause other diseases such as atherosclerosis and myocardial infarction. [0003] During clinical treatment, gel anest...

AI Technical Summary

Problems solved by technology

Local injection anesthesia sometimes has adverse reactions, and the injection process is likely to cause discomfort and fear in patients. The anesthesia effect of periodontal pocket gel at this stage is weak, and it is not suitable for pulp anesthesia and dentin hypersensitivity. The promotion is poor and the application range is limited.