The invention discloses
minocycline hydrochloride nano sustained-release gel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The problem of low encapsulation efficiency of small-molecule hydrophilic medicines is solved by introducing a form of a novel complex formed by chelating
minocycline hydrochloride,
metal ions and a compound with a plurality of
sulfate,
sulfonate or
phosphate functional groups. Prepared
minocycline hydrochloride multiple
emulsion nanoparticles are smooth, round, high in encapsulation efficiency and strong in
drug loading capacity. A prepared
minocycline hydrochloride multiple
emulsion nanoparticle is dispersed in a temperature-sensitive
gel matrix to construct a double-layer
delivery system which has certain
biological adhesion, is good in periodontal retention and is convenient for administration. According to the
minocycline hydrochloride nano sustained-release gel as well as the preparation method and application thereof, while the positioning
advantage of the gel is exerted, burst release of a
medicine can be remarkably reduced, the
medicine administration period can be prolonged, possibility is created for further periodontal pocket local
medicine administration treatment of
periodontitis, the nanoparticles can penetrate through alveolar bone trabecula and bottom
connective tissue, distribution of the medicine at a focus position is enhanced, and the
antibacterial effect of the medicine is remarkably improved.