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Medicine vein filter and manufacturing method thereof

A manufacturing method and filter technology, which is applied in the field of medical devices, can solve the problems such as the difficulty in taking out the endothelialization of the filter and the inability to meet the time of thrombolytic treatment, etc., and achieve the effect of slowing down the proliferation of endothelial cells, slowing down the proliferation of endothelial cells, and extending the recovery time window

Pending Publication Date: 2021-02-09
浙江博毅云华医疗器械有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the deficiencies of the prior art, the purpose of the present invention is to provide a drug intravenous filter and its manufacturing method. By setting the drug-loading tank to carry the drug, it is difficult to remove the endothelialization of the filter, and the recovery time window of the intravenous filter cannot meet the thrombolytic treatment time. The problem

Method used

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  • Medicine vein filter and manufacturing method thereof
  • Medicine vein filter and manufacturing method thereof
  • Medicine vein filter and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The filter body 11 obtained by laser cutting is polished, then cleaned and dried;

[0042] Preparation of electrolyte: Add 1ml of nitric acid, 150ml of ethylene glycol solution and 150ml of glycerol solution into 200ml of purified water, and mix well;

[0043] Add the electrolyte solution into the electrolytic cell, put the filter body 11 as the anode into the electrolytic cell, and react at a voltage of 20-40V for 100s to obtain a drug-loading cell 13 with a depth of 1 μm-5 μm and a pore cross-sectional area of ​​0.1-30 μm 2 The filter body 11.

[0044] Preparation of drug solution: add 100mg of rapamycin to 10ml of acetone and mix well;

[0045] The filter body 11 with the drug-loading groove 13 was immersed in the drug solution, ultrasonically treated for 15 minutes, taken out and dried, and the sample 1 of the drug intravenous filter was obtained.

Embodiment 2

[0047] The filter body 11 obtained by laser cutting is polished, then cleaned and dried;

[0048]Preparation of electrolyte: Add 10ml of nitric acid, 50ml of ethylene glycol solution and 40ml of glycerol solution into 400ml of purified water, and mix well;

[0049] Add the electrolyte solution into the electrolytic cell, put the filter body 11 as the anode into the electrolytic cell, and react at a voltage of 5-20V for 100s to obtain a drug-loading cell 13 with a depth of 5 μm-10 μm and a cavity cross-sectional area of ​​30-100 μm 2 The filter body 11.

[0050] Preparation of drug solution: add 100mg of rapamycin to 10ml of acetone and mix well;

[0051] The drug solution is atomized and sprayed onto the drug-loading groove 13 of the filter body 11 by means of an ultrasonic atomization spraying device, and left to dry to obtain a sample 2 of the drug intravenous filter.

[0052] 1. Comparison experiment of endothelial cell proliferation thickness:

[0053] Use the drug vein...

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Abstract

The invention discloses a medicine vein filter and a manufacturing method thereof. The medicine vein filter comprises a filter body, a supporting structure arranged on the filter body, a medicine carrying tank formed in the contact part between the supporting structure and a blood vessel wall, and medicine arranged in the medicine carrying tank. According to the medicine carrying tank carrying themedicine and obtained through the manufacturing method, proliferation of endothelial cells is slowed down, the wrapping thickness of the endothelial cells on the filter is reduced, the recovering difficulty of the filter is greatly reduced, and due to the fact that proliferation of the endothelial cells is slowed down, the recovering time window of the filter is effectively prolonged.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug vein filter and a manufacturing method thereof. Background technique [0002] Deep venous thrombosis (DVT) of lower extremities is a common clinical disease and the main cause of pulmonary embolism (PE). Pulmonary embolism has a high mortality and disability rate. The placement of an inferior vena cava filter (IVCF) can effectively prevent pulmonary embolism. The basic principle is to capture large fatal emboli through the filter placed in the vena cava and prevent them from entering the pulmonary circulation. The use of venous filters is now more and more widespread. In order to improve the use effect of the filter, reduce the influence of complications, and make the thrombolytic therapy safer, people continue to propose new design schemes for the filter. [0003] The main problems in the clinical use of existing filters are: 1. Endothelialization. After the filter is pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/01
CPCA61F2/01A61F2002/018A61F2240/001A61F2250/0067
Inventor 陈祥亨周云鹏李秋华
Owner 浙江博毅云华医疗器械有限公司
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