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Disinfection coupling gel special for medical ultrasound and preparation method thereof

A gel and ultrasonic technology, applied in botany equipment and methods, disinfectants, pharmaceutical formulations, etc., can solve the problems of low safety, emulsification of surfactants, corrosion and damage of probes, etc., and achieve excellent sterilization effect and easy operation Controllable, safe and reliable effect

Inactive Publication Date: 2021-02-12
四川奥洁科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, several medical disinfection coupling agents have been disclosed, some of which use traditional Chinese medicine extracts as the main disinfection components, which need to be dissolved in ethanol and added with surfactants. The disadvantage of this medical coupling agent is that it is easy to cause corrosion damage to the probe. And the surfactant in it is prone to emulsification and affects the effect of ultrasound
Chinese patent application 2019106457174 discloses a new medical disinfection ultrasonic coupling agent, its raw materials include hydantoin complex, carbomer, glycerin, EDTA-2Na, sodium hydroxide and water, and the strong alkali sodium hydroxide has a certain effect on the probe Corrosive, at the same time, it mainly uses a compound composed of 5-5-dimethylhydantoin and 8-carbon dialdehyde as the active material for sterilization and anti-corrosion. Its raw materials are difficult to obtain, and homogeneous equipment is required, and the preparation process is relatively complicated.
Chinese patent CN 105709244 B discloses a medical ultrasonic coupling agent, which uses polyether compounds A and B, chlorinated aromatic ether compounds and phenoxyethanol as raw materials, which has high organic toxicity, damage to human body, and low safety in use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A special disinfection coupling gel for medical ultrasound, its raw material formula is calculated by weight percentage: 0.25% of lysozyme, 0.3% of antimicrobial peptide (food grade ε-polylysine), cypress extract (active ingredient content greater than 10%) ) 1%, Sophora flavescens extract (active ingredient content greater than 10%) 1%, 1,2-propanediol 3%, citric acid 0.1%, vitamin B5 0.005%, water-based rheology modifier (guar gum) 1% , The balance is made up with purified water.

[0026] Its preparation method comprises the following steps:

[0027] (1) According to the above raw material formula, take purified water accounting for 60% of the total mass fraction, add an aqueous rheology modifier to it, and stir for 1 hour to obtain a transparent gel for use;

[0028] (2) According to the above raw material formula, take lysozyme, antimicrobial peptide, citric acid, vitamin B5 and the rest of purified water, stir at room temperature for 1 hour, after fully dissolving...

Embodiment 2

[0030] A special disinfection coupling gel for medical ultrasound, its raw material formula is calculated by weight percentage: 0.12% of lysozyme, 0.4% of antibacterial peptide (food grade ε-polylysine), cypress extract (active ingredient content 15%) 2% and Sophora flavescens extract (active ingredient content 20%) 2%, 1,2-propanediol 4%, citric acid 0.15%, vitamin B50.008%, water-based rheology modifier (guar gum) 3%, surplus Make up with purified water.

[0031] Its preparation method comprises the following steps:

[0032] (1) According to the above raw material formula, take purified water accounting for 80% of the total mass fraction, add an aqueous rheology modifier therein, and stir for 1 hour to obtain a transparent gel for use;

[0033] (2) According to the above raw material formula, take lysozyme, antimicrobial peptide, citric acid, vitamin B5 and the rest of purified water, stir at room temperature for 1 hour, after fully dissolving, add 1,2-propanediol, cypress ...

Embodiment 3

[0035] A special disinfection coupling gel for medical ultrasound, its raw material formula is calculated by weight percentage: 0.15% of lysozyme, 0.5% of antimicrobial peptide (food grade ε-polylysine), cypress extract (active ingredient content 20%) 2%, Sophora flavescens extract (active ingredient content 20%) 2%, 1,2-propanediol 5%, citric acid 0.2%, vitamin B5 0.01%, water-based rheology modifier (guar gum) 2%, surplus Make up with purified water.

[0036] Its preparation method comprises the following steps:

[0037] (1) According to the above raw material formula, take purified water accounting for 75% of the total mass fraction, add an aqueous rheology modifier to it, and stir for 1 hour to obtain a transparent gel for use;

[0038] (2) According to the above raw material formula, take lysozyme, antibacterial peptide, citric acid, vitamin B5 and the rest of purified water, stir at room temperature for 1 hour, after fully dissolving, add 1,2-propanediol, cypress extrac...

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Abstract

The invention provides disinfection coupling gel special for medical ultrasound and a preparation method thereof, and belongs to the technical field of medical ultrasound imaging agents. The disinfection coupling gel special for medical ultrasound provided by the invention is prepared from the following raw materials in percentage by weight: 0.05 to 0.25 percent of lysozyme, 0.3 to 0.6 percent ofantibacterial peptide, 1 to 6 percent of cypress extracting solution, 1 to 6 percent of radix sophorae flavescentis extracting solution, 3 to 7 percent of 1, 2-propylene glycol, 0.1 to 0.4 percent ofcitric acid, 0.005 to 0.02 percent of vitamin B5, 1 to 5 percent of water-based rheology regulator and the balance of purified water. The raw materials of the disinfection coupling gel special for medical ultrasound provided by the invention are mainly natural plant components and bioactive components, the sterilization effect is excellent, the use is safe and reliable, and the raw material components are easy to obtain; the preparation process is simple, the operation is convenient, complex equipment is not needed, and the application prospect is better.

Description

technical field [0001] The invention belongs to the technical field of medical ultrasound imaging agents, and in particular relates to a special disinfection coupling gel for medical ultrasound and a preparation method thereof. Background technique [0002] Medical ultrasonic coupling agent has been widely used as a sound-transmitting medium in the field of medical ultrasonic diagnosis and treatment, and has been widely used in the imaging detection of various ultrasonic imaging equipment in clinical practice. With the continuous development of the field of ultrasonic diagnosis, ultrasonic equipment has been widely used in hospitals at all levels. At this time, it is necessary to disinfect the ultrasonic equipment in time, especially for ultrasonic probes that are in direct contact with human skin. It is more important to disinfect them. For the most important, so the sterile coupling agent in medical ultrasound came into being. [0003] At present, several medical disinfec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N65/20A01N63/50A01N31/02A01N37/36A01N37/46A01P1/00A61K49/22
CPCA01N31/02A01N37/36A01N37/46A01N65/00A01N65/06A01N65/20A61K49/22A61K49/222A01N63/50
Inventor 钟朝斌胡顺铁
Owner 四川奥洁科技有限公司
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