Application of oridonin in preparation of drugs for treating hyperuricemia and resisting gout

A technology for hyperuricemia and oridonin A is applied in pharmaceuticals, and the application field of oridonin A in the preparation of drugs for treating hyperuricemia and anti-gout can inhibit the activity of xanthine oxidase and achieve a remarkable effect. , Improve the effect of large side effects

Active Publication Date: 2021-02-26
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the use of Rubescensine A as the active ingredient in the prevention and / or treatment of hyperuricemia and gout has not been reported

Method used

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  • Application of oridonin in preparation of drugs for treating hyperuricemia and resisting gout
  • Application of oridonin in preparation of drugs for treating hyperuricemia and resisting gout
  • Application of oridonin in preparation of drugs for treating hyperuricemia and resisting gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Effects of oridonin on hyperuricemia induced by yeast powder and potassium oxonate.

[0028] 40 healthy male Kunming mice, weighing 18-20 g, were provided by Animal Experiment Center of Henan Province. The mice were adaptively fed for one week in the SPF grade animal room of the School of Pharmacy, Zhengzhou University, Henan Province, and were divided into 4 groups using the random number table method, with 10 mice in each group, as follows:

[0029] 1. Normal control group;

[0030] 2. Model control group;

[0031] 3. Rubescensine A group;

[0032] 4. Positive control drug group.

[0033] After the adaptation period was over, the drug was given by gavage twice a day in the morning. First, the model control group, Rubescensin A group, and positive control group were given intragastric administration of yeast powder (30g / kg), and the normal control group was given the same amount of normal saline for intragastric administration; 1h later, the Oridonin A group was gi...

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Abstract

The invention belongs to the field of medicinal chemistry, and relates to an application of oridonin in preparation of drugs for treating hyperuricemia and resisting gout. The invention provides a newapplication of oridonin as a unique effective component or a main effective component in preparation of drugs for treating hyperuricemia and resisting gout. The application amount of oridonin in miceis intragastric administration according to 10 mg / kg body weight, and oridonin can reduce the serum uric acid level after administration, inhibits the xanthine oxidase activity in liver tissues, produces the effects of treating hyperuricemia and resisting gout, and has the advantages of small dosage, no obvious toxicity to liver and kidney, and the like. The invention opens up a new application of oridonin, and provides a new direction for improving the phenomenon of large side effects of existing drugs for resisting gout.

Description

technical field [0001] The invention relates to pharmaceutical technology and belongs to the field of medicinal chemistry, in particular to the application of oridonin in the preparation of drugs for treating hyperuricemia and anti-gout. Background technique [0002] Uric acid, namely 2,6,8-purine trioxide, is the end product of human purine metabolism. Uric acid in the blood is produced by the oxidation of xanthine and hypoxanthine catalyzed by xanthine oxidase from buttermilk (XOD), and plays an important physiological role in protecting nerve cells and maintaining blood pressure. Under a normal purine diet, if the blood uric acid level on an empty stomach is higher than 420 μmol / L for men and 360 μmol / L for women on two different days, it is called hyperuricemia (hypeiuricemia, HUA). Internal deposition, causing histological changes, leading to gout, gouty arthritis, gouty nephropathy, etc. Hyperuricemia is often complicated by cardiovascular diseases, and is closely re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P19/06A61K36/53
CPCA61K31/352A61K36/53A61P19/06
Inventor 徐霞王馨迎崔伟琪可钰
Owner ZHENGZHOU UNIV
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