Application of oridonin in preparation of drugs for treating hyperuricemia and resisting gout
A technology for hyperuricemia and oridonin A is applied in pharmaceuticals, and the application field of oridonin A in the preparation of drugs for treating hyperuricemia and anti-gout can inhibit the activity of xanthine oxidase and achieve a remarkable effect. , Improve the effect of large side effects
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[0027] Effects of oridonin on hyperuricemia induced by yeast powder and potassium oxonate.
[0028] 40 healthy male Kunming mice, weighing 18-20 g, were provided by Animal Experiment Center of Henan Province. The mice were adaptively fed for one week in the SPF grade animal room of the School of Pharmacy, Zhengzhou University, Henan Province, and were divided into 4 groups using the random number table method, with 10 mice in each group, as follows:
[0029] 1. Normal control group;
[0030] 2. Model control group;
[0031] 3. Rubescensine A group;
[0032] 4. Positive control drug group.
[0033] After the adaptation period was over, the drug was given by gavage twice a day in the morning. First, the model control group, Rubescensin A group, and positive control group were given intragastric administration of yeast powder (30g / kg), and the normal control group was given the same amount of normal saline for intragastric administration; 1h later, the Oridonin A group was gi...
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