Application of rehmannia extract in preparation of medicine for preventing or treating hyperuricemia

A technology of hyperuricemia and rehmannia, applied in the preparation of drugs for the prevention or treatment of hyperuricemia, in the field of rehmannia extract, achieving remarkable effects, inhibiting xanthine oxidase activity, and reducing serum uric acid and creatinine levels

Pending Publication Date: 2022-02-01
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, catalpol, leonurin, rehmangusin D, and phenylethyl alcohol-like verbascoside of iridoid glycosides are the important functional components. Currently, rehmannia extract is used as a medicinal component to prevent and / or treat hyperuricemia and gout Not yet reported

Method used

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  • Application of rehmannia extract in preparation of medicine for preventing or treating hyperuricemia
  • Application of rehmannia extract in preparation of medicine for preventing or treating hyperuricemia
  • Application of rehmannia extract in preparation of medicine for preventing or treating hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Application of a kind of Rehmannia glutinosa in the preparation of drugs for the prevention or treatment of hyperuricemia

[0020] 1. Medicines and animal sources: 1# Rehmannia extract (containing 45% catalpol, 15% verbascoside, 8% leonurin, and 10% rehmannoside D), 2# rehmannia extract (containing 55% catalpol, 10% verbascoside %, Leonurin 9%, Rehmangusin D8%), 3# Rehmannia glutinosa (containing 35% catalpol, verbascoside 13%, 6% Leonurin, D12%) were purchased from Henan Zhongke Huaiyao Research Institute Co., Ltd. company; febuxostat was purchased from market pharmacies, 80mg / grain or tablet; potassium oxonate was purchased from Shanghai Bioengineering Co., Ltd., with a purity of ≥97.5%; yeast powder was purchased from Shanghai Bioengineering Co., Ltd.; xanthine oxidase (XOD ) activity detection kit (micro method) was purchased from Shanghai Bioengineering Co., Ltd.; healthy male SD rats aged 6-8 weeks, weighing 200±20g, were provided by the Animal Experime...

Embodiment 2

[0061] Example 2: Application of a Rehmannia glutinosa in the preparation of drugs for the prevention or treatment of hyperuricemia

[0062] Application of rehmannia extract in the preparation of drugs for preventing or treating hyperuricemia, or drugs for acute gout, chronic gout, gouty arthritis, gout attacks, uric acid nephrolithiasis or gouty nephropathy caused by hyperuricemia Or application in health products.

[0063] The rehmannia extract contains 45% of catalpol, 15% of verbascoside, 8% of motherwort and 10% of rehmangusin D in terms of mass percentage.

[0064] A medicine for preventing or treating hyperuricemia, which is prepared by conventional methods into powder, granule, tablet, capsule, pill, sachet or oral liquid by taking rehmannia extract, adding or not adding pharmaceutical excipients.

[0065] A health product for preventing or treating hyperuricemia, which is prepared by taking rehmannia extract, adding or not adding auxiliary materials, and preparing a ...

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Abstract

The invention relates to an application of a rehmannia extract in preparation of a medicine for preventing or treating hyperuricemia. The invention provides the new application of the rehmannia extract in preparation of the medicine for preventing or treating hyperuricemia. In hyperuricemia rats molded by combination of oteracil potassium and yeast, the rehmannia extract is administrated through intragastric administration according to three dosage groups of 50 mg/kg, 100 mg/kg and 200 mg/kg, after administration, the levels of serum uric acid and creatinine can be remarkably reduced, the activity of xanthine oxidase in liver tissues is inhibited, the effect of reducing the concentration of uric acid is generated, and the rehmannia extract has no obvious toxicity to the liver and the kidney. A new field is developed for the application of traditional Chinese medicinal materials, and a new direction is provided for the research and development of high-efficiency and low-toxicity uric acid-reducing and anti-gout medicines or the development of health-care foods.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine chemistry, and relates to the application of rehmannia extractum in the preparation of medicines for preventing or treating hyperuricemia. Background technique [0002] Uric acid is the terminal metabolite of human purine compounds. Purine metabolic disorders lead to hyperuricemia, such as excessive uric acid production and / or decreased renal and intestinal excretion leading to an excessive increase in serum uric acid concentration. According to the "Chinese Guidelines for the Diagnosis and Treatment of Hyperuricemia and Gout (2019)", hyperuricemia (HUA) refers to the concentration of serum uric acid (uric acid) on an empty stomach twice on a different day under a normal purine diet, regardless of gender. More than 420μmol / L. Hyperuricemia has become one of the serious public health problems in my country. Statistics in 2017 show that the prevalence of hyperuricemia in my cou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P19/06A61P13/04A61P13/12A61K31/7048A61K31/7032A23L33/105C12G3/055A61K125/00
CPCA61K36/804A61P19/06A61P13/04A61P13/12A61K31/7048A61K31/7032A23L33/105C12G3/055A23V2002/00A23V2200/30
Inventor 赵根海宋晓龙李永亮郑之明王鹏王晗王丽
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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