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A kind of ginkgo protein source ACE inhibitory peptide composition and its preparation method and application

A technology of ginkgo protein and inhibitory peptide, applied in the field of food and medicine, can solve problems such as products with no commercial development of blood pressure lowering effect, and achieve the effect of high safety

Active Publication Date: 2021-10-15
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on ACE inhibitory peptides derived from ginkgo protein is still in its infancy. At present, there are few research reports, and it only stays in simple hydrolysis conditions to explore, and there is no commercial development of products with hypotensive effect.

Method used

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  • A kind of ginkgo protein source ACE inhibitory peptide composition and its preparation method and application
  • A kind of ginkgo protein source ACE inhibitory peptide composition and its preparation method and application
  • A kind of ginkgo protein source ACE inhibitory peptide composition and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0053] The preparation of embodiment 1 ginkgo protein source ACE inhibitory peptide composition

[0054] One, the preparation of defatted ginkgo ginkgo powder

[0055] After the ginkgo is shelled and the membranous endocarp is removed, the ginkgo is placed in a freeze dryer and freeze-dried for 24-48 hours, the dried ginkgo is ground in a high-speed pulverizer, and the ginkgo powder is obtained after sieving.

[0056] Ginkgo powder and petroleum ether are fully mixed at a ratio of 1:12 (mass and volume), placed at 0-4°C, stirred once every 1-2h, and petroleum ether is replaced after 4-6h. After repeating 3-4 times, Until the ginkgo powder is white, then the ginkgo powder and petroleum ether are separated to collect the wet ginkgo powder. Finally, in a ventilation system, under normal temperature conditions, until the petroleum ether is completely volatilized, the defatted ginkgo powder is prepared.

[0057] Two, the preparation of ginkgo protein

[0058] Dissolve defatted g...

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Abstract

The invention discloses a ginkgo protein source ACE inhibitory peptide composition and its preparation method and application, belonging to the technical field of food and medicine; the main amino acid sequence of the ginkgo protein source ACE inhibitory peptide composition is GFDGR, NDPGR, LDQTYRP, REHETIIL , LRMPGPPSSDDY and LRMPGPPSDDYER are composed of six small molecular peptides. The specific preparation process includes: preparation of ginkgo protein, hydrolysis of ginkgo protein, enzymatic hydrolysis of ginkgo protein to obtain ACE inhibitory peptide crude product and separation and purification of ginkgo protein source ACE inhibitory peptide composition. The present invention utilizes biological enzyme technology to produce ginkgo protein source ACE inhibitory peptide composition, takes ACE inhibitory activity as the detection index, establishes the process and process parameters of biological enzyme technology to produce ginkgo protein ACE inhibitory peptide composition, and provides theoretical basis and technical support for industrial production Technical Support.

Description

technical field [0001] The invention relates to the technical field of food and medicine, in particular to a ginkgo protein source ACE inhibitory peptide composition and its preparation method and application. Background technique [0002] Hypertension is a chronic disease that is extremely harmful to human health. It is the main controllable risk factor for cardiovascular and cerebrovascular diseases such as coronary heart disease and stroke. The research results show that a 5mmHg reduction in blood pressure is equivalent to a 16% reduction in the risk of cardiovascular and cerebrovascular diseases. Currently, the first-line drugs used to treat hypertension mainly include: diuretics, receptor blockers, angiotensin-converting enzyme inhibitors, Calcium channel blockers, receptor blockers, angiotensin receptor antagonists and other six categories. Hundreds of billions of dollars are spent on antihypertensive drugs worldwide every year. At the same time, various side effects...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06C07K7/08C12P21/06C12P21/02C07K1/34C07K1/20C07K1/16C07K1/36G01N33/68A61K38/10A61P9/12A61K38/08
CPCC07K7/06C07K7/08C12P21/06C12P21/02G01N33/6848A61K38/10A61K38/08A61P9/12A61K2300/00A61K38/00C07K14/415A61K38/168
Inventor 侯俊财姜瞻梅钱珊珊高懿彤李金哲
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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