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Separable nanosheet and production method therefor

A manufacturing method and separation technology, applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as difficult reformation or modification, complex synthesis process and film formation process, sheet adhesion or aggregation, etc.

Pending Publication Date: 2021-03-09
THE UNIV OF TOKYO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Nanosheets using the above-mentioned organic molecules can be expected to be applied to medicines and biomaterials, but the problem is that their synthesis process and film-forming process are complicated, resulting in huge costs
[0007] Nanosheets are difficult to exist stably in the nano state, and thus have problems with the sheets sticking to each other or agglomerating, and also have the problem of being difficult to reform or modify their surface to prevent sticking or agglomerating

Method used

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  • Separable nanosheet and production method therefor
  • Separable nanosheet and production method therefor
  • Separable nanosheet and production method therefor

Examples

Experimental program
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Embodiment

[0224] Now, the present invention is described in more detail by way of examples, but the present invention is by no means limited to the following examples.

Synthetic example 1

[0225] [Synthesis Example 1: Synthesis of α,ω-dicarboxylated polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol]

[0226] α,ω-Dihydroxypolyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (Pluronic (trade mark) F68; PEO 76 PPOs 29 PEOs 76 ,M w =8,400g / mol; 2.50g, 0.30mmol), 2,2,6,6-tetramethylpiperidine 1-oxyl group (TEMPO; 203mg, 1.30mmol) and sodium bromide NaBr (202mg, 1.96mmol) in 28 mL of water. Thereafter, while stirring the solution, a 5 wt % sodium hypochlorite aqueous solution was slowly added dropwise until the pH value stopped changing. The resulting aqueous solution was stirred at room temperature for an additional 10 minutes. After that, 2.5 mL of ethanol was put into the solution to quench the reaction. Then, a 6M aqueous hydrochloric acid solution was put into the solution until the pH reached 2, and the target product was extracted with 40 mL of dichloromethane. Then, the obtained methylene chloride solution was ...

Synthetic example 2

[0227] [Synthesis Example 2: Synthesis of α,ω-bisaminopolyethylene glycol-block-polypropylene glycol-block-polyethylene glycol]

[0228] Preparation of α,ω-dihydroxypolyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (Pluronic (trademark) F68; PEO 76 PPOs 29 PEOs 76 ,M w =8,400 g / mol; 1 g, 0.119 mmol) in 10 mL of tetrahydrofuran, and was added dropwise to a solution of 0.212 g (1.31 mmol) of 1,1′-carbonyldiimidazole in 6.3 mL of tetrahydrofuran obtained separately. The resulting solution was further stirred overnight at room temperature, and then added dropwise to ethylenediamine (794 μL, 11.9 mmol). After the reaction was completed, tetrahydrofuran was evaporated, the resulting white solid was dissolved in water, and then purified by dialysis. After purification, water was removed by lyophilization to obtain the target product (0.92 g, 92%).

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Abstract

The present invention provides a separable nanosheet which comprises a plurality of pseudo-polyrotaxane structures and in which the structures are not adherent to each other and are easy to separate.The separable nanosheet of the present invention comprises a plurality of pseudo-polyrotaxane structures each comprising first cyclic molecules and a linear molecule piercing the cavities thereof to form a clathrate, wherein the linear molecules include, as part thereof, first linear molecules having an ionizing group which ionizes in water or an aqueous solution.

Description

technical field [0001] The present invention relates to isolated nanosheets comprising pseudopolyrotaxanes and / or polyrotaxanes. In particular, the present invention relates to isolated nanosheets comprising pseudopolyrotaxanes and / or polyrotaxanes, wherein the linear molecules forming the pseudopolyrotaxanes and / or polyrotaxanes comprise as part thereof a first linear molecule, The first linear molecules each have an ionizable group that ionizes in water or an aqueous solution. The invention also relates to materials comprising isolated nanoplatelets. The present invention also relates to methods for the manufacture of isolated nanosheets. Background technique [0002] In recent years, progress has been made in developing nanosheets having a thickness of 100 nm or less to applications such as drugs, catalysts, optical materials, electrodes, and biomaterials. As materials used therein, titanium oxide, boron nitride, carbon nitride, graphene, and the like have hitherto bee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/32A61K47/12A61K47/18A61K47/40B82Y5/00B82Y40/00
CPCC08G65/32B82Y40/00C08G65/331C08G2650/28A61K9/7007A61K47/6949A61K47/551A61K47/6935B82Y30/00C08G83/007C08G83/008C08B37/0015C08L5/16C08L71/02A61K47/6951A61K31/137A61K31/192A61K31/4704A61K31/5415A61K31/573A61K47/34A61K47/40
Inventor 伊藤耕三前田利菜上沼骏太郎
Owner THE UNIV OF TOKYO