Preparation technology and application of preparation for rhegmatogenous retinal detachment repositioning

A technique for retinal detachment and repositioning, which is applied in the preparation of rhegmatogenous retinal detachment preparations, can solve the problems of patients with poor visual quality, achieve the effects of promoting retinal reattachment, improving the cure rate, and reducing the difficulty of surgery

Active Publication Date: 2022-03-08
伊莱博生物科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the deepening of the understanding of the disease and the development of surgical equipment in recent years, the rate of retinal reattachment after one surgery for rhegmatogenous retinal detachment is gradually increasing. Although both surgical methods have good surgical success rates, the postoperative visual poor quality

Method used

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  • Preparation technology and application of preparation for rhegmatogenous retinal detachment repositioning
  • Preparation technology and application of preparation for rhegmatogenous retinal detachment repositioning
  • Preparation technology and application of preparation for rhegmatogenous retinal detachment repositioning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation process of rhegmatogenous retinal detachment preparation, comprising:

[0053] Step 1), adding 92% ethanol solution to the Poria cocos powder according to the solid-to-liquid ratio of 1g:10mL, reflux extraction 3 times, 3 hours each time, suction filtration, combined filtrates, concentrated, dried to obtain Poria cocos extract;

[0054] Step 2), according to the solid-liquid ratio of 1g: 10mL, add 90% ethanol solution to the Scutellaria barbata powder, reflux extraction 3 times, every 3h, filter with suction, combine the filtrate, concentrate, separate by polyamide column chromatography, water, 20% ethanol solution, 70% ethanol solution for elution, 70% ethanol solution eluate was concentrated and dried to obtain Scutellaria barbata extract;

[0055] In step 3), the Poria cocos extract and Scutellaria barbata extract are mixed in a weight ratio of 1:0.4 to obtain a rhegmatogenous retinal detachment preparation.

Embodiment 2

[0057] The preparation process of rhegmatogenous retinal detachment preparation, comprising:

[0058] Step 1), adding 98% ethanol solution to the Poria cocos powder according to the solid-to-liquid ratio of 1g:4mL, reflux extraction 4 times, each time for 2h, suction filtration, combined filtrates, concentration, and drying to obtain the Poria cocos extract;

[0059] Step 2), according to the solid-liquid ratio of 1g: 15mL, add 75% ethanol solution to the Scutellaria barbata powder, reflux extraction 4 times, each time for 2h, suction filtration, combine the filtrates, concentrate, separate by polyamide column chromatography, and use water successively , 20% ethanol solution, 70% ethanol solution eluting, 70% ethanol solution eluate is concentrated, dried, obtains Scutellaria barbata extract;

[0060] In step 3), the Poria cocos extract and Scutellaria barbata extract are mixed in a weight ratio of 1:0.4 to obtain a rhegmatogenous retinal detachment preparation.

Embodiment 3

[0062] The preparation process of rhegmatogenous retinal detachment preparation, comprising:

[0063] Step 1), add 95% ethanol solution to the Poria cocos powder according to the solid-liquid ratio of 1g:6mL, reflux extraction for 2.5h, filter, repeat the extraction of the filter residue twice, filter with suction, combine the filtrates, concentrate, and dry to obtain the Poria cocos extract;

[0064] Step 2), according to the solid-liquid ratio of 1g: 12mL, add 80% ethanol solution to the Scutellaria barbata powder, reflux extraction 4 times, each time for 1h, suction filtration, combine the filtrates, concentrate, separate by polyamide column chromatography, and use water successively , 20% ethanol solution, 70% ethanol solution eluting, 70% ethanol solution eluate is concentrated, dried, obtains Scutellaria barbata extract;

[0065] In step 3), the Poria cocos extract and Scutellaria barbata extract are mixed in a weight ratio of 1:0.4 to obtain a rhegmatogenous retinal det...

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Abstract

The invention provides a preparation process for rhegmatogenous retinal detachment preparations, belonging to the technical field of retinal diseases, including: step 1), using ethanol solution to extract Poria cocos powder to obtain Poria cocos extract; step 2), using ethanol solution to extract Scutellaria barbata powder to obtain semi lotus extract; and step 3), mixing the extract of Poria cocos and the extract of Scutellaria barbata to obtain rhegmatogenous retinal detachment preparation. Wherein, the Poria cocos extract contains at least 80 wt% of triterpenoids, and the barbatae extract contains at least 60 wt% of flavonoids; the weight ratio of the Poria cocos extract and the barbatae extract is 1:0.2-0.7. The preparation obtained by the preparation process of the invention can reduce the difficulty of retinal detachment repositioning and promote the recovery of visual function after retinal detachment repositioning.

Description

technical field [0001] The invention belongs to the technical field of retinal diseases, and in particular relates to a preparation process for rhegmatogenous retinal detachment preparations. Background technique [0002] Retinal detachment (RD) refers to the separation of retinal neuroepithelium and retinal pigment epithelium, including three types of rhegmatogenous, hyperplastic and exudative. It is a common and frequently-occurring disease in ophthalmology. If the disease is delayed or treated improperly , is also one of the common blinding fundus diseases. Rhegmatogenous Retinal Detachment (RRD) is the most common type of retinal detachment. The basic principle of occurrence is the formation of retinal tears after retinal degeneration or degenerative changes. The neuroepithelium is separated from the pigment epithelium. Clinically, RRD is the most common type of retinal detachment. Its onset is sudden and its development is fast. Once it occurs, the visual acuity of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61P27/02A61K36/481A61K36/076
CPCA61K36/076A61K36/539A61K36/481A61P27/02A61K2236/333A61K2236/39A61K2300/00
Inventor 罗莎莎武志峰杨璐菲
Owner 伊莱博生物科技(上海)有限公司
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